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Lipid Rafts And Caveolae

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Lipid Rafts And Caveolae

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Author : Christopher J. Fielding
language : en
Publisher: John Wiley & Sons
Release Date : 2006-12-13

Lipid Rafts And Caveolae written by Christopher J. Fielding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Science categories.

This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail. Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include: Historical background Distinct structures and functions Structural basis Signaling Viral entry and virion budding Cholesterol transport Caveolins Lipid shells Cell polarity and intracellular trafficking Cancer cells Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.

Caveolae And Lipid Rafts Roles In Signal Transduction And The Pathogenesis Of Human Disease

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Author : Edward Bittar
language : en
Publisher: Elsevier
Release Date : 2005-10-07

Caveolae And Lipid Rafts Roles In Signal Transduction And The Pathogenesis Of Human Disease written by Edward Bittar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-07 with Science categories.

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

Membrane Microdomains In Disease Lipid Rafts

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Author : Jan Kliemann
language : de
Publisher: GRIN Verlag
Release Date : 2012

Membrane Microdomains In Disease Lipid Rafts written by Jan Kliemann and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.

Studienarbeit aus dem Jahr 2005 im Fachbereich Medizin - Anatomie, Physiologie, Cytologie, Note: 2, Charité - Universitätsmedizin Berlin (Institut für Pharmakologie), Sprache: Deutsch, Abstract: Seit der Formulierung der Theorie des "Flüssig-Mosaik-Modells" durch Singer und Nicolson, deren Grundlagen bis heute weiterhin Gültigkeit besitzt, sind inzwischen schon einige Jahre vergangen. Die Physiologie und Biochemie von biologischen Membranen ist seitdem zu einem äusserst wichtigen Thema in vielen Bereichen der Wissenschaft geworden. Neue Verfahren wurden entwickelt, neue Ansätze gefunden und alte Ansichten präzisiert oder gar geändert. Die vor ungefähr fünfzehn Jahren erstmals so genannten "Lipid rafts" (kurz: Rafts) sind ein solcher neuer Ansatz. Es handelt sich dabei um eine Form von Mikrodomänen, die durch eine bestimmte Zusammensetzung von Lipiden gekennzeichnet ist und deren Funktionen sich als äusserst vielfältig erwiesen haben. "Lipid rafts" sind beteiligt an der Endozytose, der Signaltransduktion, der Membranbiosynthese und der Pathogenese zahlreicher Krankheiten. Insbesondere aufgrund dieses letzten Punktes, haben sie auch in der medizinischen Forschung Aufsehen erregt. Ich werde diese Arbeit mit geschichtlichen Hintergründen, Definitionen und Abgrenzungen zu anderen ähnlichen Begriffen, und dem Aufbau von "Lipid rafts" beginnen. Es folgt eine Erläuterung von zwei ihrer Funktionen, nämlich der Endozytose und des Membranstoffwechsels.. Punkt vier enthält eine Diskussion über die Raft-abhängige Signaltransduktion, welche durch den Antikörper IgE an Mastzellen zur Ausschüttung von Histaminen führen kann. Als fünften Punkt setze ich mich stellvertretend anhand des HIV mit dem Problem auseinander, wie parasitäre Mikroorganismen "Lipid rafts" für ihre Zwecke nutzen. Abschließend folgt eine Zusammenfassung, in der ich auch verbleibende, mehr oder weniger ungeklärte Fragen zum Thema benennen möchte.

Membrane Dynamics And Domains

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Author : Peter J. Quinn
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Membrane Dynamics And Domains written by Peter J. Quinn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.

The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes is often extremely complex. Many hundreds of different molecular species of lipid can be identified in some membranes. Remarkably, the particular composition of each membrane appears to be main tained within relatively narrow limits and its identity distinguished from other morphologically-distinct membranes.

Membrane Microdomain Signaling

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Author : Mark P. Mattson
language : en
Publisher: Springer Science & Business Media
Release Date : 2005

Membrane Microdomain Signaling written by Mark P. Mattson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.

