Cis Transgene Optimization

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Cis Transgene Optimization

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Author : Saeid Kadkhodaei
language : en
Publisher: Springer
Release Date : 2018-05-16

Cis Transgene Optimization written by Saeid Kadkhodaei and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-16 with Science categories.

This book is a practical review which focuses on computational analysis and on in silico approaches towards the systematic discovery of various key functional gene expression elements in microalgae as a model. So far, in this regard very little information is available. Efficient stepwise procedures for analysing the matrix attachment regions (MARs) are outlined, as well as for translation initiation sites (TIS), signal peptide (SP) sequences, gene optimization and transformation systems. These outlines can be efficiently deployed as practical models for the systematic discovery of key expression elements and for the optimization of cis/transgenes in other micro/organisms. The first chapter is an introduction on the key gene expression elements analysed in this book, including scaffold/matrix attachment regions, translation initiation sites, signal peptides as well as gene optimization. Chapter 2 focuses on systematic strategies and computational approaches toward in silico analysis of each factor. The analyses outcomes is assessed individually in chapter 3 followed by developing the specific conceptual models for each element in Chapter 4. The concluding remarks are discussed in Chapter 5. This work is of interest to computational and experimental biologists interested in transcriptional regulation analysis as well as to researchers and scientists who wish to consider the use of bioinformatics and computational biology in design, analysis, or regulatory reviews of key gene expression elements for the production of recombinant proteins experiments.

Optimizing Plant Health Under Abiotic Stress Environments

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Author : M. Iqbal R. Khan
language : en
Publisher: CRC Press
Release Date : 2025-08-07

Optimizing Plant Health Under Abiotic Stress Environments written by M. Iqbal R. Khan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-07 with Science categories.

Abiotic stresses negatively affect crop yields, and crop health is essential to ensuring global food security. There exists an urgent need to develop more abiotic stress-resistant and -tolerant crop varieties to ensure food and nutritional security. Optimizing Plant Health under Abiotic-Stress Environments: Ensuring Food and Nutritional Security presents a comprehensive review of important mineral nutrients in plants and effective management strategies under abiotic stress environments. The optimization of significant traits for abiotic stress tolerance creates effective breeding programs contributing to the development of next-generation crop varieties. FEATURES: Discusses plant breeding and using biotechnological approaches to address the issue of food and nutritional security Presents information on how mineral nutrient homeostasis influences plant growth, nutrient enhancement, and crop yield under abiotic stresses Contains information on biofortification, QTL mapping, Genome-Wide Association Studies (GWAS), and genetic analysis for improving nutritional value of plants Covers agronomical, breeding, physiological, molecular, and biotechnological approaches to promoting yields and enhanced nutrient availability for crop improvement Optimizing Plant Health under Abiotic-Stress Environments: Ensuring Food and Nutritional Security is ideal for researchers and scientists looking for guidance on ways to improve agricultural productivity and useful for plant breeders; agriculturalists; and students.

Muscle Gene Therapy

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Author : Dongsheng Duan
language : en
Publisher: Springer
Release Date : 2019-03-30

Muscle Gene Therapy written by Dongsheng Duan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-30 with Medical categories.

About 7 million people worldwide are suffering from various inherited neuromuscular diseases. Gene therapy brings the hope of treating these diseases at their genetic roots. Muscle Gene Therapy is the only book dedicated to this topic. The first edition was published in 2010 when the field was just about to enter its prime time. The progress made since then has been unprecedented. The number of diseases that have been targeted by gene therapy has increased tremendously. The gene therapy toolbox is expanded greatly with many creative novel strategies (such as genome editing and therapy with disease-modifying genes). Most importantly, clinical benefits have begun to emerge in human patients. To reflect rapid advances in the field, we have compiled the second edition of Muscle Gene Therapy with contributions from experts that have conducted gene therapy studies either in animal models and/or in human patients. The new edition offers a much needed, up-to-date overview and perspective on the foundation and current status of neuromuscular disease gene therapy. It provides a framework to the development and regulatory approval of muscle gene therapy drugs in the upcoming years. This book is a must-have for anyone who is interested in neuromuscular disease gene therapy including those in the research arena (established investigators and trainees in the fields of clinical practice, veterinary medicine and basic biomedical sciences), funding and regulatory agencies, and patient community.

Cisgenics And Transgenics

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Author : Bhupendra Koul
language : en
Publisher: Springer Nature
Release Date : 2022-08-31

Cisgenics And Transgenics written by Bhupendra Koul and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-31 with Technology & Engineering categories.

