Tight Junctions
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Tight Junctions
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Author : Marcelino Cereijido
language : en
Publisher: CRC Press
Release Date : 2001-06-26
Tight Junctions written by Marcelino Cereijido and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-06-26 with Medical categories.
As the first detailed overview of the subject, Tight Junctions brought together diverse perspectives from leading investigators to provide a multidisciplinary overview of the field. Since its publication in 1992, there has been an explosion of information about tight junctions, particularly in the area of molecular structure, cell and molecular bio
Tight Junctions In Inflammation And Cancer
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Author : Ajaz A. Bhat
language : en
Publisher: Springer Nature
Release Date : 2023-10-12
Tight Junctions In Inflammation And Cancer written by Ajaz A. Bhat and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-12 with Science categories.
This book provides an updated account of tight junctions of different epithelia and endothelia and addresses their anatomy, biochemistry, physiology, synthesis, assembly, and modulation. It also discusses the relationship between molecular structure, function, regulation, posttranslational modifications of tight junction proteins and their role in gut microbiota maintenance, epithelial-mesenchymal transition, and intestinal barrier dysfunction-associated disorders important for the progression of human cancers. This book presents the pathological alterations of tight junctions at the blood-brain barrier that intensify or even initiate neurological dysfunction. Further, it reviews the significance of tight junctions and tight junction proteins in cancer development, infectious diseases, allergic reactions, and autoimmune disorders. Lastly, it highlights strategies for modulating tight junctions to enhance drug availability and organ deposition. This book is immensely useful for basic, translational, clinical, and interdisciplinary cancer researchers, practicing oncologists, and immunologists.
Tight Junctions
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Author : Lorenza González-Mariscal
language : en
Publisher: Springer Nature
Release Date : 2022-05-31
Tight Junctions written by Lorenza González-Mariscal and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-31 with Science categories.
This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.
Molecular Structure And Function Of The Tight Junction
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Author : Michael Fromm
language : en
Publisher: John Wiley & Sons
Release Date : 2009-06-22
Molecular Structure And Function Of The Tight Junction written by Michael Fromm and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-22 with Medical categories.
Aim of this volume is to clarify the relationship between molecular structure and function of tight junction proteins, as well as their regulation and their role in diseases. Current research may form a basis for future diagnostic and therapeutic approaches to diseases which seem to have not much in common but are characterized by defects of organ barriers, like Crohn's disease, renal hypertension, inner ear deafness, and cancerous diseases. Topics include the functions of distinct tight junction proteins as barrier or channel formers for solutes and water, characteristics of the tight junction in inflammatory bowel diseases, posttranslational modifications of tight junction proteins, the relation between renal tight junction proteins and blood pressure control, and the molecular structure of claudin-claudin interactions NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Tight Junctions
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Author : Marcelino Cereijido
language : en
Publisher: CRC Press
Release Date : 2001-06-26
Tight Junctions written by Marcelino Cereijido and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-06-26 with Medical categories.
As the first detailed overview of the subject, Tight Junctions brought together diverse perspectives from leading investigators to provide a multidisciplinary overview of the field. Since its publication in 1992, there has been an explosion of information about tight junctions, particularly in the area of molecular structure, cell and molecular bio
Adherens Junctions From Molecular Mechanisms To Tissue Development And Disease
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Author : Tony Harris
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-07
Adherens Junctions From Molecular Mechanisms To Tissue Development And Disease written by Tony Harris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-07 with Medical categories.
Cell–cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology. • How did AJs evolve? • How do cadherins and catenins interact to assemble AJs and mediate adhesion? • How do AJs interface with other cellular machinery to couple adhesion with the whole cell? • How do AJs affect cell behaviour and multicellular development? • How can abnormal AJ activity lead to disease?
The Tight Junction And Its Proteins More Than Just A Barrier
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Author : Michael Fromm
language : en
Publisher: MDPI
Release Date : 2020-11-20
The Tight Junction And Its Proteins More Than Just A Barrier written by Michael Fromm and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-20 with Science categories.
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
Tight Junctions In Cancer Metastasis
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Author : Tracey A. Martin
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-02-26
Tight Junctions In Cancer Metastasis written by Tracey A. Martin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-26 with Medical categories.
There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.
A Laboratory Guide To The Tight Junction
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Author : Jianghui Hou
language : en
Publisher: Academic Press
Release Date : 2020-04-24
A Laboratory Guide To The Tight Junction written by Jianghui Hou and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-24 with Science categories.
A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases. - Provides consistent and detailed research methods - Covers various cell, tissue and animal models - Includes step-by-step guidance from beginner to sophisticated levels
Intraocular Drug Delivery
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Author : Glenn J. Jaffe
language : en
Publisher: CRC Press
Release Date : 2006-03-13
Intraocular Drug Delivery written by Glenn J. Jaffe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-13 with Medical categories.
This reference studies the most recent advances in the development of ocular drug delivery systems. Covering methods to treat or prevent ocular inflammation, retinal vascular disease, retinal degeneration, and proliferative eye disease, this source covers breakthroughs in the management of endophthalmitis, uveitis, diabetic macular edema, and age-r