Crossover Designs
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Optimal Crossover Designs
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Author : Mausumi Bose
language : en
Publisher: World Scientific
Release Date : 2009
Optimal Crossover Designs written by Mausumi Bose and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Mathematics categories.
This monograph presents a comprehensive and up-to-date account of the developments in optimality aspects of crossover designs. Crossover designs are immensely useful in various areas of human investigation including agriculture, animal nutrition, clinical trials, pharmaceutical studies, biological assays, weather modification experiments, sensory evaluation of food products and learning experiments. Research on the optimality aspects of crossover designs has developed only in the last three decades, and it has now emerged as a potential field for further investigation. This book is the first comprehensive treatise on this subject. It covers optimal crossover designs at length by consolidating vast amounts of material from the literature, and includes many recent and deep results. It is expected that this book will not only provide a one-stop reference for the available results, but also encourage further research in this area of substantial practical relevance.
Crossover Designs
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Author : Kung-Jong Lui
language : en
Publisher: John Wiley & Sons
Release Date : 2016-09-26
Crossover Designs written by Kung-Jong Lui and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-26 with Medical categories.
A comprehensive and practical resource for analyses of crossover designs For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible. As evidenced by extensive research publications, crossover design can be a useful and powerful tool to reduce the number of patients needed for a parallel group design in studying treatments for non-curable chronic diseases. This book introduces commonly-used and well-established statistical tests and estimators in epidemiology that can easily be applied to hypothesis testing and estimation of the relative treatment effect for various types of data scale in crossover designs. Models with distribution-free random effects are assumed and hence most approaches considered here are semi-parametric. The book provides clinicians and biostatisticians with the exact test procedures and exact interval estimators, which are applicable even when the number of patients in a crossover trial is small. Systematic discussion on sample size determination is also included, which will be a valuable resource for researchers involved in crossover trial design. Key features: Provides exact test procedures and interval estimators, which are especially of use in small-sample cases. Presents most test procedures and interval estimators in closed-forms, enabling readers to calculate them by use of a pocket calculator or commonly-used statistical packages. Each chapter is self-contained, allowing the book to be used a reference resource. Uses real-life examples to illustrate the practical use of test procedures and estimators Provides extensive exercises to help readers appreciate the underlying theory, learn other relevant test procedures and understand how to calculate the required sample size. Crossover Designs: Testing, Estimation and Sample Size will be a useful resource for researchers from biostatistics, as well as pharmaceutical and clinical sciences. It can also be used as a textbook or reference for graduate students studying clinical experiments.
Optimal Crossover Designs
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Author : Aloke Dey
language : en
Publisher: World Scientific
Release Date : 2009
Optimal Crossover Designs written by Aloke Dey and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Science categories.
This monograph presents a comprehensive and up-to-date account of the developments in optimality aspects of crossover designs. Crossover designs are immensely useful in various areas of human investigation including agriculture, animal nutrition, clinical trials, pharmaceutical studies, biological assays, weather modification experiments, sensory evaluation of food products and learning experiments. Research on the optimality aspects of crossover designs has developed only in the last three decades, and it has now emerged as a potential field for further investigation. This book is the first comprehensive treatise on this subject. It covers optimal crossover designs at length by consolidating vast amounts of material from the literature, and includes many recent and deep results. It is expected that this book will not only provide a one-stop reference for the available results, but also encourage further research in this area of substantial practical relevance.
Crossover Designs
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Author : Kung-Jong Lui
language : en
Publisher: John Wiley & Sons
Release Date : 2016-08-08
Crossover Designs written by Kung-Jong Lui and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-08 with Medical categories.
