Chemical Exposure And Toxic Responses
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Chemical Exposure And Toxic Responses
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Author : Stephen K. Hall
language : en
Publisher: CRC Press
Release Date : 2020-07-24
Chemical Exposure And Toxic Responses written by Stephen K. Hall and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-24 with Science categories.
Providing material for practitioners and students alike, Chemical Exposure and Toxic Responses is a clear and straightforward presentation of industrial toxicology. Exposure to toxic chemicals is of major concern to health professionals. In recent years, the scope and importance of hazardous materials toxicology has expanded and now impacts financial institutions, government, private corporations, and many other organizations as well. Chemical Exposure and Toxic Responses presents the myriad health implications of hazardous chemicals in a single source. This book is organized so that readers can proceed from a general perspective on the problem of chemical exposure and toxic responses to an understanding of toxicology and a method of inquiry. Written for anyone who needs practical toxicological information, the book compactly and efficiently presents the scientific basis of toxicology as it applies to the workplace. It covers the diverse chemical hazards encountered in the work environment and provides a practical understanding of these hazards for those charged with protecting the health and well being of people at work. Chemical Exposure and Toxic Responses consists of three parts: Part I establishes the general principles of industrial toxicology; Part II addresses specific effects of toxic agents on specific physiological organs and systems; and Part III is devoted to the evaluation of hazards in the workplace.
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment
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Author : David A. Eckerman
language : en
Publisher: CRC Press
Release Date : 1998-08-25
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment written by David A. Eckerman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-25 with Medical categories.
and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
Human Variability In Response To Chemical Exposures
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Author : David A. Neumann
language : en
Publisher: International Life Science Inst
Release Date : 1998
Human Variability In Response To Chemical Exposures written by David A. Neumann and has been published by International Life Science Inst this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, & Risk Assessment recognizes & addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive & developmental effects, effects on the nervous system & lungs, & cancer. Their reports convey both the current state of scientific understanding of response variability & the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community & others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed & illustrated with published data. This authoritative work indicates that, in the case of certain chemicals & in the context of certain specific toxic effects, we have considerable ability to predictively & quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity & quality of information available on response variability & increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment
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Author : David A. Neumann
language : en
Publisher: CRC Press
Release Date : 1998-08-25
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment written by David A. Neumann and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-25 with Medical categories.
and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
Monitoring Human Tissues For Toxic Substances
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1991-02-01
Monitoring Human Tissues For Toxic Substances written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-02-01 with Science categories.
The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.
Handbook Of Chemicals And Safety
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Author : T.S.S. Dikshith
language : en
Publisher: CRC Press
Release Date : 2010-11-02
Handbook Of Chemicals And Safety written by T.S.S. Dikshith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-02 with Science categories.
A host of chemical substances have become essential parts of human activities and requirements for societal development. Any kind of misuse and/or negligence in handling these substances can cause health disorders, poisoning, and fatalities among unprotected workers and members of the public exposed to contaminated food, water, and air. Carefully organized for ease of use, Handbook of Chemicals and Safety provides a tool for the management of a range of chemical substances commonly used, handled, stored, transported, and disposed of as wastes. Written in an accessible style with just the right amount of technical rigor, the book covers: General fundamentals and specific hazards and effects of chemical substances The basics of exposures and responses to chemical substances in the work environment Toxic responses in different body systems General perspective on the problem of chemical exposures and the possible health effects The author includes substances such as industrial solvents, pesticides, metals, air pollutants, toxic gases, drugs, and other items. He supplies the chemical abstract system (CAS) number, IUPAC name, molecular formula, synonyms and trade names, use and exposure, toxicity and health effects, and carcinogen factors. He also includes information on exposure limits, methods of proper storage, and waste disposal. An important reference on exposure to different categories of chemical substances, the book stresses the importance of preparedness in any safety program. Taking a broad and interdisciplinary approach to chemicals and workplace safety, it provides guidance on the judicious management of chemical substances.
