Cellular And Molecular Targets In Epileptogenesis Focusing On Disease Prevention
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Cellular And Molecular Targets In Epileptogenesis Focusing On Disease Prevention
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Author : Diana Cunha-Reis
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-01
Cellular And Molecular Targets In Epileptogenesis Focusing On Disease Prevention written by Diana Cunha-Reis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-01 with Science categories.
Neuronal Mechanisms Of Epileptogenesis
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Author : Roberto Di Maio
language : en
Publisher: Frontiers E-books
Release Date : 2015-01-13
Neuronal Mechanisms Of Epileptogenesis written by Roberto Di Maio and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-13 with Brain categories.
Several types of brain injuries are causes of acquired temporal lobe epilepsy (TLE). The seizure-free "latent period" that often follows the brain injury is of unknown mechanistic significance but is commonly considered as the "epileptogenic" period characterized by gradual pathogenic processes leading to the onset of clinically detectable epilepsy. Acute convulsive status epilepticus (SE) is often associated with an adverse developmental outcome characterized by learning disabilities related to the cumulative effects of seizures and development of TLE. The symptomatic manifestations of TLE appear only after a widespread irreversible damage of entorhinal cortex, and hippocampus, the brain area most affected by this disease. These pathological features of TLE reduce the possibility of successful therapeutic approaches, often rendering the disease refractory. The difficult clinical management of chronic TLE and the limited success rate of surgical approaches, increase the incapacitating nature of this specific epileptic disorder. Prevention of TLE with an appropriate intervention after a known inciting event (in the case of acquired epilepsy) might represent the most ambitious goal in the clinical treatment of this epileptic disorder, but has been largely unsuccessful to this point. Clinical trials aimed at prevention of chronic epilepsy have often produced negative, disappointing results. However, in most cases, these studies ultimately evaluated the downstream clinical manifestations, failing to monitor early, specific molecular epileptogenic events. Therefore, elucidation of the underlying mechanisms of epileptogenesis, and their time course(s) are essential. The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder.
Epilepsy
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Author : Jong Rho
language : en
Publisher: CRC Press
Release Date : 2010-06-18
Epilepsy written by Jong Rho and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-18 with Medical categories.
Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervo
Vascular Health The Endothelial Perspective In Regulation Of Inflammation And Injury
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Author : Shampa Chatterjee
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-01
Vascular Health The Endothelial Perspective In Regulation Of Inflammation And Injury written by Shampa Chatterjee and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-01 with Science categories.
Handbook Of Mitochondrial Dysfunction
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Author : Shamim I. Ahmad
language : en
Publisher: CRC Press
Release Date : 2019-05-15
Handbook Of Mitochondrial Dysfunction written by Shamim I. Ahmad and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-15 with Medical categories.
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.
Bk Channels Integrators Of Cellular Signals In Health And Disease
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Author : Thomas M. Weiger
language : en
Publisher: Frontiers Media SA
Release Date : 2017-11-10
Bk Channels Integrators Of Cellular Signals In Health And Disease written by Thomas M. Weiger and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-10 with categories.
Maxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in response to depolarization and/or increase in local calcium levels. Thus, voltage and calcium ions are involved in gating the channel under physiological conditions. This dual activation makes them perfect sensors for many cellular events that require integration between intracellular calcium levels and electrical signals. A plethora of physiological and pathophysiological functions, such as membrane hyperpolarization, modulation of synaptic transmission, hormone secretion or mental deficiencies, vaso-regulation, epilepsies, heart diseases, myotonic dystrophies, hypertension etc, in almost all cells and tissues were reported for these channels. BK channels are main targets for important ligands like alcohol and gaseous neurotransmitters, such as NO, CO or H2S, to name a few. In the last years, the molecular entities and mechanisms involved in modulation of BK channels have gained tremendous attention, as the key role of these channels in cellular processes became increasingly recognized. Indeed, accessory proteins such as slob, beta and gamma subunits, all serve to modulate the channel gating characteristics. Moreover, channel subunit expression and function is further tuned by phosphorylation/ dephosphorylation processes, redox mechanisms and the lipid microenvironment of the BK channel protein complex. This e-book contains structural and functional aspects of BK channels, channel modulation by a variety of agents and cellular components, as well as the channel’s relevance in health and disease.
Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases
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Author : Pukar Khanal
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-02
Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases written by Pukar Khanal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-02 with Science categories.
Neurodegenerative disorders have increasing incidence with limited treatment options. Approaches to target neuroinflammation in various neurodegenerative disorders, such as Alzheimer’s disease (AD), involve a quest for innovative therapeutics. A comprehensive understanding of the quest for small compounds that improve amyloid processing, regulate autophagy, hinder Aß accumulation, and investigate the array of phytochemicals present in naturally occurring nootropics (ethnomedicines) and polypharmacology may facilitate the exploration of diverse pharmacological approaches to impede disease advancement. Galantamine from snowdrops (Galanthus spp.) is just one example of a current core medication used in the management of cognitive decline, pointing to the potential of small molecules in this context. In addition, the combinations of computational and experimental pharmacological methods enable the exploration of small molecules within crucial neurodegenerative processes, which can help to develop potential therapeutic compounds.
Psychiatric And Behavioral Aspects Of Epilepsy
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Author : Nigel C. Jones
language : en
Publisher: Springer Nature
Release Date : 2022-05-23
Psychiatric And Behavioral Aspects Of Epilepsy written by Nigel C. Jones and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-23 with Medical categories.
Many people living with epilepsy also suffer from debilitating psychiatric and cognitive disorders. While these comorbidities have been recognized for centuries, their causation, and relationship to the epilepsy remains clouded in mystery. This volume highlights recent knowledge and findings as well as controversies in our current understanding of behavioral and psychiatric comorbidities of epilepsy.
Neurodegenerative Diseases
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Author : Shamim I. Ahmad
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-12
Neurodegenerative Diseases written by Shamim I. Ahmad and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-12 with Medical categories.
The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
Epilepsy New Insights For The Healthcare Professional 2013 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-07-22
Epilepsy New Insights For The Healthcare Professional 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-22 with Medical categories.
Epilepsy: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Epilepsy: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Epilepsy: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.