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Computational Approaches For Biomarker Detection And Precision Therapeutics In Cancers


Computational Approaches For Biomarker Detection And Precision Therapeutics In Cancers
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Computational Approaches For Biomarker Detection And Precision Therapeutics In Cancers


Computational Approaches For Biomarker Detection And Precision Therapeutics In Cancers
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Author : Suman Ghosal
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-07

Computational Approaches For Biomarker Detection And Precision Therapeutics In Cancers written by Suman Ghosal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-07 with Science categories.




Essentials Of Cancer Genomic Computational Approaches And Precision Medicine


 Essentials Of Cancer Genomic Computational Approaches And Precision Medicine
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Author : Nosheen Masood
language : en
Publisher: Springer Nature
Release Date : 2020-03-20

Essentials Of Cancer Genomic Computational Approaches And Precision Medicine written by Nosheen Masood and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-20 with Medical categories.


This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.



Computational Immunology


Computational Immunology
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Author : Shyamasree Ghosh
language : en
Publisher: CRC Press
Release Date : 2020-01-31

Computational Immunology written by Shyamasree Ghosh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-31 with Medical categories.


Computational Immunology: Applications focuses on different mathematical models, statistical tools, techniques, and computational modelling that helps in understanding complex phenomena of the immune system and its biological functions. The book also focuses on the latest developments in computational biology in designing of drugs, targets, biomarkers for early detection and prognosis of a disease. It highlights the applications of computational methods in deciphering the complex processes of the immune system and its role in health and disease. This book discusses the most essential topics, including Next generation sequencing (NGS) and computational immunology Computational modelling and biology of diseases Drug designing Computation and identification of biomarkers Application in organ transplantation Application in disease detection and therapy Computational methods and applications in understanding of the invertebrate immune system S Ghosh is MSc, PhD, PGDHE, PGDBI, is PhD from IICB, CSIR, Kolkata, awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.



Experimental And Computational Methods In The Development Of Diagnostics And Therapeutics For Colon Cancer


Experimental And Computational Methods In The Development Of Diagnostics And Therapeutics For Colon Cancer
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Author :
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-03

Experimental And Computational Methods In The Development Of Diagnostics And Therapeutics For Colon Cancer written by and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-03 with Science categories.


Cancer continues to be one of the major causes of illness and death worldwide. Cancer is growing at a shocking speed and touches every geographic region of the world. It is predicted that by 2030 there will be 21.7 million new cases and 13 million deaths. To overcome this problem efficiently and to make significant progress in cancer research and therapy, both the scientific and healthcare sectors must work together. Recent advancements in the development of AI-based methods i.e. ensemble or stacking algorithms to discover novel biomarkers using gene expression and other data provide greater opportunity for complete data analysis to decipher the mechanism of colon cancer initiation, progression, and metastasis. In cancer therapy and precision medicine, drug discovery is critical. The surge of omics data over the previous decade has allowed for experimental and computational prediction of anti-cancer therapies and enhanced drug discovery. The goal is therefore to both experimentally and computationally investigate the novel biomarkers in the development of colon cancer and drug resistance. Then, novel drug targets (biomarkers) may help to overcome the problem of drug resistance in cancer. The most advanced experimental and computational techniques, particularly using artificial intelligence and machine learning methods, can be implemented to predict the structural implications of mutations. This will be beneficial in understanding mechanisms of drug resistance and the discovery of novel biomarkers and drugs.



Computational Methods In Drug Discovery And Repurposing For Cancer Therapy


Computational Methods In Drug Discovery And Repurposing For Cancer Therapy
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Elsevier
Release Date : 2023-03-22

Computational Methods In Drug Discovery And Repurposing For Cancer Therapy written by Ganji Purnachandra Nagaraju and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-22 with Computers categories.


Computational Methods in Drug Discovery and Repurposing for Cancer Therapy provides knowledge about ongoing research as well as computational approaches for drug discovery and repurposing for cancer therapy. The book also provides detailed descriptions about target molecules, pathways, and their inhibitors for easy understanding and applicability. The book discusses tools and techniques such as integrated bioinformatics approaches, systems biology tools, molecular docking, computational chemistry, artificial intelligence, machine learning, structure-based virtual screening, biomarkers, and transcriptome; those are discussed in the context of different cancer types, such as colon, pancreatic, glioblastoma, endometrial, and retinoblastoma, among others. This book is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about the use of computational modeling to better tailor the treatment for cancer patients. - Discusses in silico remodeling of effective phytochemical compounds for discovering improved anticancer agents for substantial/significant cancer therapy - Covers potential tools of bioinformatics that are applied toward discovering new targets by drug repurposing and strategies to cure different types of cancers - Demonstrates the significance of computational and artificial intelligence approaches in anticancer drug discovery - Explores how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care



Ai Assisted Computational Approaches For Immunological Disorders


Ai Assisted Computational Approaches For Immunological Disorders
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Author : Chen, Jen-Tsung
language : en
Publisher: IGI Global
Release Date : 2025-05-13

Ai Assisted Computational Approaches For Immunological Disorders written by Chen, Jen-Tsung and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-13 with Medical categories.


Based on accelerated computing and advanced algorithms, artificial intelligence (AI) has become a game-changer in diverse fields. In biomedical science, AI models based on machine learning, deep learning, and generative AI, together with upgraded computational and systems biology, provide smart, precise, and personalized medicine and healthcare. In the field of clinical immunology, which deals with intrinsic complicated immune systems for combating immunological disorders, AI technologies have the potential to solve problems based on identification, prediction, simulation, and modeling. AI algorithms may impact sustainable clinical healthcare and future immunology diagnoses. AI-Assisted Computational Approaches for Immunological Disorders explores precision clinical medicine and personalized healthcare in major immunological disorders, such as immunodeficiency, autoimmune diseases, allergies, asthma, cancers, and neurological diseases. It analyzes clinical healthcare big data, genomics, and high-throughput multiple omics based on single-cell and high-dimensional data for their technical advances, clinical applications, challenges, and future directions. Covering topics such as cell therapy, reducing complications, and drug development, this book is an excellent resource for immunologists, biologists, healthcare practitioners, professionals, researchers, scholars, academicians, and more.



