Chimeric Toxins
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Chimeric Toxins
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Author : Haya Lorberboum-Galski
language : en
Publisher: CRC Press
Release Date : 2002-05-30
Chimeric Toxins written by Haya Lorberboum-Galski and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-05-30 with Medical categories.
Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells, such as binding to specific surface receptors, internalizati
Genetically Engineered Toxins
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Author : Arthur Frankel
language : en
Publisher: CRC Press
Release Date : 2020-08-26
Genetically Engineered Toxins written by Arthur Frankel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Science categories.
Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Reviewing difficult problems and their solutions, Genetically Engineered Toxins discusses techniques for clo;ning, expressing, and purifying recombinant toxins and genetically modified recombinant toxins; documents structure-function relationships in toxins, including comparative information; supplies theory and illustrations of chimeric toxins; delineates the preclinical assessments of new reagents; and summarizes approaches to drug design.;With over 1100 literature citations, Genetically Engineered Toxins is an invaluable resource for biochemists, molecular biologists, biotechnologists, pharmacologists, toxicologists, X-ray crystallographers, enzymologists, oncologists, hematologists, immunologists, rheumatologists, botanists, and graduate-level students in molecular biology, biotechnology, and clinical oncology courses.
Bacterial Toxins
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Author : Klaus Aktories
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-26
Bacterial Toxins written by Klaus Aktories and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-26 with Science categories.
This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.
Receptor Mediated Binding And Internalization Of Toxins And Hormones
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Author : John Middlebrook
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Receptor Mediated Binding And Internalization Of Toxins And Hormones written by John Middlebrook and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Receptor-Mediated Binding and Internalization of Toxins and Hormones presents the proceedings of a conference conducted for the purpose of exploring relationships between hormones and toxins, specifically, receptor-mediated internalization of toxins and hormones and the role of this internalization in message transmission and biodegradatory processes. This book is divided into three sections, with the first focusing on model systems of internalization. It presents pictorial illustrations of the receptor-mediated endocytosis of low-density lipoprotein via coated regions of membrane and discusses the receptor for lysosomal enzymes on the surface of cultured fibroblasts. The second section focuses on toxins and hormones and discusses such topics as receptor-mediated internalization of diphtheria toxin, diphtheria toxin interactions with an inhibitory activity from plasma membranes, and uptake mechanisms for ADP-ribosylating toxins. The third and final section focuses on hybrids and discusses such topics as chimeric toxins containing fragment A from diphtheria toxin, directed entry of hybrid proteins into cells via alternate receptors, and a hybrid protein of monoclonal anti-THY 1.2 and diphtheria toxin fragment A. This book will be of interest to practitioners in the fields of endocrinology, cell biology, and molecular genetics.
Toxins And Signal Transduction
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Author : Yehuda Gutman
language : en
Publisher: CRC Press
Release Date : 1997-05-22
Toxins And Signal Transduction written by Yehuda Gutman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-22 with Science categories.
Of the multitude of toxins known and the enormous variety of effects they cause, of particular interest are those that influence signal transduction. Intercellular communication by chemical signals is essential for the functioning of multicellular organisms. Many toxins exert their biological effects by interfering with the signal transduction initiated by these chemicals (hormones, transmitters, growth factors, and other mediators). Up-to-date information is provided by outstanding experts, who discuss the molecular mechanisms involved in the action of many toxins, as well as the use of toxins as informative tools with which to study signal transduction and their potential therapeutic usage. This volume contains useful information for the experimentalist interested in toxins or in signal transduction, as well as for the reader interested in gaining a comprehensive overview of the field. The Cellular and Molecular Mechanisms of Toxin Action series will include monographs on signal transduction, secretory systems, cytoskeleton, selective neurotoxicity of natural, recombinant and chimeric toxins giving a broader emphasis on the mechanism of action, structure-function relationship, and use of toxins as research tools and their therapeutic applications.
