Cyclic Nucleotides Phosphorylated Proteins And Neuronal Function
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Cyclic Nucleotides Phosphorylated Proteins And Neuronal Function
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Author : Paul Greengard
language : en
Publisher:
Release Date : 1978
Cyclic Nucleotides Phosphorylated Proteins And Neuronal Function written by Paul Greengard and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Medical categories.
Modulators Mediators And Specifiers In Brain Function
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Author : Y. H. Erlich
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Modulators Mediators And Specifiers In Brain Function written by Y. H. Erlich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
While neuroanatomy and neurophysiology were defining the unique features of the synapse as a site for cell to cell signaling in the late fifties, neurochemistry was establishing the identity and studying the biosynthetic pathways of monoamine neurotransmitters. Meanwhile, neuropsychiatry was keeping a vigilant eye on the outcome of this concerted effort with the untold hope that a genetic defect in neurotransmitter metabolism would ac count for the pathogenesis of certain psychiatric ill nesses. Thus, when neurochemists in the early sixties began to study the feasibility of measuring the metabolism of brain neurotransmitters in vivo, clinical biochemists eagerly adopted these methods to their needs and sought to verify whether inborn errors of transmitter biogenesis were a cause for at least certain forms of depression, mania and schizophrenia. Undoubtedly, it is still too early to evaluate the outcome of these studies. However, current opinion holds that gross inborn errors in transmitter metabolism do not anpear to be operative as a primary cause of psychia tric disorders. Though monoamine metabolism appears to be defective in certain groups of psychiatric disorders, the cause of these changes can at best be associated with changes in patterns of neuronal firing. It is generally believed that these persistent changes are determined by a number of unknown factors operative in various psychia tric illnesses. In the attempt to identify the molecular nature of these unknown factors, the focus of current research is directed toward transmitter receptors.
Protein Phosphorylation In The Nervous System
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Author : Eric J. Nestler
language : en
Publisher:
Release Date : 1984-06-14
Protein Phosphorylation In The Nervous System written by Eric J. Nestler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984-06-14 with Medical categories.
Considers the role of protein phosphorylation in neuron-specific phenomena. Comprehensively treats the enzymes and molecular biology of phosphorylation and dephosphorylation reactions, examines evidence for the obligatory role of these reactions in neuronal function, and extensively reviews the large number of phosphorylation pathways and their interactions. Original schematic diagrams illustrate principles of the biochemical basis of cell regulation.
Model Systems In Signal Transduction
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Author : Shirish Shenolikar
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1993
Model Systems In Signal Transduction written by Shirish Shenolikar and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Cell interaction categories.
In this volume, distinguished investigators discuss their research on intracellular signal transduction in microorganisms. The findings presented aim to shed new light on fundamental processes of cell regulation in complex as well as simple organisms.
Biochemistry Of Smooth Muscle Contraction
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Author : Michael Barany
language : en
Publisher: Elsevier
Release Date : 1996-01-04
Biochemistry Of Smooth Muscle Contraction written by Michael Barany and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-04 with Science categories.
This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.
Cyclic Nucleotides
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Author : P. D. Kebabian
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cyclic Nucleotides written by P. D. Kebabian and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cyclic nucleotides are intimately involved in the consequences of either stimulation or blockade of receptors; therefore, an understanding of the biochemistry of cyclic nucleotides ought to be important for pharmacologists. Pharmacology is a science that among other things investigates chemical compounds that affect the physiology of cells, tissues and organs. Frequently pharmacologists account for the effect of low concentrations of a drug upon a tissue by invoking the presence of a receptor upon the surface of the cell. Traditional pharmacologists excelled at identifying and classifying the properties of receptors. A. J. CLARK'S monograph in the earlier series of the Handbook of Experimental Pharmacology (CLARK 1937) summarized the mathematics underlying the traditional pharmacological approach towards receptors. By its nature, however, classic pharmacology provided little useful information about the intracellular events occurring as a consequence of occupying a receptor; for example, ALQUIST (1948) identified the beta-adrenocep tor, but he did not provide any insight into how stimulation of the receptor produces tissue-specific physiological responses. The discovery of cyclic AMP by RALL and SUTHERLAND (see RALL, Vol. I) led to biochemical investigations of many different receptors (including ALQUIST'S beta-adrenoceptor) that share a cyclic nucleotide as a common factor in the biochemical mechanisms that translate the occupancy of receptors into physiological effects. Ten years ago, in the introduction to their monograph on cyclic nucleotides, ROBISON et al. (1971) commented on the rapid growth of interest in cyclic nucleotides over the preceding years.
Cyclic Nucleotides
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Author : J. A. Nathanson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cyclic Nucleotides written by J. A. Nathanson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators. Each of the chapters is the work of internationally known researchers who present a lucid and detailed review of their subject and not merely a single laboratory's viewpoint. The chapters emphasize critical assessments of the field rather than mere listings of experimental findings. By so doing, the contributors present the role of cyclic nucleotides in relationship to other intracellular regulators. Each chapter begins with a detailed summary to allow the reader to obtain a rapid overview of subsequent material. In addition, there are extensive bibliographies and a detailed subject index. Wherever pertinent, the chapters contain sections on drug mechanisms, physiological relevance, and disease processes. The Volume is divided into two sections, each beginning with an overview written by Professors T. W. RALL and P. GREENGARD, respectively. The first section focuses on the detailed pharmacology and chemistry of cyclic nucleotides, including their formation, degradation, measurement, and interaction with various modulatory agents, such as receptors and calcium. The second section is concerned with the biochemistry of protein phosphorylation, a process which appears to be one of the most important mechanisms for the intracellular expression of cyclic nucleotide action in eukaryotic cells.
Molecular Aspects Of Bioelectricity
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Author : Ernest Schoffeniels
language : en
Publisher: Elsevier
Release Date : 2014-04-24
Molecular Aspects Of Bioelectricity written by Ernest Schoffeniels and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-24 with Nature categories.
Molecular Aspects of Bioelectricity describes the self-organization in molecular and cellular networks. This book evaluates the chemical representation of ion flux gating in excitable biomembranes and addresses the theoretical implication of liganding reactions in axonal sodium channel gating. It also strongly demonstrates the ligand interactions of crustacean axonal membrane. The opening chapters deal with the biochemical studies of the structure, mechanism, and differentiation of the voltage-sensitive sodium channel; and biochemical cycle of impedance variation in axonal membranes. The succeeding chapters examine the effect of various compounds on the phosphorylation of nerve proteins and the molecular aspects of the actions of cyclic nucleotides at synapses. These topics are followed by discussions of the acetylcholine and choline acetyltransferase, as well as the polymorphism of cholinesterase in vertebrates. The closing chapters are devoted to the physical factors determining gated flux from and into sealed membrane fragments. The book can provide useful information to biologists, students, and researchers.
Molecular Mechanisms Of Neuronal Responsiveness
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Author : Yigal H. Ehrlich
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Molecular Mechanisms Of Neuronal Responsiveness written by Yigal H. Ehrlich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Science categories.
The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.
Bibliography Of Medical Reviews
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Author :
language : en
Publisher:
Release Date : 1976
Bibliography Of Medical Reviews written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Medical literature categories.