Multi Omics Technology In Human Health And Diseases


Multi Omics Technology In Human Health And Diseases
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Author : Muzafar A Macha
language : en
Publisher: Elsevier
Release Date : 2025-03-17

Multi Omics Technology In Human Health And Diseases written by Muzafar A Macha and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-17 with Science categories.


Multi-Omics Technology in Human Health and Diseases: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Radiomics, Multi-omic provides a way forward in understanding complete disease etiology and prognosis. This unique book gives a comprehensive understanding of multi-omics technology and its applications in understanding complex human health and disease and not only introduces the technology, but also its use for biomarker identification, drug discovery, and disease prognostication. A comprehensive understanding of human health and diseases, particularly cancer, requires knowledge of molecular biomarkers at a multi-omics level, including genome, epigenome, transcriptome, proteome, and metabolome, which is meagerly available or highly lacking among the students and scientific researchers. This book covers all the aspects of multi-omics technology and how this technology can be implemented into scientific research and discovery.Multi-Omics Technology in Human Health and Diseases: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Radiomics, Multi-omic is the first resource to present the latest information on currently utilized multi-omics technology for big data interpretation and their applications in understanding the complex human pathobiology. This is the perfect resource for researchers, academia, students, as well as the industrial audience. - Presents the most recent advancements in multiomics technology for elucidating complex human pathobiology. - Offers comprehensive insights into understanding disease etiology and prognosis. - Introduces the principles of multiomics technology and its applications in biomarker identification, drug discovery, and disease prognostication. - Explores the tools and methodologies for integrating and interpreting multiomics data sets. - Introduces multiomics databases and visualization web portals. - Provides up-to-date information on the role of multiomics technology in understanding intricate human pathobiology.



Theranostics And Precision Medicine For The Management Of Hepatocellular Carcinoma Volume 2


Theranostics And Precision Medicine For The Management Of Hepatocellular Carcinoma Volume 2
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Academic Press
Release Date : 2022-04-02

Theranostics And Precision Medicine For The Management Of Hepatocellular Carcinoma Volume 2 written by Ganji Purnachandra Nagaraju and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-02 with Psychology categories.


Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume Two: Diagnosis, Therapeutic Targets and Molecular Mechanisms for Hepatocellular Carcinoma Progression provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. The volume discusses topics such as computational approaches for identification of biomarkers, enzymes and pathways of HCC, circulating and epigenetic biomarkers, drug resistance, metabolic pathways, and small molecule-target therapies. In addition, it discusses immunotherapies, immune check point inhibitors and nanotechnology-based therapies. This book is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting. - Provides detailed information on traditional and novel diagnostic tools for hepatocellular carcinoma - Discusses promising targeted therapies, both available and in development, explaining the best option to use for specific cases - Brings recent findings in immunotherapies, immune checkpoint inhibitors and nanotechnology-based therapeutic approaches for treatment of HCC



Bioinformatics In Cancer And Cancer Therapy


Bioinformatics In Cancer And Cancer Therapy
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Author : Gavin J. Gordon
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-10-25

Bioinformatics In Cancer And Cancer Therapy written by Gavin J. Gordon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-25 with Medical categories.


Bioinformatics can be loosely defined as the collection, classification, storage, and analysis of biochemical and biological information using computers and mathematical algorithms. Bioinformatics represents a marriage of biology, medicine, computer science, physics, and mathematics, fields of study that have historically existed as mutually exclusive disciplines. Edited by Gavin Gordon, Bioinformatics in Cancer and Cancer Therapy, the focus of this book is to provide a historical and technical perspective on the analytical techniques, methodologies, and platforms used in bioinformatics experiments, to show how a bioinformatics approach has been used to characterize various cancer-related processes, and to demonstrate how a bioinformatics approach is being used to bridge basic science and the clinical arena to positively impact patient care and management.



The Charnolosome As A Novel Nanothereranostic Biomarker


The Charnolosome As A Novel Nanothereranostic Biomarker
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Author : Sushil Sharma
language : en
Publisher: Elsevier
Release Date : 2024-09-30

The Charnolosome As A Novel Nanothereranostic Biomarker written by Sushil Sharma and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-30 with Science categories.


The Charnolosome as a Novel Nanothereranostic Biomarker: Overcoming Future Challenges in Medicine provides an overview of the charnolosome and its potential as a biomarker of cell injury. Based on the author's original discovery of the charnoly body in the developing, undernourished rat cerebellar Purkinje neurons, this book delves into the potential for utilizing this mitochondria and lysosomal-derived intracellular organelle as a nanotheranostic biomarker to prevent and cure various diseases.The book discusses the cellular, molecular, genetic, and epigenetic mechanisms of charnolosomes and charnolosome-derived nano-vesicles. It also investigates the molecular mechanisms underlying auto-inflammatory, autoimmune, and infectious diseases resulting from their compromised mitochondrial bioenergetics, and the potential use of the charnolosome in preventing and curing such conditions. - Shares the latest knowledge on the charnolosome and charnolosome-derived nano-vesicles and their significance at a cellular and molecular level - Considers the charnolosome in relation to a range of conditions, including neurodegenerative, metabolic, and multi-drug resistant systemic diseases - Presents future perspectives of the charnolosome in personalized nanotheranostics