From intramolecular asymmetries to raft assemblies: a short guide for the puzzled in lipidomics / Ephraim Yavin and Annette Brand -- Regulatory aspects of membrane microdomain (raft) dynamics in live cells: a biophysical approach / János Matkó and János Szöllosi -- Lipid raft membrane skeletons / Elizabeth J. Luna ... [et al.] -- Role of cholesterol in membrane microdomain signaling / Christopher J. Fielding -- Raft lipid metabolism in relation to alkyl-lysophospholipid-induced apoptosis / Arnold H. van der Luit, Marcel Verheij, and Wim J. van Blitterswijk -- Role of lipid rafts in signal transduction and synaptic plasticity of neural cells / Markus Delling and Melitta Schachner -- Role of rafts in virus fusion and budding / Wu Ou and Jonathan Silver -- Alterations in raft lipid metabolism in aging and neurodegenerative disorders / Mark P. Mattson, Roy G. Cutler, and Norman J. Haughey -- Caveolin and cancer: a complex relationship / Mordechai Liscovitch ... [et al.] -- Dietary modulation of lipid rafts: implications for disease prevention and treatment / Mark P. Mattson.

Caveolins And Caveolae

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Author : Jean-François Jasmin
language : en
Publisher: Springer
Release Date : 2012-01-30

Caveolins And Caveolae written by Jean-François Jasmin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-30 with Medical categories.

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.

Caveolins And Caveolae

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Author : Jean-François Jasmin
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-12

Caveolins And Caveolae written by Jean-François Jasmin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-12 with Medical categories.

Intracellular Cholesterol Trafficking

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Author : T.Y. Chang
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Intracellular Cholesterol Trafficking written by T.Y. Chang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL TRAFFICKING This volume is an elaboration of an earlier small meeting held in St. Louis, Missouri. In April 1997, many of the authors met for a two-day meeting devoted entirely to intracellular cholesterol trafficking. The rationale for this meeting was that investigators interested in this topic worked in a variety of fields, and rarely, if ever, all met together. Everybody knew each other's papers but mostly worked in isolation from one another. Understanding of cholesterol trafficking also appeared to have reached the point where it would start to rapidly expand beyond these few laboratories. Understanding of cholesterol trafficking was moving from a largely descriptive science into the molecular age. It seemed a good time to get together and see how much we agreed upon up to this point. More authors contributed to this volume than attended the St. Louis meeting. That meeting was generously funded by grants from Bristol-Myers Squibb, Merck and Company and Parke-Davis, however, the total funding available limited the size of the meeting. For the book, we are not so limited and have tried to be as inclusive as possible and pretty much invited everyone who is presently active in this area. We were quite fortunate to successfully recruit the authors we sought for each of these chapters. The authors and their contributions can be organized by particular interests and particular areas of expertise.

Physics Of Biological Membranes

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Author : Patricia Bassereau
language : en
Publisher: Springer
Release Date : 2018-12-30

Physics Of Biological Membranes written by Patricia Bassereau and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-30 with Science categories.

This book mainly focuses on key aspects of biomembranes that have emerged over the past 15 years. It covers static and dynamic descriptions, as well as modeling for membrane organization and shape at the local and global (at the cell level) scale. It also discusses several new developments in non-equilibrium aspects that have not yet been covered elsewhere. Biological membranes are the seat of interactions between cells and the rest of the world, and internally, they are at the core of complex dynamic reorganizations and chemical reactions. Despite the long tradition of membrane research in biophysics, the physics of cell membranes as well as of biomimetic or synthetic membranes is a rapidly developing field. Though successful books have already been published on this topic over the past decades, none include the most recent advances. Additionally, in this domain, the traditional distinction between biological and physical approaches tends to blur. This book gathers the most recent advances in this area, and will benefit biologists and physicists alike.

Gm3 Signaling

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Author : Cheorl-Ho Kim
language : en
Publisher: Springer Nature
Release Date : 2020-07-10

Gm3 Signaling written by Cheorl-Ho Kim and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-10 with Medical categories.

This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.

Lipid Rafts And Caveolae

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