Decoding Multiple Sclerosis
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Precision Medicine In Neurodegenerative Disorders
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-02-16
Precision Medicine In Neurodegenerative Disorders written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-16 with Medical categories.
Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 in the Handbook of Clinical Neurology deals with the "How" in the reconfiguration of our approach to slow accelerated brain aging. The book rethinks animal models on which therapies are tested, outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology, and the growing role of microbiome in shaping disease. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision "medicine"–matching biology with the mechanism of intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes. - Summarizes theory and research on precision medicine in neurodegenerative disorders - Covers basic biology, clinical trials and therapeutics - Includes disease mechanisms, genetic subtypes, and more
Decoding Multiple Sclerosis
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Author : Nilesh Panchal
language : en
Publisher: Independently Published
Release Date : 2024-11-15
Decoding Multiple Sclerosis written by Nilesh Panchal and has been published by Independently Published this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-15 with Medical categories.
Decoding Multiple Sclerosis: A Complete Guide to Understanding and Managing MS offers a comprehensive and accessible exploration of one of the most complex neurological conditions. This book delves into every aspect of Multiple Sclerosis, from its mysterious causes and diverse symptoms to the latest diagnostic tools and cutting-edge treatment options. With a focus on empowering readers, it provides practical strategies for managing daily life, maintaining mental and physical well-being, and navigating the emotional and social challenges of living with MS. Packed with insights from medical experts, patient stories, and the latest research, this guide serves as a vital resource for anyone affected by MS-patients, caregivers, and medical professionals alike-helping them decode the complexities of this condition and find pathways to hope, resilience, and a better quality of life.
Nanomedicine For Inflammatory Diseases
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Author : Lara Scheherazade Milane
language : en
Publisher: CRC Press
Release Date : 2017-09-19
Nanomedicine For Inflammatory Diseases written by Lara Scheherazade Milane and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-19 with Medical categories.
Nanomedicine for Inflammatory Diseases is a cutting-edge resource for clinicians and scientists alike, working at the intersection of development and clinical therapeutics. This text is ideal for graduate level courses in nanomedicine, translational medicine, or inflammatory disease. This book is a progressive hallmark in translational medicine as it unites clinicians treating inflammatory disease with scientists developing experimental nanomedicine therapeutics. The commonality is made through a translational nanomedicine expert – bridging the gap between the laboratory benchtop and the clinical bedside.
Neuroscience Research And Textbook 4
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Author : Aliasghar Tabatabaei Mohammadi
language : en
Publisher: Nobel TM
Release Date :
Neuroscience Research And Textbook 4 written by Aliasghar Tabatabaei Mohammadi and has been published by Nobel TM this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
Neuroscience Research And Textbook 4( restricted repetitive behaviors, ischemic stroke, Dementia, Bipolar spectrum disorders , stem cell, neuropsychiatric and neurological diseases, sleep) For medical students, medical doctors, and researchers.
Microrna
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Author : Jaishree Paul
language : en
Publisher: CRC Press
Release Date : 2018-02-19
Microrna written by Jaishree Paul and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-19 with Medical categories.
This book explores the role of miRNA as therapeutic agents, the progress made in this direction and the problems that need to be addressed for miRNA based therapies to become successful. It also discusses the basic biology of miRNA sythesis, regulation, and their role in disease biology.
Decoding Multiple Sclerosis And Related Disease Parameters Using Structural Brain Mri And Multivariate Analysis Algorithms
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Author : Kerstin Hackmack
language : en
Publisher:
Release Date : 2012
Decoding Multiple Sclerosis And Related Disease Parameters Using Structural Brain Mri And Multivariate Analysis Algorithms written by Kerstin Hackmack and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Danger Signals Triggering Immune Response And Inflammation
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Author : Abdulraouf Ramadan
language : en
Publisher: Frontiers Media SA
Release Date : 2017-09-18
Danger Signals Triggering Immune Response And Inflammation written by Abdulraouf Ramadan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-18 with Diseases categories.
