Current And Future Developments In Physiology Control Of Pancreatic Beta Cell Function And Plasticity In Health And Diabetes
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Control Of Pancreatic Beta Cell Function And Plasticity In Health And Diabetes
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Author : David J. Hill
language : en
Publisher: Bentham Science Publishers
Release Date : 2016-12-02
Control Of Pancreatic Beta Cell Function And Plasticity In Health And Diabetes written by David J. Hill and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-02 with Science categories.
Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity: -current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.
Current And Future Developments In Physiology Control Of Pancreatic Beta Cell Function And Plasticity In Health And Diabetes
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Author : David Hill
language : en
Publisher: Current and Future Development
Release Date : 2016-12-02
Current And Future Developments In Physiology Control Of Pancreatic Beta Cell Function And Plasticity In Health And Diabetes written by David Hill and has been published by Current and Future Development this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-02 with Science categories.
Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity: -current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.
Fetal And Early Postnatal Programming And Its Influence On Adult Health
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Author : Mulchand S. Patel
language : en
Publisher: CRC Press
Release Date : 2017-07-12
Fetal And Early Postnatal Programming And Its Influence On Adult Health written by Mulchand S. Patel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-12 with Medical categories.
There is a documented link between fetal nutrition and the development of disease risk in adult life. Including the early postnatal period, during which a newborn continues to grow rapidly influenced by environmental factors, suggests that individuals are subject to risks for more than just the fetal period. Fetal and Early Postnatal Programming and its Influence on Adult Health focuses on interrelated aspects of cellular programming related to early nutrition and this potential global health problem.
Comparative Studies Of Energy Homeostasis In Vertebrates
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Author : Maximilian Michel
language : en
Publisher: Frontiers Media SA
Release Date : 2018-08-03
Comparative Studies Of Energy Homeostasis In Vertebrates written by Maximilian Michel and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-03 with categories.
A brief glimpse into new insight driving the comparative biology of energy homeostasis in vertebrates with a focus on non-mammalian vertebrates. What are the key conserved mechanisms and what aspects of feeding behavior and energy allocation are different between species?
Early Nutrition And Long Term Health
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Author : Jose M Saavedra
language : en
Publisher: Woodhead Publishing
Release Date : 2022-08-06
Early Nutrition And Long Term Health written by Jose M Saavedra and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-06 with Health & Fitness categories.
Early Nutrition and Long-Term Health: Mechanisms, Consequences, and Opportunities, Second Edition updates and expands upon the content in the first edition and adds focus on actionable and modifiable aspects of nutrition that have an impact on long-term health and disease. Part I examines the associations and the mechanisms of early life nutrition on growth as well as the development of cognitive, metabolic, immune, and dietary patterns and behaviors. Part II reviews the associations and impact of early life nutrition on non-communicable disease as well as their societal and economic impact. Part III focuses on the dietary and nutritional needs and approaches to optimizing the different stages of nutrition, from conception to the second year of life. Nutritionists, pediatricians, academics with research interest in this area, and food industry and healthcare professionals working in infant/child product and services, as well as students studying related disciplines, will benefit from this updated reference. - Examines the relation between early life nutrition and long-term health - Reviews the mechanistic aspects of the impact of diet, nutrition, from conception through the first years of life, on health in later life - Details the associations and the impact of early life nutrition on growth and development, cognition, immunity, metabolism, and dietary habits and patterns - Addresses the relationship of early life nutrition and with non-communicable diseases, including allergies, cardiovascular diseases, metabolic conditions, and obesity, as well as approaches to curtail them - Explores the current societal and economic impact and the potential for interventions to improving nutrition and health
Proglucagon Derived Peptides
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Author : Peter Flatt
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-06
Proglucagon Derived Peptides written by Peter Flatt and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-06 with Medical categories.
Carotid Body A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease
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Author : Rodrigo Del Rio
language : en
Publisher: Frontiers Media SA
Release Date : 2016-12-12
Carotid Body A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease written by Rodrigo Del Rio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-12 with Physiology categories.
The carotid body (CB) is in charge of adjusting ventilatory and cardiovascular function during changes in arterial blood gases. Regardless this essential function, the CB has been implicated in the sensing of other physiological signals such as changes in blood flow and glucose levels. More important, malfunction of the CB chemoreceptors has been associated with the progression and deterioration of several disease states such as hypertension, heart failure, renal failure, insulin resistance, diabetes and sleep apnea. Although the mechanisms involved in the alterations of the CB function in pathophysiology are currently under intense research, the development of therapeutic approaches to restore normal CB chemoreflex function remains unsolved. Recent studies showing the effect of CB denervation in pathophysiology have unveiled a key role of these arterial chemoreceptors in the development of autonomic imbalance and respiratory disturbances, and suggest that targeting the CB could represent a novel strategy to improve disease outcome. Unfortunately, classical pharmacotherapy intended to normalize CB function may be hard to establish since several cellular pathways are involved in the CB dysfunction. Augmented levels of angiotensin II, endothelin-1, cytokines and free radicals along with decreases in nitric oxide had all been related to the CB dysfunction. Moreover, changes in expression of angiotensin receptors, nitric oxide synthases and cytokines that take place within the CB tissue in pathological states also contribute to the enhanced CB chemoreflex drive. It has been shown in heart failure, hypertension and obstructive sleep apnea that the CB becomes tonically hyper-reactive. During the progression of the disease this CB chemosensory facilitation process induces central nervous system plasticity. The altered autonomic-respiratory control leads to increased cardiorespiratory distress and the deterioration of the condition. The focus of this e-book will be to cover the role of the CB in pathophysiology and to provide new evidence of the pathways involved in the maladaptive potentiation of the CB chemoreflex function. In memory of Professor Mashiko Shirahata and Professor Constancio Gonzalez.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1978
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Medicine categories.
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Research Grants Index
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Author : National Institutes of Health (U.S.). Division of Research Grants
language : en
Publisher:
Release Date : 1973
Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Medicine categories.