Characterizing The Multi Faceted Dynamics Of Tumor Cell Plasticity
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Characterizing The Multi Faceted Dynamics Of Tumor Cell Plasticity
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Author : Satyendra Chandra Tripathi
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-01
Characterizing The Multi Faceted Dynamics Of Tumor Cell Plasticity written by Satyendra Chandra Tripathi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-01 with Science categories.
Revisiting Seed And Soil A New Approach To Target Hibernating Dormant Tumor Cells 2nd Edition
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Author : Dalit Barkan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-07
Revisiting Seed And Soil A New Approach To Target Hibernating Dormant Tumor Cells 2nd Edition written by Dalit Barkan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-07 with Medical categories.
Metastasis is the major cause of mortality in cancer patients. Metastases can be present at the time of diagnosis or can occur years or decades after the removal of the primary tumor and treatment. This long latency in the manifestation of recurrent metastatic disease is explained clinically by the persistence of quiescent tumor cells that disseminated early in the course of the disease from the primary tumor to select distant organs. These residing disseminated tumor cells (DTCs) at distant organs lay dormant and asymptomatic until reawakened to form overt metastases. Importantly, the quiescent nature of these “hibernating” DTCs facilitates their resistance to conventional therapies that target actively dividing tumor cells. Therefore, unraveling the biology of dormancy and reactivation of the residing DTCs to life-threatening lesions is of utmost importance in order to develop new therapeutic strategies to prevent the recurrent metastatic disease from ever emerging or to better treat these recurrent cancers. The mechanisms underlying the biology of tumor dormancy and their reactivation to overt metastases are just beginning to emerge thanks to a growing appreciation of the potentially chronic nature of some cancers and the development of experimental model systems for their study. In this Research Topic, we will follow the journey of circulating tumor cells (CTCs) dispatching from the primary site until their successful lodging into a new and foreign site to become DTCs. We will explore the intrinsic mechanisms along with microenvironmental cues and niches that they encounter during their journey that may dictate their fate.
Epithelial Mesenchymal Plasticity In Cancer Metastasis
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Author : Mohit Kumar Jolly
language : en
Publisher: MDPI
Release Date : 2020-12-29
Epithelial Mesenchymal Plasticity In Cancer Metastasis written by Mohit Kumar Jolly and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-29 with Medical categories.
Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.
Non Lymphoid Functions Of Regulatory T Cells In Health And Disease
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Author : Dipayan Rudra
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-01
Non Lymphoid Functions Of Regulatory T Cells In Health And Disease written by Dipayan Rudra and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-01 with Medical categories.
The Multifaceted Roles Of Lipids In Physiological And Pathophysiological States
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Author : Simona Lobasso
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-23
The Multifaceted Roles Of Lipids In Physiological And Pathophysiological States written by Simona Lobasso and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-23 with Science categories.
Cellular Dormancy State Determination And Plasticity
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Author : Guang Yao
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-15
Cellular Dormancy State Determination And Plasticity written by Guang Yao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-15 with Science categories.
Mitochondrial Plasticity And Quality Control In Health And Disease
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Author : Milena Rizzo
language : en
Publisher: Frontiers Media SA
Release Date : 2024-08-14
Mitochondrial Plasticity And Quality Control In Health And Disease written by Milena Rizzo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-14 with Science categories.
Encyclopedia Of Inland Waters
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Author :
language : en
Publisher: Academic Press
Release Date : 2009-01-13
Encyclopedia Of Inland Waters written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-13 with Science categories.
Inland aquatic habitats occur world-wide at all scales from marshes, swamps and temporary puddles, to ponds, lakes and inland seas; from streams and creeks to rolling rivers. Vital for biological diversity, ecosystem function and as resources for human life, commerce and leisure, inland waters are a vital component of life on Earth. The Encyclopedia of Inland Waters describes and explains all the basic features of the subject, from water chemistry and physics, to the biology of aquatic creatures and the complex function and balance of aquatic ecosystems of varying size and complexity. Used and abused as an essential resource, it is vital that we understand and manage them as much as we appreciate and enjoy them. This extraordinary reference brings together the very best research to provide the basic and advanced information necessary for scientists to understand these ecosystems – and for water resource managers and consultants to manage and protect them for future generations. Encyclopedic reference to Limnology - a key core subject in ecology taught as a specialist course in universitiesOver 240 topic related articles cover the field Gene Likens is a renowned limnologist and conservationist, Emeritus Director of the Institute of Ecosystems Research, elected member of the American Philosophical Society and recipient of the 2001 National Medal of Science Subject Section Editors and authors include the very best research workers in the field
Cancer Immunotherapy Principles And Practice Second Edition
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Author : Lisa H. Butterfield
language : en
Publisher: Springer Publishing Company
Release Date : 2021-08-25
Cancer Immunotherapy Principles And Practice Second Edition written by Lisa H. Butterfield and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-25 with Medical categories.
Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs
Unveiling Biomarkers And Mechanisms In The Tumor Immune Nexus
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Author : Wantao Wu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-20
Unveiling Biomarkers And Mechanisms In The Tumor Immune Nexus written by Wantao Wu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-20 with Medical categories.
The interplay between cancer cells and the immune system is a critical area of research, with recent advancements highlighting the potential of immunotherapy in offering durable responses across various cancer types. Immune checkpoint inhibitors, in particular, have emerged as a cornerstone of cancer therapy, transforming patient outcomes. However, the heterogeneity of tumor-immune interactions poses significant challenges, with a considerable fraction of patients not responding to such treatments. This underscores the urgent need for a deeper understanding of the molecular and cellular underpinnings of these interactions, to harness the full potential of immunotherapy. This Research Topic aims to address the complex landscape of tumor-immune interactions, focusing on identifying and leveraging novel biomarkers and mechanisms that can predict and enhance the efficacy of immunotherapy. Given the pivotal role of the immune system in controlling and eradicating cancer, understanding these interactions at a granular level could lead to more personalized and effective treatment strategies. Recent advances in technologies such as next-generation sequencing, single-cell RNA sequencing, and mass cytometry have opened new avenues for dissecting the complexity of the tumor microenvironment and immune evasion strategies. This collection seeks to compile cutting-edge research that employs these technologies to uncover new biomarkers, understand resistance mechanisms, and identify potential therapeutic targets within the immune contexture of tumors. By bridging gaps in knowledge and fostering innovation, this topic aims to propel the field towards more predictive and responsive immunotherapy approaches.