A comprehensive and practical resource for analyses of crossover designs For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible. As evidenced by extensive research publications, crossover design can be a useful and powerful tool to reduce the number of patients needed for a parallel group design in studying treatments for non-curable chronic diseases. This book introduces commonly-used and well-established statistical tests and estimators in epidemiology that can easily be applied to hypothesis testing and estimation of the relative treatment effect for various types of data scale in crossover designs. Models with distribution-free random effects are assumed and hence most approaches considered here are semi-parametric. The book provides clinicians and biostatisticians with the exact test procedures and exact interval estimators, which are applicable even when the number of patients in a crossover trial is small. Systematic discussion on sample size determination is also included, which will be a valuable resource for researchers involved in crossover trial design. Key features: Provides exact test procedures and interval estimators, which are especially of use in small-sample cases. Presents most test procedures and interval estimators in closed-forms, enabling readers to calculate them by use of a pocket calculator or commonly-used statistical packages. Each chapter is self-contained, allowing the book to be used a reference resource. Uses real-life examples to illustrate the practical use of test procedures and estimators Provides extensive exercises to help readers appreciate the underlying theory, learn other relevant test procedures and understand how to calculate the required sample size. Crossover Designs: Testing, Estimation and Sample Size will be a useful resource for researchers from biostatistics, as well as pharmaceutical and clinical sciences. It can also be used as a textbook or reference for graduate students studying clinical experiments.
The Design Of Active Crossovers
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Author : Douglas Self
language : en
Publisher: Routledge
Release Date : 2018-03-28
The Design Of Active Crossovers written by Douglas Self and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-28 with Technology & Engineering categories.
Active crossovers are used by almost every sound reinforcement system and every recording studio monitoring set-up; but the use of active crossovers is rapidly expanding. This new edition, presents all the updates to loudspeaker technology and crossover design. The edition expands on loudspeaker configurations and design issues, sound reinforcement issues, more on lowpass and highpass filters, and may other filters. This new edition is a must read for anyone wanting comprehensive practical knowledge.
Optimal Crossover Designs With Interactions Between Treatments And Units
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Author : Andrea M. Bludowsky
language : en
Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
Release Date : 2009-12
Optimal Crossover Designs With Interactions Between Treatments And Units written by Andrea M. Bludowsky and has been published by Sudwestdeutscher Verlag Fur Hochschulschriften AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12 with categories.
Many papers deal with the most common model for crossover designs, which typically include period, unit, direct treatment, and carryover effects. However, some authors argue the common model to be too simple in its assumptions and suggest that unit by treatment interaction may be of additional importance. Therefore, the interest of this doctoral thesis is to find optimal crossover designs in an unconstrained model with random assessor effects. The observations are assumed to be influenced by carryover effects and additional interactions between treatments and units. Kushner's method is applied in order to evaluate how interaction and carryover effects operate conjointly in an optimal crossover design. The method by Kushner maximizes the trace of the information matrix of the design on the basis of design-dependent equivalence class functions. There are three equivalence classes of treatment sequences, which are crucial for the generation of an approximated optimal design if the number of periods does not exceed six.
On The Theory Of Crossover Designs With Residual Effects
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Author : Ronald Paul Kershner
language : en
Publisher:
Release Date : 1980
On The Theory Of Crossover Designs With Residual Effects written by Ronald Paul Kershner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Biomathematics categories.
Clinical Research
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Author : Manfred Stommel
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2004
Clinical Research written by Manfred Stommel and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
This unique textbook integrates statistical concepts into evidence-based clinical practice and patient management. Research concepts and techniques are drawn from epidemiology, bio-statistics, and psychometrics, as well as educational and social science research. Clinical examples throughout the text illustrate practical and scientifically sound applications of the concepts. Data tables and research vignettes highlight statistical distributions involving probability. Methods to locate and utilize web-based information relevant to clinical research are discussed, and web URLs are provided. Further learning is encouraged by the inclusion of suggested activities, recommended readings, references, and a comprehensive glossary of research terms. Additional resources are available at a Connection Website, connection.LWW.com/go/stommel.
Clinical Trials In Neurology
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Author : Bernard Ravina
language : en
Publisher: Cambridge University Press
Release Date : 2012-04-12
Clinical Trials In Neurology written by Bernard Ravina and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-12 with Medical categories.
Comprehensive book that suggests ways to improve the efficiency of clinical trials and the development of interventions in the neurosciences.
Cross Over Trials In Clinical Research
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Author : Stephen S. Senn
language : en
Publisher: John Wiley & Sons
Release Date : 2003-07-25
Cross Over Trials In Clinical Research written by Stephen S. Senn and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-25 with Mathematics categories.
Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages. * Comprehensive coverage of the design and analysis of cross-over trials. * Each technique is carefully explained and the mathematics is kept to a minimum. * Features many real and original examples, taken from the author's vast experience. * Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel. * Written in a style suitable for statisticians and physicians alike. * Computer programs to accompany the examples in the book can be downloaded from the Web Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.