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Candida Biofilms


Candida Biofilms
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Candida Biofilms


Candida Biofilms
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Author : Juliana Campos Junqueira
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-03

Candida Biofilms written by Juliana Campos Junqueira and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-03 with Science categories.




Microbial Biofilms


Microbial Biofilms
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Author : Chaminda Jayampath Seneviratne
language : en
Publisher: CRC Press
Release Date : 2017-07-12

Microbial Biofilms written by Chaminda Jayampath Seneviratne and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-12 with Medical categories.


Microbial Biofilms: Omics Biology, Antimicrobials and Clinical Implications is a comprehensive survey of microbial biofilms and their role in human health and disease with contributions from world renowned experts in molecular microbiology, proteomics, genomics, metabolomics and infectious diseases. The book is intended to serve as a guide for students, as well as a reference for researchers, clinicians and industry professionals. The chapters cover bacterial and fungal microbiomes, and the latest omics techniques organized in a clear and up-to-date manner. One of the highlights of this book is the comprehensive information on "omics of microbial biofilms". The chapters dedicated to metagenomics, proteomics and metabolomics are designed to provide a simple and holistic review of the current knowledge and, the applications of these techniques in the field of microbial biofilms. In addition to introductory chapters on microbial biofilms and their clinical implications, subsequent chapters delve into oral biofilms, their composition, and metagenomic diversity. Thereafter, mechanisms of drug resistance in microbial biofilms are reviewed, as well as the proteomic and metabolomic characterization of this resistance. The book includes a comprehensive discussion of persister cells and host–microbial interactions on mucosal surfaces. Finally, the book concludes with a summary of novel therapeutic approaches for biofilms such as synbiotics and biogenics.



Fungal Biofilms And Related Infections


Fungal Biofilms And Related Infections
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Author : Christine Imbert
language : en
Publisher: Springer
Release Date : 2016-08-09

Fungal Biofilms And Related Infections written by Christine Imbert and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-09 with Science categories.


This book covers the latest data available to understand the mechanisms causing the formation of single species fungal biofilms or polymicrobial biofilms involving fungal species; specific chapters present hot topics such as resistance mechanisms and composition and role of the matrix. Moreover, it reviews updated data on biofilms that contain yeasts or filamentous fungi and develop in the human body or in water and may cause infections. The latest available data for both diagnostic and treatment of infections associated to fungi growing in biofilms is also presented. The activity of antifungal and disinfectant agents against fungal biofilms is discussed in specific chapters and future treatments on natural sources are suggested. This book bridges the gap between basic and applied research. It is the result of many years of research work done by laboratories worldwide, all known for their expertise on fungal biofilms.



Candida Albicans Cellular And Molecular Biology


Candida Albicans Cellular And Molecular Biology
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Author : Rajendra Prasad
language : en
Publisher: Springer
Release Date : 2017-01-31

Candida Albicans Cellular And Molecular Biology written by Rajendra Prasad and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-31 with Science categories.


This book on Candida albicans and similar pathogens provides a timely overview of the groundbreaking discoveries made in the areas of drug resistance, host–pathogen interactions, virulence, host immune system modulation, etc., in the last two decades. This comprehensive 2nd Edition includes chapters on fungal infections, hyphal morphogenesis, molecular mechanisms of antifungal resistance, antifungal agents, multidrug transporters, virulence mechanisms in Candida albicans, host–pathogen interactions, the cell wall, fungal biofilms, lipids and antifungal resistance, signaling mechanisms and last but not the least host-immune responses. As such, it offers an ideal reference guide for mycologists, researchers, pharmacists, clinicians, and undergraduate students engaged or interested in fungal research. It will also benefit clinicians, who are required to keep abreast of the current state of research on antifungal drug resistance and antifungal development.



Microbial Biofilms


Microbial Biofilms
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Author : Mahmoud Ghannoum
language : en
Publisher: John Wiley & Sons
Release Date : 2020-08-11

Microbial Biofilms written by Mahmoud Ghannoum and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-11 with Science categories.


An examination of the research and translational application to prevent and treat biofilm-associated diseases In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense. Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically, Microbial Biofilms provides state-of-the-art research in the field of bacterial and fungal biofilms detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms future areas of research and their translational and clinical applications Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.



Biofilm Control And Antimicrobial Agents


Biofilm Control And Antimicrobial Agents
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Author : S. M. Abu Sayen
language : en
Publisher: CRC Press
Release Date : 2014-02-24

Biofilm Control And Antimicrobial Agents written by S. M. Abu Sayen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-24 with Science categories.


