Cytochrome P450 Part B
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Cytochrome P450
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Author :
language : en
Publisher:
Release Date : 1996
Cytochrome P450 written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Cytochrome P450 Part B
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Author :
language : en
Publisher:
Release Date : 1996
Cytochrome P450 Part B written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Cytochrome P-450 categories.
Methods In Enzymology
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Author : Nathan O. Kaplan
language : en
Publisher:
Release Date : 1996
Methods In Enzymology written by Nathan O. Kaplan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Cytochrome P-450 categories.
Cytochrome P450 Part B
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Author :
language : en
Publisher: Academic Press
Release Date : 1996-09-17
Cytochrome P450 Part B written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-09-17 with Science categories.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 270 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * Methods presented for * Heterologous expression of P450s * Enzyme assays * Determination of genotype * Insect P450s * Analysis of P450 structure * Regulation
Cytochromes P450
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Author : Costas Ioannides
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008-06-27
Cytochromes P450 written by Costas Ioannides and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-27 with Science categories.
During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P 450 enzymes. With its discovery in 1958 and with the advent of more refined spectroscopic methodologies, through the double wavelength spectrophotometry, the mysterious enzyme system began to reveal its secrets in a swift stream of investigative successes. As one of the most extensively studied enzyme systems worldwide the interest in cytochromes P450 very much reflects its importance in the elimination of drugs and other chemicals from the body and its role in chemical toxicity and in the aetiology of diseases such as cancer. There has been significant progress in research in this area in recent years and current books on this subject are now out of date. This much needed, new, fully up-to-date publication fills this gap and emphasises the new relevant topics that have emerged during the last decade in an easily accessible manner. The enzyme system, cytochromes P450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book. Part A of this monograph introduces the reader to the current knowledge of the evolutionary development of cytochrome P450 structure and function. Furthermore, it deals with the role of this enzyme in the formation of reactive intermediates. The shrewd and extensive utilisation of the molecular biology methodology very rapidly led to a vast body of enzymes calling for a classification of the plethora of different cytochromes P450 (the superfamily) into families and subfamilies. This is aptly exemplified by the ten chapters in Part B of this book, dealing with ten subfamilies and two families of cytochrome P450. Part C offers an insight into another aspect of cytochrome P450 research, namely its regulation through receptor-mediated stimuli - as opposed to enzyme induction or inhibition. The final chapter translates the current data on one of several drug metabolising systems into clinical application and highlights the role of cytochromes P450 in the treatment of neoplastic growth. The book deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics. Essential and invaluable information is provided for the industrial research scientist working with fine chemicals, and especially those in the pharmaceutical industry, dealing with the safety evaluation of chemicals or being involved in the study of their metabolism, pharmacokinetics and toxicological properties. It should also prove of interest to Regulators concerned with the safety evaluation of chemicals, research pharmacologists and toxicologists, and postgraduate students studying drug metabolism and toxicology at an advanced level.
Cytochrome P450
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Author : Eric F. Johnson
language : en
Publisher: Elsevier
Release Date : 2002-11-07
Cytochrome P450 written by Eric F. Johnson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-07 with Science categories.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today truly an essential publication for researchers in all fields of life sciences. Human Genomics and Genetics Structure and Mechanism Regulation of Expression Metabolism Invertibrate P450s
Cytochrome P450 Protocols
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Author : Ian R. Phillips
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Cytochrome P450 Protocols written by Ian R. Phillips and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
For this second edition of their much praised Cytochrome P450, the editors have collected accounts of the essential core techniques that use the latest methodologies for the investigation of P450s. Highlights include protocols for spectral analysis and purification of P450s, enzymatic assays of P450s and flavin-containing monooxygenases (FMOs), expression of P450s and FMOs in heterologous systems, and the production and use of antipeptide antibodies. Additional chapters contain readily reproducible techniques for the transfection of hepatocytes for gene regulation studies, P450 reporter gene assays, in situ hybridization, and analysis of genetic polymorphisms. Although the emphasis is on P450s of mammalian origin, many of the readily reproducible methods described are suitable for P450s from any source.
Cytochrome P450
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Author : Eric F. Johnson
language : en
Publisher: Academic Press
Release Date : 2002
Cytochrome P450 written by Eric F. Johnson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Biochemistry categories.
Human genomics and genetics; Structure and mechanism; Regulation of expression; Metabolism; Invertebrate P450s.
Drug Metabolizing Enzymes
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Author : Jae Lee
language : en
Publisher: CRC Press
Release Date : 2003-09-03
Drug Metabolizing Enzymes written by Jae Lee and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-03 with Medical categories.
Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes - as well as parallel issues shaping the pharmaceutical industry - to promote the next generation of safer, more effective drugs.
Methods In Enzymology
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Author : Nathan O. Kaplan
language : en
Publisher:
Release Date : 2002
Methods In Enzymology written by Nathan O. Kaplan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytochrome P-450 categories.