Calcitonin Gene Related Peptide Cgrp Novel Biology And Treatments

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Calcitonin Gene Related Peptide Cgrp Novel Biology And Treatments

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Author : Susan D. Brain
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-17

Calcitonin Gene Related Peptide Cgrp Novel Biology And Treatments written by Susan D. Brain and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-17 with Science categories.

The Calcitonin Gene Related Peptide Family

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Author : Deborah L. Hay
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-03

The Calcitonin Gene Related Peptide Family written by Deborah L. Hay and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-03 with Medical categories.

In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

Calcitonin Gene Related Peptide Cgrp Mechanisms

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Author : Susan D. Brain
language : en
Publisher: Springer Nature
Release Date : 2019-08-31

Calcitonin Gene Related Peptide Cgrp Mechanisms written by Susan D. Brain and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-31 with Medical categories.

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.

The Calcitonin Gene Related Peptide Family

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Author : Deborah L. Hay
language : en
Publisher: Springer
Release Date : 2009-10-14

The Calcitonin Gene Related Peptide Family written by Deborah L. Hay and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-14 with Medical categories.

In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

The Cgrp Family

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Author : David Poyner
language : en
Publisher: CRC Press
Release Date : 2019-12-02

The Cgrp Family written by David Poyner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-02 with categories.

This book is based on presentations given at CGRP '98, the Third International Meeting on CGRP and related peptides held in the UK in May 1998. The principal speakers have each contributed a chapter and many of the short and poster communications will also be found here. This book follows from the tradition set by the First and Second Meetings in 1992 and 1995 when the proceedings were published. The work is aimed at the specialist in the field, but it is hoped that many of the chapters will also prove useful as introductions to those wishing to gain greater familiarity with the biology and pharmacology of these important peptides. The book begins with a broad overview of the field, past and present. It is followed by two chapters dealing with the "classical" pharmacology of CGRP. In particular there is an account of the pitfalls of the present generation of CGRP antagonists and the dangers of assuming that every action of CGRP is mediated by a CGRP receptor. However the bulk of this section is taken up by the recent developments concerning the cloning of receptors for CGRP and adrenomedullin. An exciting story is emerging of how a single molecule, calcitonin receptor-like receptor (CRLR), can mediate the response to both CGRP and adrenomedullin depending on the presence of different members of a family of accessory proteins, the Receptor Activity Modifying Proteins (RAMPs). This is covered in three chapters and is followed by an account of another accessory protein associated with CGRP responsiveness, Receptor Component Protein (RCP). Following sections of the book deal with the biochemistry, physiology and pharmacology of receptors for the allied peptides amylin and adrenomedullin. The close connections between amylin and calcitonin receptors are highlighted and role of amylin in the regulation of food intake is then considered. The molecular nature of adrenomedullin receptors is addressed in an earlier chapter but in this section their pharmacology is examined. T

The Calcitonin Gene Related Peptide Family

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Author : Deborah L. Hay
language : en
Publisher:
Release Date : 2009-10-04

The Calcitonin Gene Related Peptide Family written by Deborah L. Hay and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-04 with MEDICAL categories.

The Cgrp Family

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Author : David Poyner
language : en
Publisher: CRC Press
Release Date : 2000

The Cgrp Family written by David Poyner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.

This book presents a broad overview of Calcitonin, Gene-Related Peptide (CGRP) and the related peptides amylin and adrenomedullin. It deals with the biochemistry, physiology, and pharmacology of receptors for the allied peptides amylin and adrenomedullin.

The M2 Macrophage

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Author : Tamás Röszer
language : en
Publisher: Springer Nature
Release Date : 2020-08-03

The M2 Macrophage written by Tamás Röszer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-03 with Medical categories.

Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.

Peptidomics

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Author : Mikhail Soloviev
language : en
Publisher: John Wiley & Sons
Release Date : 2007-12-21

Peptidomics written by Mikhail Soloviev and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-21 with Science categories.

The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.

Neurobiological Basis Of Migraine

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Author : Turgay Dalkara
language : en
Publisher: John Wiley & Sons
Release Date : 2017-08-07

Neurobiological Basis Of Migraine written by Turgay Dalkara and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-07 with Medical categories.

Published with the New York Academy of Sciences A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the world. Written for researchers and clinicians alike, the book features edited contributions from distinguished experts in the field, taking a focused, yet wide-ranging approach to the subject. It begins by exploring the pathways and networks mediating migraine headaches, their underlying physiological mechanisms, characteristics of visceral pain, and the concept of dural neurogenic inflammation. From there the authors delve into the mechanisms sustaining the head pain and photophobia associated with migraines, and they review the pharmacology of newly discovered migraine treatments. These basic chapters are followed by clinical and genetic studies linking to key issues, including cortical spreading depression, ion channels, transporters, and epilepsy. Reviews of the latest advances in our understanding of the neurobiological basis of migraine Translates important research findings from around the globe into novel treatments strategies currently being investigated Provides researchers and clinicians with a deep understanding of the primary mechanisms of migraine from migraine modeling to clinical applications Includes contributions by many of the most respected researchers in the field, world-wide Discusses exciting recent developments in migraine mutations and their role in CSD, as well as the role of CSD in aura and trigeminal activation Timely, comprehensive, and authoritative, Neurobiological Basis of Migraine is an indispensable working resource for clinicians and migraine, headache, and pain researchers, including neurobiologists, neuropharmacologists, neurologists, and vascular neurobiologists, as well as graduate students in those fields who are involved in researching migraine headaches.