The immune system detects "danger" through a series of what we call pathogen-associated molecular patterns (PAMPs) or damage-associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. PAMPs are molecules associated with groups of pathogens that are small molecular motifs conserved within a class of microbes. They are recognized by Toll-like receptors (TLRs) and other pattern recognition receptors. A vast array of different types of molecules can serve as PAMPs, including glycans and glycoconjugates. Bacterial lipopolysaccharides (LPSs), endotoxins found on the cell membranes of Gram-negative bacteria, are considered to be the prototypical class of PAMPs. LPSs are specifically recognized by TLR4, a recognition receptor of the innate immune system. Other PAMPs include bacterial flagellin (recognized by TLR5), lipoteichoic acid from Gram-positive bacteria, peptidoglycan, and nucleic acid variants normally associated with viruses, such as double-stranded RNA, recognized by TLR3 or unmethylated CpG motifs, recognized by TLR9. DAMPs, also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory response. DAMPs vary greatly depending on the type of cell (epithelial, mesenchymal, etc.) and injured tissue. Some endogenous danger signals include heat-shock proteins, HMGB1 (high-mobility group box 1), reactive oxygen intermediates, extracellular matrix breakdown products such as hyaluronan fragments, neuromediators, and cytokines like the interferons (IFNs). Non-protein DAMPs include ATP, uric acid, heparin sulfate, and DNA. Furthermore, accumulating evidence supports correlation between alarmins and changes in the microbiome. Increased serum or plasma levels of these DAMPs have been associated with many inflammatory diseases, including gastric and intestinal inflammatory diseases, graft-versus-host disease (GVHD), sepsis and multiple organ failure, allergies particularly in the lungs, atherosclerosis, age-associated insulin resistance, arthritis, lupus, neuro-inflammation/degeneration and more recently in tumors, which is particularly interesting with the emergence of immunotherapies. Therapeutic strategies are being developed to modulate the expression of these DAMPs for the treatment of these diseases. A vast number of reviews have already been published in this area; thus, in an effort to not duplicate what has already been written, we will focus on recent discoveries particularly in disease models that are epidemic in Western society: intestinal chronic inflammatory diseases including GVHD and its relationship with the microbiome, chronic infectious diseases, allergies, autoimmune diseases, neuroinflammation and cancers. We will also focus on the basic cellular roles of macrophages, T cells and B cells. This research topic brings together sixteen articles that provide novel insights into the mechanisms of action of DAMPS/alarmins and their regulation and subsequent immunologically driven responses.
Textbook Of Personalized Medicine
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Author : Kewal K. Jain
language : en
Publisher: Humana Press
Release Date : 2015-03-17
Textbook Of Personalized Medicine written by Kewal K. Jain and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-17 with Medical categories.
Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.
Advanced Understanding Of Neurodegenerative Diseases
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Author : Raymond Chuen-Chung Chang
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-12-16
Advanced Understanding Of Neurodegenerative Diseases written by Raymond Chuen-Chung Chang and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-16 with Medical categories.
Advanced Understanding of Neurodegenerative Diseases focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions. Other chapters discuss how hormones and health food supplements affect disease progression of neurodegenerative diseases. From a more technical point of view, some chapters deal with the aggregation of prion proteins in prion diseases. An additional chapter to discuss application of stem cells. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.
Role Of Microorganisms In Pathogenesis And Management Of Autoimmune Diseases
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Author : Mitesh Kumar Dwivedi
language : en
Publisher: Springer Nature
Release Date : 2022-08-10
Role Of Microorganisms In Pathogenesis And Management Of Autoimmune Diseases written by Mitesh Kumar Dwivedi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-10 with Medical categories.
This book in the two volume set provides comprehensive coverage on how microbial pathogens can subvert our immune system into responding against self and resulting into autoimmune diseases. In particular, the book covers the different aspects of linking gut microbiota dysbiosis with autoimmune mechanisms involved in disease development to identify future effective approaches based on the gut microbiota for preventing these autoimmune diseases. Contributions in the book focuses on the role of microbiota/probiotics and their distinct mechanisms exerted in management of autoimmune liver, skin, thyroid, rheumatic and myopathic diseases. This could help in better understanding to design therapeutic strategies that can be deployed to prevent these autoimmune diseases. The book has an interdisciplinary appeal and scholars with an interest immunology, medical microbiology and nutritional sciences will value its contribution. Overall, the book gives a new dimensions and insight in the aspects of microbial role in autoimmune disease pathogenesis and therapeutic aspects.