Decoding The Genomic Control Of Immune Reactions
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Decoding The Genomic Control Of Immune Reactions
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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2007-04-04
Decoding The Genomic Control Of Immune Reactions written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-04 with Science categories.
This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend. Specific problems addressed include the following: What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance? Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues? Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses? Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.
Models And Estimation Of Genetic Effects
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Author : José M Álvarez-Castro
language : en
Publisher: Frontiers Media SA
Release Date : 2015-04-17
Models And Estimation Of Genetic Effects written by José M Álvarez-Castro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-17 with Ecology categories.
Ronald Fisher needed to develop elaborate models of genetic effects in order to set the foundations of Quantitative Genetics in his 1918 paper “The correlation between relatives on the supposition of Mendelian inheritance”. Since then, many significant implementations have been made to model genetic effects. However, at the verge of one century after Fisher’s kick-off, models of genetic effects keep on being discussed and implemented. Indeed, the relatively recent advent of QTL analyses challenged the state of the art of this field by providing researchers the opportunity to obtain and analyze estimates of genetic effects from real data. In this context, the development of this field was not exempt of some polemics, like the debate about the convenience of the functional and the statistical epistasis approaches. This research topic is meant to provide recent developments in models and estimation of genetic effects and to enrich the discussion about how and why models of genetic effects must be further developed and applied. The articles in this Research Topic shall thus extend, refine and/or provide a refresh look at Fisher’s original models of genetic effects and their application to genetic effects estimation and to improve our understanding of evolutionary processes and breeding programs.
Genetic And Epigenetic Control On Immune Responses Regulating Molecules In Cancer Development Progression And Treatment
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Author : Katherine Chiappinelli
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-16
Genetic And Epigenetic Control On Immune Responses Regulating Molecules In Cancer Development Progression And Treatment written by Katherine Chiappinelli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-16 with Medical categories.
In line with recent evidence, the development of cancer has been described as uncontrolled cell growth that results from gradual accumulation of genetic and epigenetic alterations, involving aberrations in oncogenes, tumor suppressor genes, and defects in genes engaged in DNA repair. As a result, cancer cells acquire a neoplastic phenotype and tumor-associated antigens (TAAs) are presented on their surface. These target structures should be recognized by cells of the immune system. However, a sequence of events at the genetic and epigenetic level disturb immune cells, and in consequence, make them unable to eliminate cancer cells. Both innate and adaptive immunity are mobilized against cancer cells. In response to the appearance of cells with malignant transformation, NK cells release perforin and granzyme, causing direct cytolysis of the target cells. They can also secrete pro-inflammatory cytokines and in that way enhance the anticancer response. The activity of NK cells is regulated by a variety of activating and inhibitory receptors including NKG2D, KIR, CD94 -NKG2 heterodimers and natural cytotoxicity receptors, TNF family ligands, as well as co-stimulatory receptors, which recognize related molecules on target cells. A fundamental trigger of the anticancer immune response is the recognition of TAAs by T cells, via the major histocompatibility complex (MHC), which should be followed by signals from co-stimulatory molecules. Full activation of T lymphocytes requires a third signal provided by the presence of cytokines, and this leads to cell proliferation, differentiation, and secretion of chemokines and cytokines. The effect is to drive the clonal expansion of the T cells directed against TAAs and to recruit other immune effector cells in order to enhance immune defense.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1974
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with Medicine categories.
The Software Encyclopedia
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Author :
language : en
Publisher:
Release Date : 1986
The Software Encyclopedia written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Computer industry categories.
Defending Life
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Author : Elling Ulvestad
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-11
Defending Life written by Elling Ulvestad and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-11 with Medical categories.
Defending Life discusses the relationship between hosts and parasites. It contains detailed descriptions of the immune system and the microbial world as well as methodological and conceptual clarifications. Its emphasis on analytical abstractions, coherent patterns and generative mechanisms makes possible the distinction between genuine causality and coincidental associations and increases the understanding of why we observe what we observe.
Principles Of Virology
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Author : S. Jane Flint
language : en
Publisher: John Wiley & Sons
Release Date : 2015-08-03
Principles Of Virology written by S. Jane Flint and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-03 with Science categories.
Principles of Virology is the leading virology textbook because it does more than collect and present facts about individual viruses. Instead, it facilitates an understanding of basic virology by examining the shared processes and capabilities of viruses. Using a set of representative viruses to present the complexity and diversity of a myriad of viruses, this rational approach enables students to understand how reproduction is accomplished by known viruses and provides the tools for future encounters with new or understudied viruses. This fully updated edition represents the rapidly changing field of virology. A major new feature is the inclusion of 26 video interviews with leading scientists who have made significant contributions to the field of virology. Applicable courses: undergraduate courses in virology and microbiology as well as graduate courses in virology and infectious diseases.
Frontiers In Combating Antibacterial Resistance Current Perspectives And Future Horizons
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Author : Grewal, Ajmer Singh
language : en
Publisher: IGI Global
Release Date : 2024-03-25
Frontiers In Combating Antibacterial Resistance Current Perspectives And Future Horizons written by Grewal, Ajmer Singh and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-25 with Medical categories.
The rise of modern antimicrobial drug resistance has evolved into a pressing global health crisis, challenging the very foundation of our ability to combat infectious diseases. The overuse and accessibility of antibiotics, particularly in emerging nations, have given rise to resilient "superbugs," rendering common medications ineffective. This escalating challenge poses a significant threat to public health and leads to heightened healthcare costs, prolonged patient stays, and increased mortality rates. As communities grapple with the urgent need for a coordinated response, a comprehensive understanding of antimicrobial drug resistance and innovative strategies becomes paramount. Frontiers in Combating Antibacterial Resistance: Current Perspectives and Future Horizons is meticulously crafted for academic scholars, researchers, and healthcare professionals. It addresses this critical issue head-on and serves as a beacon of knowledge and a solution-oriented guide. With a focus on elucidating the mechanisms behind antimicrobial drug resistance and exploring emerging therapeutic targets, the book presents an in-depth analysis of the problem. It spans environmental, genetic, and climatic factors influencing resistance, delving into cutting-edge technologies and sustainable strategies for prevention. By offering a holistic view of the issue and proposing evidence-based solutions, the book is an indispensable resource for those seeking to navigate the complex landscape of antimicrobial drug resistance.
Parliamentary Papers
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Author : Australia. Parliament
language : en
Publisher:
Release Date : 1975
Parliamentary Papers written by Australia. Parliament and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with categories.
Scientific And Technical Aerospace Reports
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Author :
language : en
Publisher:
Release Date : 1984
Scientific And Technical Aerospace Reports written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Aeronautics categories.