Protein Phosphorylation In The Nervous System
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Protein Phosphorylation In The Nervous System
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Author : Eric J. Nestler
language : en
Publisher:
Release Date : 1984-06-14
Protein Phosphorylation In The Nervous System written by Eric J. Nestler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984-06-14 with Medical categories.
Considers the role of protein phosphorylation in neuron-specific phenomena. Comprehensively treats the enzymes and molecular biology of phosphorylation and dephosphorylation reactions, examines evidence for the obligatory role of these reactions in neuronal function, and extensively reviews the large number of phosphorylation pathways and their interactions. Original schematic diagrams illustrate principles of the biochemical basis of cell regulation.
Kinases And Phosphatases In Lymphocyte And Neuronal Signaling
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Author : Hidetaka Yakura
language : en
Publisher: Springer
Release Date : 1997-09-22
Kinases And Phosphatases In Lymphocyte And Neuronal Signaling written by Hidetaka Yakura and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-09-22 with Science categories.
Almost every aspect of cell function is controlled by protein phosphorylation, a reversible process tightly regulated by protein kinases and protein phosphatases, and the immune and the nervous systems are no exceptions. This book deals, for the first time, with these two highly sophisticated systems from the perspectives of both protein kinases and phosphatases. In the first part, general mechanisms of protein phosphorylation and the structural basis of tyrosine phosphatases are discussed. The second part describes the physiology and pathology of signal transduction of T and B lymphocytes, primarily via antigen receptors. In the last section, signal transduction in the neuronal system is considered.
Brain Signal Transduction And Memory
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Author : Masao Ito
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Brain Signal Transduction And Memory written by Masao Ito and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Self-Help categories.
Brain Signal Transduction and Memory is a compilation of the proceedings of the Fifth Takeda Science Foundation Symposium on Bioscience, held on November 28-30, 1988, in Kyoto, Japan. The symposium provided a forum for the discussion of a wide range of topics on brain signal transduction and its role in memory formation. Topics covered include the role of phosphoinositides in neural signaling; the homeostasis of calcium ions; the involvement of protein kinase C in brain signal transduction and memory formation; long-term potentiation in the hippocampus; synaptic plasticity and memory; and organization of neural tissues by plasticity. This book is comprised of 21 chapters and begins with an analysis of the phosphoinositide signaling system and how it might function within the nervous system, followed by a discussion on the molecular heterogeneity of the protein kinase C family and its implications for the regulation of neuronal cells. The formation and reorganization of synaptic contacts in the developing nervous system, as well as the factors that influence the plasticity of this process, are then explored. Other chapters focus on the biochemical mechanisms involved in the generation and maintenance of enhanced synaptic transmission; quantal release in the hippocampus; molecular mechanisms of long-term depression in the cerebellum; and cellular mechanisms for reorganization of synaptic inputs after early brain damage. This monograph will appeal to biologists, physiologists, bioscientists, and clinicians.
Gene Expression In The Central Nervous System
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Author : A.C.H. Yu
language : en
Publisher: Elsevier
Release Date : 1995-08-01
Gene Expression In The Central Nervous System written by A.C.H. Yu and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-08-01 with Science categories.
Gene expression is an active ongoing process that maintains a functional CNS, as proteins are being made on a continual basis. Processes such as learning and memory, nerve cell repair and regeneration and its response to stress are critically dependent on gene expression. This volume highlights the role of gene expression in normal CNS function, and presents many research methods at the cutting edge of neuroscience, which will provide insight into therapeutic approaches through which the control of gene expression may be used in the treatment of many nervous system diseases.
Cyclic Nucleotides In The Nervous System
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Author : John Daly
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cyclic Nucleotides In The Nervous System written by John Daly and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The elucidation of the cellular and molecular bases underlying the inte grated function of the central nervous system, both in disease and in health, must ultimately come from the combined efforts of scientists from many disciplines, including biology, chemistry, histology, pathology, physiology, pharmacology, and psychology. Communication between scientists from these various disciplines-vital to the advancement of our understanding of the function of the nervous system-has become more and more difficult in recent years. Both increasing specialization and the incredible increases in publications pertinent to brain research in a wide spectrum of journals, in symposium volumes, in monographs, in abstracts, and in reviews contrib ute to the problems of cross-communication and even of communication within a scientific discipline. Research on the significance of cyclic nucleo tides to the function of nervous systems is particularly illustrative of the communication problem. Since the initial publications by Sutherland, Rall, and Butcher in the late fifties and early sixties on high levels of adenylate cyclase, phosphodiesterases, and cyclic AMP in brain, the ensuing litera ture of this field has expanded exponentially. At the present time, from five to ten publications relevant to cyclic nucleotides and the nervous system appear each week. Indeed, these are minimal numbers based mainly on examination of literature titles and key index words. Many articles concerned with some aspect of central function contain, buried within their text, experiments with or related to cyclic nucleotides.
