Computer Aided Design Of Microfluidic Very Large Scale Integration Mvlsi Biochips
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Computer Aided Design Of Microfluidic Very Large Scale Integration Mvlsi Biochips
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Author : Kai Hu
language : en
Publisher: Springer
Release Date : 2017-04-05
Computer Aided Design Of Microfluidic Very Large Scale Integration Mvlsi Biochips written by Kai Hu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-05 with Technology & Engineering categories.
This book provides a comprehensive overview of flow-based, microfluidic VLSI. The authors describe and solve in a comprehensive and holistic manner practical challenges such as control synthesis, wash optimization, design for testability, and diagnosis of modern flow-based microfluidic biochips. They introduce practical solutions, based on rigorous optimization and formal models. The technical contributions presented in this book will not only shorten the product development cycle, but also accelerate the adoption and further development of modern flow-based microfluidic biochips, by facilitating the full exploitation of design complexities that are possible with current fabrication techniques.
Microfluidic Very Large Scale Integration Vlsi
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Author : Paul Pop
language : en
Publisher: Springer
Release Date : 2016-02-08
Microfluidic Very Large Scale Integration Vlsi written by Paul Pop and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-08 with Technology & Engineering categories.
This book presents the state-of-the-art techniques for the modeling, simulation, testing, compilation and physical synthesis of mVLSI biochips. The authors describe a top-down modeling and synthesis methodology for the mVLSI biochips, inspired by microelectronics VLSI methodologies. They introduce a modeling framework for the components and the biochip architecture, and a high-level microfluidic protocol language. Coverage includes a topology graph-based model for the biochip architecture, and a sequencing graph to model for biochemical application, showing how the application model can be obtained from the protocol language. The techniques described facilitate programmability and automation, enabling developers in the emerging, large biochip market.
Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms
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Author : Mohamed Ibrahim
language : en
Publisher: CRC Press
Release Date : 2020-05-31
Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms written by Mohamed Ibrahim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-31 with Technology & Engineering categories.
A microfluidic biochip is an engineered fluidic device that controls the flow of analytes, thereby enabling a variety of useful applications. According to recent studies, the fields that are best set to benefit from the microfluidics technology, also known as lab-on-chip technology, include forensic identification, clinical chemistry, point-of-care (PoC) diagnostics, and drug discovery. The growth in such fields has significantly amplified the impact of microfluidics technology, whose market value is forecast to grow from $4 billion in 2017 to $13.2 billion by 2023. The rapid evolution of lab-on-chip technologies opens up opportunities for new biological or chemical science areas that can be directly facilitated by sensor-based microfluidics control. For example, the digital microfluidics-based ePlex system from GenMarkDx enables automated disease diagnosis and can bring syndromic testing near patients everywhere. However, as the applications of molecular biology grow, the adoption of microfluidics in many applications has not grown at the same pace, despite the concerted effort of microfluidic systems engineers. Recent studies suggest that state-of-the-art design techniques for microfluidics have two major drawbacks that need to be addressed appropriately: (1) current lab-on-chip systems were only optimized as auxiliary components and are only suitable for sample-limited analyses; therefore, their capabilities may not cope with the requirements of contemporary molecular biology applications; (2) the integrity of these automated lab-on-chip systems and their biochemical operations are still an open question since no protection schemes were developed against adversarial contamination or result-manipulation attacks. Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms provides solutions to these challenges by introducing a new design flow based on the realistic modeling of contemporary molecular biology protocols. It also presents a microfluidic security flow that provides a high-level of confidence in the integrity of such protocols. In summary, this book creates a new research field as it bridges the technical skills gap between microfluidic systems and molecular biology protocols but it is viewed from the perspective of an electronic/systems engineer.
Hardware Software Co Design And Optimization For Cyberphysical Integration In Digital Microfluidic Biochips
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Author : Yan Luo
language : en
Publisher: Springer
Release Date : 2014-08-06
Hardware Software Co Design And Optimization For Cyberphysical Integration In Digital Microfluidic Biochips written by Yan Luo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-06 with Technology & Engineering categories.