Toxin And Immunotoxin Based Therapeutic Approaches
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Author : Massimo Bortolotti
language : en
Publisher:
Release Date : 2022-01-29
Toxin And Immunotoxin Based Therapeutic Approaches written by Massimo Bortolotti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-29 with categories.
In 1900, Paul Ehrlich, who was studying ricin and abrin at the time, discovered antibodies and paved the way for immunotherapy. After 120 years, Ehrlich's insight into the therapeutic potential of immunotargeting is still a source of inspiration for many scientists. One of the most studied antibody-based targeting strategies is the carrying of powerful toxins. The generated molecules are immunotoxins, i.e., chimeric proteins obtained by coupling bacterial or plant toxins and antibodies through chemical linking or genetic engineering. Immunotoxins are functionally designed to eliminate the cells responsible for pathological conditions, and they find applications in several fields, ranging from cancer to immunological diseases or pain control. Despite the lack of specificity, even native toxins find clinical application, but the use of unconjugated toxins is limited to loco-regional treatments. A fundamental requirement for the medical application of toxins and their immunoconjugates is in-depth knowledge of their interaction with target cells in terms of binding, uptake, intracellular routing, and substrate specificity. This Special Issue focuses on toxins and immunotoxins that have clinical potential. We hope to give the reader a comprehensive overview of new toxin delivery strategies and toxin-based experimental disease models, both in vitro and in vivo.
Chimeric Rna
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Author : Hui Li
language : en
Publisher: Humana
Release Date : 2020-11-28
Chimeric Rna written by Hui Li and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-28 with Science categories.
This book provides numerous methods for identification, validation, and functional characterization of chimeric RNAs, herein described as any transcript which contains the nucleotide sequence of two distinct parental genes. Beginning with identification and characterization through bioinformatics tools, the book continues with experimental validation using RT-PCR, hybridization methods for RNA, and the use of mass spectrometry data for fusion protein validation, as well as functional and mechanistic studies of chimeric RNAs and translational applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Chimeric RNA: Methods and Protocols is an ideal guide to this expansive field and an inspiration to researchers seeking to further our knowledge of these remarkable features of the transcriptome.
Bacterial Toxins Advances In Research And Application 2013 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-06-21
Bacterial Toxins Advances In Research And Application 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-21 with Medical categories.
Bacterial Toxins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Botulinum Toxins. The editors have built Bacterial Toxins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Botulinum Toxins in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bacterial Toxins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Neurotoxins
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2013-10-22
Neurotoxins written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
The exquisite simplicity and potency of toxins have made them valuable probes of neural systems. This book presents a comprehensive compilation of techniques used for the preparation, handling, and, particularly, for the use of neurotoxins. Model systems are described in which these neurotoxins have been extremely valuable in developing an understanding of the cellular and molecular basis of secretion and electrophysiological events leading to altered cell function. Convenient benchtop format Methods presented for easy adaptation to new systems A virtual "A-B-C" of commonly used and available toxins Comprehensive protocols included for the use of alpha toxin, apamin, batrachotoxin; botulina toxin, bungarotoxin; channel ligands: agonists and antagonists; capsaicin; charybdotoxin, ciguatoxin; Clostridium botulinum neurotoxin; cholera toxin (choleragen); conotoxin; dendrotoxin; endothelin; fasciculin; geographutoxin; latrotoxin; natural toxins; neosurgatoxin; palytoxin; pertussis toxin; resiniferatoxin; sarafotoxin; scorpion toxin; snake venom toxins
Enterotoxins Microbial Proteins And Host Cell Dysregulation
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Author : Teresa Krakauer
language : en
Publisher: MDPI
Release Date : 2018-10-01
Enterotoxins Microbial Proteins And Host Cell Dysregulation written by Teresa Krakauer and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-01 with Electronic book categories.
This book is a printed edition of the Special Issue "Enterotoxins: Microbial Proteins and Host Cell Dysregulation" that was published in Toxins