Science And Judgment In Risk Assessment
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1994-01-01
Science And Judgment In Risk Assessment written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-01 with Science categories.
The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.
Acute Exposure Guideline Levels For Selected Airborne Chemicals
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2001-01-10
Acute Exposure Guideline Levels For Selected Airborne Chemicals written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-10 with Science categories.
In the Bhopal disaster of 1984, approximately 2,000 residents living near a chemical plant were killed and 20,000 more suffered irreversible damage to their eyes and lungs following the accidental release of methyl isocyanate. This tragedy served to focus international attention on the need for governments to identify hazardous substances and assist local communities in planning how to deal with emergency exposures. Since 1986, the U.S. Environmental Protection Agency has been tasked with identifying extremely hazardous substances and, in cooperation with the Federal Emergency Management Agency and the Department of Transportation, assist local emergency response planners. The National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances was established in 1995 to develop acute exposure guideline levels (AEGLs) for high priority toxic chemicals that could be released into the air from accidents at chemical plants, storage sites, or during transportation. This book reviews toxicity documents on five chemicals--chlorine, hydrogen chloride, hydrogen fluoride, toluene, and uranium hexafluoride--for their scientific validity, comprehensives, internal consistency, and conformance to the 1993 guidelines report.
Biological Monitoring Of Exposure And The Response At The Subcellular Level To Toxic Substances
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Author : Philip L. Chambers
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biological Monitoring Of Exposure And The Response At The Subcellular Level To Toxic Substances written by Philip L. Chambers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This supplement contains the papers submitted at EUROTOX 88, the joint Congress of the European Society of Toxicology and the Federation of the European Societies of Toxicology. The theme was one of monitoring and examining the effects of toxic substances in the biological response at the subcellular level. Mechanisms of metal carcinogenicity are discussed as well as the biomonitoring of chemical exposure. Reports are provided on the role of individual differences in man and the effect of risk assessment. Papers appear dealing with the genetic control of drug metabolizing enzymes. The role of metabolism in organic specific toxicity is discussed. Information is included on the toxicological impact of chemicals interfering with the endocrine system as well as on the effects of toxicants on the immune system. Presentations deal with the current status of risk assessment in environmental toxicology.
Hazardous Chemicals Handbook
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Author : P A CARSON
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Hazardous Chemicals Handbook written by P A CARSON and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Technology & Engineering categories.
Summarizes core information for quick reference in the workplace, using tables and checklists wherever possible. Essential reading for safety officers, company managers, engineers, transport personnel, waste disposal personnel, environmental health officers, trainees on industrial training courses and engineering students. This book provides concise and clear explanation and look-up data on properties, exposure limits, flashpoints, monitoring techniques, personal protection and a host of other parameters and requirements relating to compliance with designated safe practice, control of hazards to people's health and limitation of impact on the environment. The book caters for the multitude of companies, officials and public and private employees who must comply with the regulations governing the use, storage, handling, transport and disposal of hazardous substances. Reference is made throughout to source documents and standards, and a Bibliography provides guidance to sources of wider ranging and more specialized information. Dr Phillip Carson is Safety Liaison and QA Manager at the Unilever Research Laboratory at Port Sunlight. He is a member of the Institution of Occupational Safety and Health, of the Institution of Chemical Engineers' Loss Prevention Panel and of the Chemical Industries Association's `Exposure Limits Task Force' and `Health Advisory Group'. Dr Clive Mumford is a Senior Lecturer in Chemical Engineering at the University of Aston and a consultant. He lectures on several courses of the Certificate and Diploma of the National Examining Board in Occupational Safety and Health. [Given 5 star rating] - Occupational Safety & Health, July 1994 - Loss Prevention Bulletin, April 1994 - Journal of Hazardous Materials, November 1994 - Process Safety & Environmental Prot., November 1994