Immediate Early Genes And Inducible Transcription Factors In Mapping Of The Central Nervous System Function And Dysfunction
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Author : L. Kaczmarek
language : en
Publisher: Gulf Professional Publishing
Release Date : 2002-07
Immediate Early Genes And Inducible Transcription Factors In Mapping Of The Central Nervous System Function And Dysfunction written by L. Kaczmarek and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-07 with Medical categories.
This book brings together information about the most widely studied IEG/ITF involved in a variety of neuronal activation. Written by a prominent group of authors, it attempts to unravel the complexity of the phenomena of gene expression in the central nervous system.
Cytoskeleton Of The Nervous System
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Author : Ralph A. Nixon
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-04
Cytoskeleton Of The Nervous System written by Ralph A. Nixon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-04 with Medical categories.
This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.
Protein Folding Disorders Of The Central Nervous System
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Author : Ghiso Jorge A
language : en
Publisher: World Scientific
Release Date : 2017-09-15
Protein Folding Disorders Of The Central Nervous System written by Ghiso Jorge A and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-15 with Medical categories.
This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by their relationship to structural transitions in the native state of specific proteinaceous components, which for reasons poorly understood, convert into polymeric aggregates that generate poorly soluble tissue deposits and which are considered today the culprit of the disease pathogenesis in their respective diseases. Despite the diversity in the amino acid sequence of the different proteins involved in these heterogeneous disorders, all the pathologic conformers can trigger cascades of events ultimately resulting in cell dysfunction and death with devastating clinical consequences in many of the most precious aspects of human existence including personality, cognition, memory, and skilled movements. This book, which is composed of a compilation of chapters authored by outstanding and well-published scientists in the respective fields currently performing active investigations at world renowned universities and research centers, focuses on the growing number of diseases associated with protein misfolding in the central nervous system. Individual chapters are dedicated to the most common neurodegenerative diseases associated with protein aggregation/fibrillization focusing on the nature of the pathogenic species and the cellular pathways involved in the molecular pathogenesis of Alzheimer's, Parkinson's, and Huntington's diseases as well as in Amyotrophic Lateral Sclerosis, and Prion disorders. A group of contributions is centered on the current knowledge of the intracellular pathways and subcellular organelles affected by the different disease conditions, while others are focused in the emerging pathogenic role of misfolded subunits assembled into neurotoxic soluble oligomers, and in the novel notion of the transmissibility of the protein misfolded species, an innovative concept until recently only accepted for Prion diseases. Lastly, a different set of chapters is dedicated to the evaluation of novel therapeutic strategies for these devastating diseases. Contents: Misfolding, Aggregation, and Amyloid Formation: The Dark Side of Proteins (Agueda Rostagno and Jorge A Ghiso)Oligomers at the Synapse: Synaptic Dysfunction and Neurodegeneration (Emily Vogler, Matthew Mahavongtrakul, and Jorge Busciglio)Prion-Like Protein Seeding and the Pathobiology of Alzheimer's Disease (Lary C Walker)The Tau Misfolding Pathway to Dementia (Alejandra D Alonso, Leah S Cohen, and Viktoriya Morozova)The Biology and Pathobiology of α-Synuclein (Joel C Watts, Anurag Tandon, and Paul E Fraser)Impact of Loss of Proteostasis on Central Nervous System Disorders (Sentiljana Gumeni, Eleni N Tsakiri, Christina-Maria Cheimonidi, Zoi Evangelakou, Despoina Gianniou, Kostantinos Tallas, Eleni-Dimitra Papanagnou, Aimilia D Sklirou, and Ioannis P Trougakos)Protein Misfolding and Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis (Giovanni Manfredi and Hibiki Kawamata)Impact of Mitostasis and the Role of the Anti-Oxidant Responses on Central Nervous System Disorders (Sentiljana Gumeni, Eleni N Tsakiri, Christina-Maria Cheimonidi, Zoi Evangelakou, Despoina Gianniou, Kostantinos Tallas, Eleni-Dimitra Papanagnou, Aimilia D Sklirou, and Ioannis P Trougakos)Propagation of Misfolded Proteins in Neurodegeneration: Insights and Cautions from the Study of Prion Disease Prototypes (Robert C C Mercer, Nathalie Daude,
Cyclic Nucleotides Phosphorylated Proteins And Neuronal Function
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Author : Paul Greengard
language : en
Publisher:
Release Date : 1978
Cyclic Nucleotides Phosphorylated Proteins And Neuronal Function written by Paul Greengard and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Medical categories.
Regulatory Protein Modification
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Author : Hugh C. Hemmings
language : en
Publisher: Neuromethods
Release Date : 1997
Regulatory Protein Modification written by Hugh C. Hemmings and has been published by Neuromethods this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
Annotation Reviews the major categories of posttranslational protein modification in neurons and presents techniques for their analysis. Details methods for studying protein phosphorylation/dephosphorylation, methylation, long chain fatty acylation, ADP-ribosylation, glycosylation, and glycosylphospatidylinositol anchors using both conventional analytical and novel molecular biological approaches. Includes a complete review of protein kinase and phosphatase inhibitor applications. For neuroscientists, molecular biologists, and pharmacologists. Annotation c. by Book News, Inc., Portland, Or.