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Detection Challenges In Clinical Diagnostics

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Detection Challenges In Clinical Diagnostics

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Author : Pankaj Vadgama
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013

Detection Challenges In Clinical Diagnostics written by Pankaj Vadgama and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.

There are many remaining challenges impeding future progress in field of Clinical Diagnostics. This book presents a technical assessment and vision of clinical leaders, scoping the clinical and other diagnostic needs and the bottle-necks in their cognate fields. Issues of real environmental biological measurements from the perspective of the end-user are presented and thus the book serves to inform the direction of the fundamental scientific efforts. Both editors are experienced practitioners within the biosensor technology and are involved first-hand with the healthcare and clinical applications of detection science.

Improving Diagnosis In Health Care

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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2015-12-29

Improving Diagnosis In Health Care written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-29 with Medical categories.

Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.

Advances And Challenges In The Detection And Treatment Of Pathogenic Microorganisms In Infectious Disease Control

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Author : Jun Feng
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-04

Advances And Challenges In The Detection And Treatment Of Pathogenic Microorganisms In Infectious Disease Control written by Jun Feng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-04 with Science categories.

Detection Challenges In Clinical Diagnostics

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Author : Pankaj Vadgama
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013-09-23

Clinical Diagnostic Technology

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Author : Kory M. Ward
language : en
Publisher: Amer. Assoc. for Clinical Chemistry
Release Date : 2003

Clinical Diagnostic Technology written by Kory M. Ward and has been published by Amer. Assoc. for Clinical Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.

Detection Methods In Precision Medicine

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Author : Mengsu (Michael) Yang
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-12-10

Detection Methods In Precision Medicine written by Mengsu (Michael) Yang and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-10 with Science categories.

Precision medicine is a topical subject that attracts tremendous attention from scientific and medical communities, being set to transform health care in the future. This book will be among the first to cover the detection methods for precision medicine. The first section provides an overview of the biomarkers used for precision medicine, such as proteins, nucleic acids, and metabolites. The coverage then turns to sequencing techniques and their applications, and other bioanalytical techniques, including mass spectrometry for proteome and phosphoproteome analysis, immunological methods and droplet technologies. The final sections include biosensors applied to precision medicine and clinical applications. This book provides a reference for researchers and students interested and working in the development of bioanalytical techniques for clinical applications. It provides a useful introduction for physicians and medical laboratory technologists to the recent advances in detection methods for precision medicine.

Contemporary Challenges In Immunologic Testing In Clinical And Research Laboratories

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Author : Pablo Engel
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-24

Contemporary Challenges In Immunologic Testing In Clinical And Research Laboratories written by Pablo Engel and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-24 with Medical categories.

Along the last several decades, it has been progressively appreciated that immunology plays an overwhelming role in the physiology and pathophysiology of most organs, tissues, and biological systems in multicellular organisms. Accordingly, several immunological parameters are used in research and clinical laboratories with the purpose of investigating, diagnosing, and monitoring a variety of pathological conditions. The rapidly evolving field of laboratory testing in immunology poses several challenges to professionals working in research and clinical laboratories, medical practice, educational activities, in vitro diagnostic industry, and regulatory agencies. Regular analytes, such as albumin, glucose, and insulin, are homogeneous among individuals of the same species. This property represents an advantage when it comes to optimize the determination methods as well as to establish standardization and quality assessment strategies. In contrast, several immunologic analytes present tremendous variability across individuals in the same species. In fact, some are unique at the individual level. For example, the repertoire of immunoglobulins specific for a given pathogen (e.g., rubella) is specific for each individual in terms of the balance of targeted antigens and epitopes, immunoglobulin isotypes, antibody avidity, Fc glycosylation rate, and so on. As a corollary, the panel of anti-rubella antibodies is necessarily different from one to other individual. This also applies to autoantibodies and to IgE to allergens. Polymorphism is prevalent for other immunologic parameters, such as Complement components, cell receptors (cluster differentiation molecules - CD) and downstream signal transduction mediators.

Protein Biomarkers Discovery And Applications In Clinical Diagnostics

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Author : Sumit Kumar Singh
language : en
Publisher: Springer Nature
Release Date : 2025-01-17

Protein Biomarkers Discovery And Applications In Clinical Diagnostics written by Sumit Kumar Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-17 with Medical categories.

This book comprehensively reviews the fundamentals of biomarker discovery using mass-spectrometry-based proteomic and glycoproteomic methods. It also provides case studies of proteomic and glycoproteomic molecular signatures to illustrate the design and use of various mass spectrometry modes such as selected reaction monitoring (SRM), parallel reaction monitoring (PRM), and sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS). In turn, the book presents the challenges of the proteomic methods in biomarker discovery and approaches for overcoming these challenges by extending the performance by improving the sensitivity, throughput, and selectivity of the method. It also addresses the bottleneck of deriving useful biological interpretations from large multi-dimensional datasets emanating from these experiments by discussing data analysis pipelines and appropriate statistical analysis. Finally, a detailed discussion on the design, characterization, and application of protein/glycoprotein-based biosensors for clinical diagnostics is discussed. The book is intended to serve as a reliable resource for the students and researchers working in the area of biomarker discovery and validation using mass spectrometry-based methods and their subsequent applications for biosensor design.

Current Challenges In Complement Diagnostics

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Author : Erik J.M. Toonen
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-14

Current Challenges In Complement Diagnostics written by Erik J.M. Toonen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-14 with Medical categories.

The complement system is an important innate immune surveillance network that has a key role in protecting our bodies against pathogens and other threats. It is a highly complex system consisting of approximately 50 soluble and cell surface-bound proteins that interact to eliminate danger signals. These signals include factors such as invading microorganisms, necrotic cells, and immune complexes. Furthermore, complement can link innate and adaptive immune responses by regulating T cell and B cell responses. The complement system is tightly regulated to avoid uncontrolled activation. Dysregulation of the complement system has been linked to numerous diseases, both rare and common. Uncontrolled or exaggerated activation can lead to life-threatening conditions such as dysregulation of coagulation, fibrinolysis, systemic inflammation and shock, and possible failure of a variety of organs such as the eyes, kidneys, skin, brain, and vascular system. In recent years, the complement system has gained increased interest, especially as a promising candidate for therapeutic intervention. Eculizumab, the first approved complement inhibitor, is highly effective for treating atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH). Many more drug candidates are currently evaluated in ongoing clinical trials.

Sensing Materials And Devices For Biomarkers

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Author : Vishal Mutreja
language : en
Publisher: Royal Society of Chemistry
Release Date : 2024-12-20

Sensing Materials And Devices For Biomarkers written by Vishal Mutreja and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-20 with Science categories.

Providing a comprehensive look at the state-of-the-art detection technologies and materials used in the development of diagnostics for clinical, medicinal and environmental applications, the books in this series are a valuable reference for graduate students and professional researchers across academia and industry. Emphasising the detection of chemicals and biochemical species in a quantitative fashion, the in-depth knowledge featured in the series will also interest advisors, consultants and government agency staff.

Detection Challenges In Clinical Diagnostics

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