Cell Cycle Deregulation In Cancer
DOWNLOAD
Download Cell Cycle Deregulation In Cancer PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Cell Cycle Deregulation In Cancer book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Cell Cycle Deregulation In Cancer
DOWNLOAD
Author : Greg H. Enders
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Cell Cycle Deregulation In Cancer written by Greg H. Enders and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Medical categories.
Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (normal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy.
Cell Cycle And Growth Control
DOWNLOAD
Author : Gary S. Stein
language : en
Publisher: John Wiley & Sons
Release Date : 2004-05-24
Cell Cycle And Growth Control written by Gary S. Stein and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-05-24 with Science categories.
This comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more.
The Cell Cycle And Cancer
DOWNLOAD
Author : Renato Baserga
language : en
Publisher:
Release Date : 1971
The Cell Cycle And Cancer written by Renato Baserga and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with Medical categories.
Cell Cycle Regulation
DOWNLOAD
Author : Philipp Kaldis
language : en
Publisher: Springer
Release Date : 2010-11-18
Cell Cycle Regulation written by Philipp Kaldis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-18 with Science categories.
This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.
Molecular Mechanisms Of Cancer
DOWNLOAD
Author : Georg F. Weber
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-12
Molecular Mechanisms Of Cancer written by Georg F. Weber and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-12 with Medical categories.
This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.
Scf And Apc E3 Ubiquitin Ligases In Tumorigenesis
DOWNLOAD
Author : Hiroyuki Inuzuka
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-03-28
Scf And Apc E3 Ubiquitin Ligases In Tumorigenesis written by Hiroyuki Inuzuka and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-28 with Medical categories.
This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.
Cell Cycle Control And Dysregulation Protocols
DOWNLOAD
Author : Antonio Giordano
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Cell Cycle Control And Dysregulation Protocols written by Antonio Giordano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Medical categories.
Cell Cycle Control and Dysregulation Protocols focuses on emerging methodologies for studying the cell cycle, kinases, and kinase inhibitors. It addresses the issue of gene expression in vivo and in vitro, the analysis of cyclin-dependent kinase inhibitors, protein degradation mediated by the proteosome, the analysis of the transformed cell phenotype, and innovative techniques to detect apoptosis. Because there are already many manuals and protocols available, along with commercial kits and reagents, a variety of the more common techniques have not been included in our book. The protocols described, based on rather sophisticated techniques for in vivo and in vitro studies, consist of molecular biology, biochemistry, and various types of immunoassays. Indeed, the authors have successfully accomplished an arduous task by presenting several topics in the simplest possible manner. We are confident that Cell Cycle Control and Dysregulation Protocols will facilitate and optimize the work of practical scientists involved in researching the cell cycle. We greatly acknowledge the extraordinary contribution of the authors in writing this book.
Microrna Targeted Cancer Therapy
DOWNLOAD
Author : Fazlul H. Sarkar
language : en
Publisher: Springer Science & Business
Release Date : 2014-04-22
Microrna Targeted Cancer Therapy written by Fazlul H. Sarkar and has been published by Springer Science & Business this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-22 with Medical categories.
Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy” and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.
Rediscovering Cancer From Mechanism To Therapy
DOWNLOAD
Author : Sayali Mukherjee
language : en
Publisher: CRC Press
Release Date : 2018-09-04
Rediscovering Cancer From Mechanism To Therapy written by Sayali Mukherjee and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-04 with Medical categories.
This volume presents a snapshot of some of the most important ongoing research in cancer. With cancer as the second leading cause of death worldwide, extensive research is going on globally to decipher the molecular mechanism underlying cancer that will help in finding better targets for drug therapy. The book brings together new research on molecular mechanism and cancer therapeutics in one place. With chapters from experts in their respective fields, chapters cover molecular mechanisms, etiology, prognosis, detection, and treatment of cancer. Emphasis has been given to the intricate mechanism behind the deregulation of cell division, disruption of cell cycle check points, mutation in oncogenes and tumor suppressor genes, apoptosis, and erratic cell signaling. The book discusses in detail topics such as angiogenesis and tumor microenvironment, which are increasingly receiving attention, especially in the field of neoplastic vascularization and metastasis. The book also includes chapters detailing the current understanding and the future perspective of cancer stem cells.
Apoptosis And Cell Cycle Control In Cancer
DOWNLOAD
Author : N. Shaun B. Thomas
language : en
Publisher: Taylor & Francis
Release Date : 1996
Apoptosis And Cell Cycle Control In Cancer written by N. Shaun B. Thomas and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Science categories.
Over the past few years, there have been major breakthroughs in our understanding of the molecular mechanisms which control cell division and apoptosis (programmed cell death). This book adopts a multi-disciplinary approach to explore how the deregulation of basic molecular controls can lead to malignancy in a variety of cell types. The authors are leading international experts whose chapters span the state of the art in cell and molecular biology, clinical treatment of cancer and new drug design.