Challenges In Endocrine Disruptor Toxicology And Risk Assessment
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Challenges In Endocrine Disruptor Toxicology And Risk Assessment
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Author : Alberto Mantovani
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-12-08
Challenges In Endocrine Disruptor Toxicology And Risk Assessment written by Alberto Mantovani and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-08 with Science categories.
Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer’s disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.
Endocrine Toxicology
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Author : J. Charles Eldridge
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Endocrine Toxicology written by J. Charles Eldridge and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology's increased importance in environmental safety issues
Wildlife Ecotoxicology
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Author : John E. Elliott
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-08-27
Wildlife Ecotoxicology written by John E. Elliott and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-27 with Science categories.
Many books have now been published in the broad field of environmental toxicology. However, to date, none of have presented the often fascinating stories of the wildlife science, and the steps along the way from discovery of problems caused by environmental pollutants to the regulatory and non-regulatory efforts to address the problems. This book provides case by case examinations of how toxic chemical effects on wildlife have brought about policy and regulatory decisions, and positive changes in environmental conditions. Wild animal stories, whether they are about the disappearance of charismatic top predators, or of grossly deformed embryos or frogs, provide powerful symbols that can and have captured the public's imagination and have resulted in increased awareness by decision makers. It is the intent of this book to present factual and balanced overviews and summaries of the science and the subsequent regulatory processes that followed to effect change (or not). We cover a variety of chemicals and topics beginning with an update of the classic California coastal DDT story of eggshell thinning and avian reproduction to more recent cases, such as the veterinarian pharmaceutical that has brought three species of Asian vultures to the brink of extinction. Researchers, regulators, educators, NGOs and the general public will find valuable insights into the processes and mechanisms involved both in environmental scientific investigation and in efforts to effect positive change.
Fiscal Year 1999 Epa R D Budget Authorization
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Author : United States. Congress. House. Committee on Science. Subcommittee on Energy and Environment
language : en
Publisher:
Release Date : 1998
Fiscal Year 1999 Epa R D Budget Authorization written by United States. Congress. House. Committee on Science. Subcommittee on Energy and Environment and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Business & Economics categories.
Toxicological Risk Assessment And Multi System Health Impacts From Exposure
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Author : Aristidis M. Tsatsakis
language : en
Publisher: Elsevier
Release Date : 2021-08-05
Toxicological Risk Assessment And Multi System Health Impacts From Exposure written by Aristidis M. Tsatsakis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-05 with Medical categories.
Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research
Principles Of Toxicology
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Author : Phillip L. Williams
language : en
Publisher: John Wiley & Sons
Release Date : 2003-10-10
Principles Of Toxicology written by Phillip L. Williams and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-10 with Science categories.
A fully updated and expanded edition of the bestselling guide on toxicology and its practical application The field of toxicology has grown enormously since Industrial Toxicology: Safety and Health Applications in the Workplace was first published in 1985. And while the original edition was hugely popular among occupational health professionals, the time is ripe to address toxic agents not only in the industrial setting but also in the environment at large. Renamed Principles of Toxicology: Environmental and Industrial Applications, this new edition provides health protection professionals as well as environmental scientists with precise, up-to-date, practical information on how to apply the science of toxicology in both the occupational and environmental setting. Through contributions from leading experts in diverse fields, Principles of Toxicology, Second Edition features: Clear explanations of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems Coverage of occupational medicine and epidemiological issues The manifestation of toxic agents such as metals, pesticides, organic solvents, and natural toxins Special emphasis on the evaluation and control of toxic hazards Specific case histories on applying risk assessment methods in the modern workplace Ample figures, references, and a comprehensive glossary of toxicological terms
Information Resources In Toxicology Volume 1 Background Resources And Tools
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-05-16
Information Resources In Toxicology Volume 1 Background Resources And Tools written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-16 with Technology & Engineering categories.
This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools.Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field.The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. - Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources - Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles - Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals - Explores recent internet trends, web-based databases, and software tools in a section on the online environment - Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents - Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field
Emerging Pollutants In The Environment
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Author : Marcelo Larramendy
language : en
Publisher: BoD – Books on Demand
Release Date : 2015-09-02
Emerging Pollutants In The Environment written by Marcelo Larramendy and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-02 with Science categories.
This edited book, Emerging Pollutants in the Environment Current and Further Implications, includes overviews by significant researchers on the topic of emerging pollutants toxicology, which covers the hazardous effects of common emerging xenobiotics employed in our every day anthropogenic activities. We hope that this book will meet the expectations and needs of all those who are interested in the negative implications of several emerging pollutants on living species.
Comprehensive Toxicology
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Author :
language : en
Publisher: Elsevier
Release Date : 2017-12-01
Comprehensive Toxicology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-01 with Science categories.
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Toxicological Assessment Of Combined Chemicals In The Environment
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Author : De-Sheng Pei
language : en
Publisher: John Wiley & Sons
Release Date : 2025-01-28
Toxicological Assessment Of Combined Chemicals In The Environment written by De-Sheng Pei and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-28 with Science categories.
Comprehensive resource covering toxicology fundamentals, distribution of pollutants in the environment, and research methodologies for toxicological assessment of chemical mixtures Toxicological Assessment of Combined Chemicals in the Environment offers an in-depth exploration of various approaches and molecular mechanisms regarding how minor alterations in chemical mixtures can influence an organism’s toxicity, along with discussion of the challenges associated with assessing mixtures. The first section of the book provides a concise introduction to the background and significance of combined toxicity. Section two delves into the primary sources and enrichment mechanisms of different chemical mixtures, elucidating the biological exposure pathways of these compounds. Section three introduces both classical and emerging toxicological research models in detail. Building on the descriptions of compound emission, migration, accumulation, and transformation processes, and the analysis of combined molecular toxicity in the preceding sections, section four introduces computer mathematical modeling methods for hazard assessment of compound mixtures. The final section details the challenges and future trends in this field. Written by a highly qualified author and seasoned research contributor in the field, Toxicological Assessment of Combined Chemicals in the Environment covers sample topics including: The degradation, oxidation, absorption, distribution, biotransformation, and excretion of various compounds in both the environment and in organisms A variety of cell models and in vivo research models of model organisms, supplemented with case studies Combined molecular toxicity mechanisms of heavy metals, pesticides, persistent organic pollutants (POPs), and pharmaceutical and personal care products (PPCPs) Principal sources, fate, and mechanism of chemical mixtures in the environment, as well as experimental designs and sampling strategies for combined toxicity studies based on concentrations Toxicological Assessment of Combined Chemicals in the Environment serves as a valuable reference for researchers, students, and policymakers involved in environmental management and protection. It is particularly relevant for toxicologists, risk assessors, and those engaged in the molecular modeling of toxic mixtures.