This book presents up-to-date information on various vector-less/direct (physical, chemical) and vector-mediated/indirect (Agrobacterium-mediated) plant transformation techniques. It summarizes various strategies that facilitate a gene from lower organism to be expressed in higher plants and also in silico designing of synthetic gene for higher expression. It also highlights the importance of strong promoters to drive the expression of transgene(s). This book encompasses the advantages and drawbacks of cisgenesis and transgenesis, their implications towards sustainable crop improvement, and their future prospects. The importance, limitations, challenges, recent developments, and future prospects of molecular pharming is also discussed. The book concludes with a chapter that summarizes the major contribution of GM-crops towards global food security and economy, advances in genome editing for crop improvement, challenges and risk associated with the release of GM-crops, and the future of GM technology. This book is meant for students and researchers in the field of life sciences, food science, and agriculture.

Omics Applications In Crop Science

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Author : Debmalya Barh
language : en
Publisher: CRC Press
Release Date : 2013-12-16

Omics Applications In Crop Science written by Debmalya Barh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-16 with Medical categories.

Merging topical data from recently published review and research articles, as well as the knowledge and insight of industry experts, Omics Applications in Crop Science delves into plant science, and various technologies that use omics in agriculture. This book concentrates on crop breeding and environmental applications, and examines the applicatio

Safety And Efficacy Of Gene Based Therapeutics For Inherited Disorders

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Author : Nicola Brunetti-Pierri
language : en
Publisher: Springer
Release Date : 2017-05-22

Safety And Efficacy Of Gene Based Therapeutics For Inherited Disorders written by Nicola Brunetti-Pierri and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with Medical categories.

In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields.

Cell Culture Engineering And Technology

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Author : Ralf Pörtner
language : en
Publisher: Springer Nature
Release Date : 2022-02-20

Cell Culture Engineering And Technology written by Ralf Pörtner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-20 with Medical categories.

This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.

Multi Omics Technologies For Optimizing Synthetic Biomanufacturing

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Author : Young-Mo Kim
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-31

Multi Omics Technologies For Optimizing Synthetic Biomanufacturing written by Young-Mo Kim and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-31 with Science categories.

Translational Bioinformatics

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Author :
language : en
Publisher: Elsevier
Release Date : 2024-03-06

Translational Bioinformatics written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-06 with Science categories.

Translational Bioinformatics is an emerging field in the direction of biomedical research. High throughput technologies can be applied to the generated biological data to develop the vaccine and personalized medicine. This volume consists of the chapters from different stalwart of the field covering the topics such as drug development, vector engineering, vaccine development and translational genomics. Chapters covered in this volume discuss the translational research related with cancer, Alzheimer disease and cardiovascular diseases. This volume includes the chapter describing the importance of computational resources and chemoinformatics for the translational health research. How Omics studies are helping to translate the laboratory data into the development of tools which are beneficial in the clinics have been described. How translational bioinformatics helpful in plant genomics to improve the crops have also been included in this volume. This volume has a chapter which describes the secrets of resistance development and further how these resistance are associated with human infectious diseases. This volume will be useful to the early career researcher in the development of research idea and develop their methodologies in the direction of bioinformatics and it will also give the insight to translate their findings. - Translational Bioinformatics - Health Informatics - Multi-omics

Site Directed Insertion Of Transgenes

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Author : Sylvaine Renault
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-30

Site Directed Insertion Of Transgenes written by Sylvaine Renault and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-30 with Science categories.

The post-genomic era has brought new challenges and opportunities in all fields of the biology. In this context, several genome engineering technologies have emerged that will help deciphering genes function by as well as improve gene therapy strategies. Genomic modifications such as knock-in, knock-out, knock-down, sequence replacement or modification can today be routinely performed. However, in front of this large palette of methodologies scientists may experience difficulties to gather useful information’s scattered within the literature. This book aims to present the state of this field from basic mechanisms of site-directed modifications to their applications in a wide range of organisms such as bacteria, yeast, plants, insects, mammals. It will discuss the problems encountered when using the random integration strategy and present the recent advances made in targeted genome modification. Technologies based on Zinc Finger nucleases, Meganucleases, TALEN, CRE and FLP recombinase, C31 integrase, transposases and resolvases are fully detailed with their strengths and weaknesses. All these information’s will help students and experienced researchers to understand and choose the best technology for their own purposes.