Caveolae And Lipid Rafts Roles In Signal Transduction And The Pathogenesis Of Human Disease
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Caveolae And Lipid Rafts Roles In Signal Transduction And The Pathogenesis Of Human Disease
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Author : Edward Bittar
language : en
Publisher: Elsevier
Release Date : 2005-10-07
Caveolae And Lipid Rafts Roles In Signal Transduction And The Pathogenesis Of Human Disease written by Edward Bittar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-07 with Science categories.
Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.
Membrane Microdomain Signaling
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Author : Mark P. Mattson
language : en
Publisher: Springer Science & Business Media
Release Date : 2005
Membrane Microdomain Signaling written by Mark P. Mattson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
From intramolecular asymmetries to raft assemblies: a short guide for the puzzled in lipidomics / Ephraim Yavin and Annette Brand -- Regulatory aspects of membrane microdomain (raft) dynamics in live cells: a biophysical approach / János Matkó and János Szöllosi -- Lipid raft membrane skeletons / Elizabeth J. Luna ... [et al.] -- Role of cholesterol in membrane microdomain signaling / Christopher J. Fielding -- Raft lipid metabolism in relation to alkyl-lysophospholipid-induced apoptosis / Arnold H. van der Luit, Marcel Verheij, and Wim J. van Blitterswijk -- Role of lipid rafts in signal transduction and synaptic plasticity of neural cells / Markus Delling and Melitta Schachner -- Role of rafts in virus fusion and budding / Wu Ou and Jonathan Silver -- Alterations in raft lipid metabolism in aging and neurodegenerative disorders / Mark P. Mattson, Roy G. Cutler, and Norman J. Haughey -- Caveolin and cancer: a complex relationship / Mordechai Liscovitch ... [et al.] -- Dietary modulation of lipid rafts: implications for disease prevention and treatment / Mark P. Mattson.
Probes And Tags To Study Biomolecular Function
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Author : Lawrence W. Miller
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-02
Probes And Tags To Study Biomolecular Function written by Lawrence W. Miller and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-02 with Science categories.
The only resource to systematically review current experimental methods, this handy reference enables researchers to select the best solution for their experimental problems. For each method covered, the book provides step-by-step protocols, illustrated by typical research applications. After an initial section on probing the lipid bilayer, the text moves on to discuss probing proteins -- including membrane proteins -- and nucleic acids. The first single publication to incorporate chemical markers, fluorescent probes and genetic tags allows a well-informed comparison of different solutions for the same problem in molecular analytics.
Cholesterol Binding And Cholesterol Transport Proteins
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Author : J. Robin Harris
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Cholesterol Binding And Cholesterol Transport Proteins written by J. Robin Harris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Science categories.
Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders. It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL.
Lipid Rafts And Caveolae
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Author : Christopher J. Fielding
language : en
Publisher: John Wiley & Sons
Release Date : 2006-12-13
Lipid Rafts And Caveolae written by Christopher J. Fielding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Science categories.
This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail. Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include: Historical background Distinct structures and functions Structural basis Signaling Viral entry and virion budding Cholesterol transport Caveolins Lipid shells Cell polarity and intracellular trafficking Cancer cells Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.
Advances In Molecular And Cell Biology
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Author : Edward Bittar
language : en
Publisher: Elsevier Science
Release Date : 1992
Advances In Molecular And Cell Biology written by Edward Bittar and has been published by Elsevier Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Science categories.
The fourth volume of the Advances in Molecular and Cell Biology series. Cell biology is a rapidly-developing discipline, bringing together many separate biological sciences. The interrelations of cell structure and function at molecular and subcellular levels are the central theme of the series.
The First Outstanding 50 Years Of Universit Politecnica Delle Marche
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Author : Sauro Longhi
language : en
Publisher: Springer Nature
Release Date : 2020-01-02
The First Outstanding 50 Years Of Universit Politecnica Delle Marche written by Sauro Longhi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-02 with Science categories.
The book describes the significant multidisciplinary research findings at the Università Politecnica delle Marche and the expected future advances. It addresses some of the most dramatic challenges posed by today’s fast-growing, global society and the changes it has caused. It also discusses solutions to improve the wellbeing of human beings. The book covers the main research achievements in the various disciplines of the life sciences, and includes chapters that highlight mechanisms relevant to all aspects of human diseases, the molecular, cellular, and functional basis of therapy, and its translation into the management of people’s health needs. It also describes research on traditional and innovative foods to enhance quality, safety and functionality, and to develop bioactive/nutraceutical compounds. Further chapters address conservation and management of various environments, from the forests to the oceans, describing the studies on countermeasures against climate changes and terrestrial/aquatic pollutants, and on terrestrial/marine biodiversity, ecosystems and landscapes, erosion of genetic biodiversity, innovative aquaculture feed, sustainable crop production and management of forests. Lastly, the book reports the findings of research work on different classes of biomolecules, and on the molecular basis of antibiotic resistances and their diffusion.
Caveolins In Cancer Pathogenesis Prevention And Therapy
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Author : Isabelle Mercier
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-03
Caveolins In Cancer Pathogenesis Prevention And Therapy written by Isabelle Mercier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-03 with Medical categories.
Caveolins are important structural proteins of Caveolae, small invaginations of the membrane. They have been shown to play an important role in the pathogenesis of multiple cancers. In this volume, we will mainly focus on the importance of Caveolin-1 in breast, prostate, lung, skin, colon, pancreatic and brain cancers with also a mention of the novel role of Caveolin-3 in breast cancer.
Cerebral And Cerebellar Cortex
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Author : Stavros J. Baloyannis
language : en
Publisher:
Release Date : 2021
Cerebral And Cerebellar Cortex written by Stavros J. Baloyannis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Brain categories.
Cerebral and Cerebellar Cortex - Interaction and Dynamics in Health and Disease discusses several important issues of cerebro-cerebellar collaboration and interactions. The morphological and functional study of the cerebral and cerebellar cortices and their interaction has considerable value for interpreting the clinical phenomenology of cortical degenerations in the initial stage of the disease. In addition, the analysis of cerebro-cerebellar interactions strongly supports the concept of the close functional unity and harmonization of the brain and the cerebellum, underlining the important role that the cerebellar cortex plays in the performance of higher mental faculties, creativity, emotional processes, and homeostatic equilibrium of the human body.
Caveolins And Caveolae
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Author : Jean-François Jasmin
language : en
Publisher: Springer
Release Date : 2012-01-30
Caveolins And Caveolae written by Jean-François Jasmin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-30 with Medical categories.
Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.