This book describes a comprehensive framework for hardware/software co-design, optimization, and use of robust, low-cost, and cyberphysical digital microfluidic systems. Readers with a background in electronic design automation will find this book to be a valuable reference for leveraging conventional VLSI CAD techniques for emerging technologies, e.g., biochips or bioMEMS. Readers from the circuit/system design community will benefit from methods presented to extend design and testing techniques from microelectronics to mixed-technology microsystems. For readers from the microfluidics domain, this book presents a new design and development strategy for cyberphysical microfluidics-based biochips suitable for large-scale bioassay applications. • Takes a transformative, “cyberphysical” approach towards achieving closed-loop and sensor feedback-driven biochip operation under program control; • Presents a “physically-aware” system reconfiguration technique that uses sensor data at intermediate checkpoints to dynamically reconfigure biochips; • Enables readers to simplify the structure of biochips, while facilitating the “general-purpose” use of digital microfluidic biochips for a wider range of applications.
Design Automation Methods And Tools For Microfluidics Based Biochips
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Author : Jun Zeng
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-11-08
Design Automation Methods And Tools For Microfluidics Based Biochips written by Jun Zeng and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-08 with Technology & Engineering categories.
Design Automation Methods and Tools for Microfluidics-Based Biochips deals with all aspects of design automation for microfluidics-based biochips. Experts have contributed chapters on many aspects of biochip design automation. Topics covered include: device modeling; adaptation of bioassays for on-chip implementations; numerical methods and simulation tools; architectural synthesis, scheduling and binding of assay operations; physical design and module placement; fault modeling and testing; and reconfiguration methods.
Design And Testing Of Digital Microfluidic Biochips
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Author : Yang Zhao
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-25
Design And Testing Of Digital Microfluidic Biochips written by Yang Zhao and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-25 with Technology & Engineering categories.
This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.
Digital Microfluidic Biochips
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Author : Krishnendu Chakrabarty
language : en
Publisher: CRC Press
Release Date : 2010-05-03
Digital Microfluidic Biochips written by Krishnendu Chakrabarty and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-03 with Medical categories.
Microfluidics-based biochips combine electronics with biochemistry, providing access to new application areas in a wide variety of fields. Continued technological innovations are essential to assuring the future role of these chips in functional diversification in biotech, pharmaceuticals, and other industries.Revolutionary guidance on design, opti
Design Automation For Digital Microfluidic Biochips
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Author : Tsung-Yi Ho
language : en
Publisher: CRC Press
Release Date : 2016-02-15
Design Automation For Digital Microfluidic Biochips written by Tsung-Yi Ho and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-15 with Technology & Engineering categories.
This book demonstrates the use of computer-aided design (CAD) tools to automate and optimize the design and synthesis of digital microfluidicbiochips (DMFBs) in fluidic and chip/hardware domains. It describes several associative combinatorial and geometric optimization problems; considers new constraints in low-cost, large-scale biochip design; and includes real-life bioassays as evaluation examples (e.g., DNA sample preparation, multiplexed in-vitro human physiological fluids diagnostics, PCR, and protein crystallization). The CAD techniques presented address real manufacturing issues and can be applied directly to industrial product development.
Digital Microfluidic Biochips
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Author : Krishnendu Chakrabarty
language : en
Publisher: CRC Press
Release Date : 2018-10-03
Digital Microfluidic Biochips written by Krishnendu Chakrabarty and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-03 with Technology & Engineering categories.
Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips. Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.
Design And Testing Of Digital Microfluidic Biochips
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Author : Krishnendu Chakrabarty
language : en
Publisher:
Release Date : 2012-08-31
Design And Testing Of Digital Microfluidic Biochips written by Krishnendu Chakrabarty and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-31 with categories.
This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.