Concepts And Misconceptions Of Drug Targeting
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Concepts And Misconceptions Of Drug Targeting
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Author : Karel Petrak
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2020-08-05
Concepts And Misconceptions Of Drug Targeting written by Karel Petrak and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-05 with Medical categories.
Precision medicine requires precision drugs that match the needs of individual patients. An ideal drug, popularly referred to as the “magic bullet”, should be effective without causing any unwanted side effects. To do this, drugs must act solely on the target of the disease. Despite major efforts in this area over some 50 years, the currently available drugs are far from being “idea”. This book summarizes the key requirements for developing precision drugs and offers a new paradigm for site-specific drug delivery. As such, it will be of interest to personnel involved in drug development at pharmaceutical and biotech companies and academic institutions.
Ending Discrimination Against People With Mental And Substance Use Disorders
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-09-03
Ending Discrimination Against People With Mental And Substance Use Disorders written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-03 with Social Science categories.
Estimates indicate that as many as 1 in 4 Americans will experience a mental health problem or will misuse alcohol or drugs in their lifetimes. These disorders are among the most highly stigmatized health conditions in the United States, and they remain barriers to full participation in society in areas as basic as education, housing, and employment. Improving the lives of people with mental health and substance abuse disorders has been a priority in the United States for more than 50 years. The Community Mental Health Act of 1963 is considered a major turning point in America's efforts to improve behavioral healthcare. It ushered in an era of optimism and hope and laid the groundwork for the consumer movement and new models of recovery. The consumer movement gave voice to people with mental and substance use disorders and brought their perspectives and experience into national discussions about mental health. However over the same 50-year period, positive change in American public attitudes and beliefs about mental and substance use disorders has lagged behind these advances. Stigma is a complex social phenomenon based on a relationship between an attribute and a stereotype that assigns undesirable labels, qualities, and behaviors to a person with that attribute. Labeled individuals are then socially devalued, which leads to inequality and discrimination. This report contributes to national efforts to understand and change attitudes, beliefs and behaviors that can lead to stigma and discrimination. Changing stigma in a lasting way will require coordinated efforts, which are based on the best possible evidence, supported at the national level with multiyear funding, and planned and implemented by an effective coalition of representative stakeholders. Ending Discrimination Against People with Mental and Substance Use Disorders: The Evidence for Stigma Change explores stigma and discrimination faced by individuals with mental or substance use disorders and recommends effective strategies for reducing stigma and encouraging people to seek treatment and other supportive services. It offers a set of conclusions and recommendations about successful stigma change strategies and the research needed to inform and evaluate these efforts in the United States.
Blood Brain Barrier In Drug Discovery
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Author : Li Di
language : en
Publisher: John Wiley & Sons
Release Date : 2015-02-02
Blood Brain Barrier In Drug Discovery written by Li Di and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-02 with Medical categories.
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
Fundamental Concepts
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Author : Fidele Ntie-Kang
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2020-02-24
Fundamental Concepts written by Fidele Ntie-Kang and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-24 with Science categories.
Vol. 1 of Chemoinformatics of Natural Products presents an overview of natural products chemistry, discussing the chemical space of naturally occurring compounds, followed by an overview of computational methods.
Assessing Bioavailablility Of Drug Delivery Systems
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Author : Jean-Maurice Vergnaud
language : en
Publisher: CRC Press
Release Date : 2005-05-26
Assessing Bioavailablility Of Drug Delivery Systems written by Jean-Maurice Vergnaud and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-26 with Medical categories.
Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, Bioavailability of Drug Delivery Systems: Mathematical Modeling clearly elucidates this complex phenomena and provides a guide for the respective mathematical modeling. The book introduces mathematical modeling methods for calculating the profiles of plasma le
Drugs Brains And Behavior
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Author :
language : en
Publisher:
Release Date : 2007
Drugs Brains And Behavior written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Brain categories.
Drug Delivery
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Author : Yitzhak Rosen
language : en
Publisher: CRC Press
Release Date : 2017-09-19
Drug Delivery written by Yitzhak Rosen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-19 with Medical categories.
Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.
Drug Delivery To The Brain
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Author : Margareta Hammarlund-Udenaes
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-03
Drug Delivery To The Brain written by Margareta Hammarlund-Udenaes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-03 with Medical categories.
The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.
Comprehensive Medicinal Chemistry Iii
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Author :
language : en
Publisher: Elsevier
Release Date : 2017-06-03
Comprehensive Medicinal Chemistry Iii written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-03 with Technology & Engineering categories.
Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
Concepts And Principles Of Pharmacology
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Author : James E. Barrett
language : en
Publisher: Springer Nature
Release Date : 2019-12-24
Concepts And Principles Of Pharmacology written by James E. Barrett and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-24 with Medical categories.
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.