This title includes a number of Open Access chapters. This new book highlights some of the exciting research that has recently been done in the important and far-ranging field of biofilms and microbial agents. It discusses antimicrobial agents in relation to biofilm control and resistance. The book also introduces biofilm formation and mitigation strategies. It helps explores long-term solutions to the challenges imposed by biofilms.



Characterizing The Inhibition Of Neutrophil Extracellular Traps By Candida Albicans Biofilms


Characterizing The Inhibition Of Neutrophil Extracellular Traps By Candida Albicans Biofilms
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Author : John Franz Kernien
language : en
Publisher:
Release Date : 2020

Characterizing The Inhibition Of Neutrophil Extracellular Traps By Candida Albicans Biofilms written by John Franz Kernien and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.


Candida albicans is a frequent hospital-acquired fungal pathogen and cause of invasive candidiasis. When grown on surfaces like implanted medical devices as a biofilm, Candida is surrounded by a protective extracellular matrix, and resistant to host defenses and antifungal drugs. Neutrophils are the primary responder to fungal infections, including candidiasis. One host defense resisted by Candida biofilms are neutrophil extracellular traps (NETs). NETs consist of web-like nuclear DNA with antimicrobial proteins released to stimuli like large or aggregated pathogens. NET release entraps these pathogens, which are then killed and prevented from disseminating. The elongated hyphae and aggregated nature of C. albicans biofilm suggests NET release would be an effective way to combat this infection. However, previous work demonstrated that C. albicans biofilm inhibits NET release. Here, we examine components of C. albicans biofilm and neutrophils to determine their role in this inhibition of NET release. First, we determined that fungal morphology for biofilm formation does not play a role in inhibiting NET release to C. albicans biofilms. We grew C. albicans biofilms of clinical strains with vastly different filamentation, determining that despite differing morphologies and thickness, biofilms uniformly inhibited NET release. Next, we examined NET release phenotypes of neutrophils from patients with invasive candidiasis to confirm the clinical relevance of NET inhibition by C. albicans biofilm. We found that despite increased baseline and PMA-induced NET release relative to healthy neutrophils, these patient neutrophils released a similar amount of NETs to planktonic C. albicans, and that C. albicans biofilm still inhibited NET release. Finally, we looked at the role of prostaglandin E2 (PGE2) in inhibiting NET release to C. albicans biofilm, as it inhibits NET release to other stimuli. We found that PGE2 is highly present on the biofilm surface, and that PGE2 inhibitory receptor EP4 plays a role in the inhibition of NET release by C. albicans biofilm. Together, we demonstrate resilience of this inhibition to NET release by biofilms across a variety of morphologies, show the relevance of this phenotype for patients with invasive candidiasis, and illustrate the role of PGE2 as a component of this persistent inhibition.



Candida Species


Candida Species
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Author : Richard Calderone
language : en
Publisher: Springer Nature
Release Date : 2022-08-25

Candida Species written by Richard Calderone and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-25 with Science categories.


This updated volume explores Candida and candidiasis methods, useful to a wide variety of Candida scientists including those new to the field. Beginning with a section on the Candida genome, the book continues by covering techniques for antifungal discovery and studying resistance, pathogenesis and virulence, communities, as well as immunity. Biofilm protocols are also featured. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Candida Species: Methods and Protocols, Second Edition serves as an ideal guide for researchers working to further our understanding of this family of infective fungi.



Pathogenic Yeasts


Pathogenic Yeasts
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Author : Ruth Ashbee
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-27

Pathogenic Yeasts written by Ruth Ashbee and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-27 with Science categories.


Mycological studies of yeasts are entering a new phase, with the sequencing of multiple fungal genomes informing our understanding of their ability to cause disease and interact with the host. At the same time, the ongoing use of traditional methods in many clinical mycology laboratories continues to provide information for the diagnosis and treatment of patients. This volume reviews various aspects of pathogenic yeasts and what is known about their molecular and cellular biology and virulence, in addition to looking at clinical and laboratory findings. As each chapter is written by a leading expert in the field, this book summarizes in one volume much of the latest research on several pathogenic yeasts, including Candida, Cryptococcus, Malassezia and yeasts of emerging importance. The importance of laboratory diagnosis, antifungal susceptibility testing, antifungal resistance and yeast diseases in animals are reviewed.



Antifungal Drug Discovery New Theories And New Therapies


Antifungal Drug Discovery New Theories And New Therapies
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Author : Chaminda Jayampath Seneviratne
language : en
Publisher: Frontiers Media SA
Release Date : 2016-09-13

Antifungal Drug Discovery New Theories And New Therapies written by Chaminda Jayampath Seneviratne and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-13 with Microbiology categories.


Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.