Contributions To Statistical Analysis Of Gene Expression Data
DOWNLOAD
Download Contributions To Statistical Analysis Of Gene Expression Data PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Contributions To Statistical Analysis Of Gene Expression Data book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Contributions To Statistical Analysis Of Gene Expression Data
DOWNLOAD
Author : Anders Sjögren
language : en
Publisher:
Release Date : 2005
Contributions To Statistical Analysis Of Gene Expression Data written by Anders Sjögren and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Reassessing The Immune System Contribution In Multiple Sclerosis Therapeutic Target Biomarkers Of Disease And Immune Pathogenesis
DOWNLOAD
Author : Maria Teresa Cencioni
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-10
Reassessing The Immune System Contribution In Multiple Sclerosis Therapeutic Target Biomarkers Of Disease And Immune Pathogenesis written by Maria Teresa Cencioni and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-10 with Medical categories.
Cancer Cell Reprogramming Impact On Carcinogenesis And Cancer Progression
DOWNLOAD
Author : Ira Ida Skvortsova
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-24
Cancer Cell Reprogramming Impact On Carcinogenesis And Cancer Progression written by Ira Ida Skvortsova and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-24 with Science categories.
Amstat News
DOWNLOAD
Author : American Statistical Association
language : en
Publisher:
Release Date : 2002
Amstat News written by American Statistical Association and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Statistics categories.
Tailoring Nk Cell Receptor Ligand Interactions An Art In Evolution 2nd Edition
DOWNLOAD
Author : Ulrike Koehl
language : en
Publisher: Frontiers Media SA
Release Date : 2018-11-13
Tailoring Nk Cell Receptor Ligand Interactions An Art In Evolution 2nd Edition written by Ulrike Koehl and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-13 with Immunologic diseases. Allergy categories.
Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the understanding of NK cell biology, these studies are critical for effective translation of NK-based immunotherapy principles into the clinic. In humans, dominant inhibitory signals are transduced by Killer Immunoglobulin Like Receptors (KIR) recognizing cognate HLA class I on target cells. Conversely, KIR recognition of “missing self-HLA” - due to HLA loss or HLA/ KIR mismatch - triggers NK-mediated tumor rejection. Initially observed in murine transplant models, these antitumor effects were later found to have important implications for the clinical outcome of haplotype-mismatched stemcell transplantation. Here, donor NK subsets protect against acute myeloid leukemia (AML) relapse through missing self recognition of donor HLA-C allele groups (C1 or C2) and/or Bw4 epitope. These studies were subsequently extended by trials investigating the antileukemia effects of adoptively transferred haplotype-mismatched NK cells in non-transplant settings. Other mechanisms have been found to induce clinically relevant NK cell alloreactivity in transplantation, e.g., post-reconstitution functional reversal of anergic NK cells. More recently, activating KIR came into the spotlight for their potential ability to directly activate donor NK cells through in vivo recognition of HLA or other ligands. Novel therapeutic monoclonal antibodies (mAb) may optimize NK-mediated effects. Examples include obinutuzumab (GA101), a glyco-engineered anti-CD20 mAb with increased affinity for the FcγRIIIA receptor, enhancing antibody-dependent cellular cytotoxicity; lirilumab (IPH2102), a first-in-class NK-specific checkpoint inhibitor, blocking the interaction between the major KIR and cognate HLA-C antigens; and elotuzumab (HuLuc63), a humanized monoclonal antibody specific for SLAMF7, whose anti-myeloma therapeutic effects are partly due to direct activation of SLAMF7-expressing NK cells. In addition to conventional antibodies, NK cell-targeted bispecific (BiKEs) and trispecific (TriKEs) killer engagers have also been developed. These proteins elicit potent effector functions by binding target ligands (e.g., CD19, CD22, CD30, CD133, HLA class II, EGFR) on one arm and NK receptors on the other. An additional innovative approach to direct NK cell activity is genetic reprogramming with chimeric antigen receptors (CAR). To date, primary NK cells and the NK92 cell line have been engineered with CAR specific for antigens expressed on multiple tumors. Encouraging preclinical results warrant further development of this approach. This Research Topic welcomes contributions addressing mechanisms of NK-mediated activation in response to disease as well as past and contemporary strategies to enhance NK mediated reactivity through control of the interactions between NK receptors and their ligands.
Phenomics
DOWNLOAD
Author : Roberto Fritsche-Neto
language : en
Publisher: Springer
Release Date : 2015-01-13
Phenomics written by Roberto Fritsche-Neto and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-13 with Science categories.
This book represents a pioneer initiative to describe the new technologies available for next-generation phenotyping and applied to plant breeding. Over the last several years plant breeding has experienced a true revolution. Phenomics, i.e., high-throughput phenotyping using automation, robotics and remote data collection, is changing the way cultivars are developed. Written in an easy to understand style, this book offers an indispensable reference work for all students, instructors and scientists who are interested in the latest innovative technologies applied to plant breeding.
Cancer Bioinformatics
DOWNLOAD
Author : Ying Xu
language : en
Publisher: Springer
Release Date : 2014-08-30
Cancer Bioinformatics written by Ying Xu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-30 with Computers categories.
This book provides a framework for computational researchers studying the basics of cancer through comparative analyses of omic data. It discusses how key cancer pathways can be analyzed and discovered to derive new insights into the disease and identifies diagnostic and prognostic markers for cancer. Chapters explain the basic cancer biology and how cancer develops, including the many potential survival routes. The examination of gene-expression patterns uncovers commonalities across multiple cancers and specific characteristics of individual cancer types. The authors also treat cancer as an evolving complex system, explore future case studies, and summarize the essential online data sources. Cancer Bioinformatics is designed for practitioners and researchers working in cancer research and bioinformatics. It is also suitable as a secondary textbook for advanced-level students studying computer science, biostatistics or biomedicine.
Advances In Genetic And Epigenetic Mechanisms Of Therapeutic Resistance In Cancer
DOWNLOAD
Author : Yilin Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-03
Advances In Genetic And Epigenetic Mechanisms Of Therapeutic Resistance In Cancer written by Yilin Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-03 with Science categories.
Molecular Mechanisms Of Dendritic Cell Mediated Immune Tolerance And Autoimmunity
DOWNLOAD
Author : Fang Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-09
Molecular Mechanisms Of Dendritic Cell Mediated Immune Tolerance And Autoimmunity written by Fang Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-09 with Medical categories.
Dendritic cells (DCs) play a critical role in immune system, as they are necessary both for innate and adaptive immunity. According to their function, dendritic cells can be classified in immune tolerogenic or inflammatory DCs. DCs have been shown to regulate T cell-mediated immune responses and lead to immune tolerance and autoimmunity. For example, immune-tolerogenic DCs facilitate the development of regulatory T cells and inhibit T helper 17-mediated autoimmunity in mice with experimental autoimmune encephalomyelitis. Moreover, inflammatory DCs activate CD8+ and CD4+ T cells and elicit T cell-mediated inflammatory immune responses in vivo. However, the molecular and cellular mechanisms underlying DC-mediated immune tolerance and autoimmunity are still obscure.
Germinal Centers In Lymphoid And Non Lymphoid Tissues Adaptive And Evolving Structures
DOWNLOAD
Author : Said Aoufouchi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-18
Germinal Centers In Lymphoid And Non Lymphoid Tissues Adaptive And Evolving Structures written by Said Aoufouchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-18 with Medical categories.