Development Of Circadian Clock Functions

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Development Of Circadian Clock Functions

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Author : Daisuke Ono
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-01

Development Of Circadian Clock Functions written by Daisuke Ono and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-01 with Science categories.

Development Of Circadian Clock Functions Volume Ii

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Author : Daisuke Ono
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-31

Development Of Circadian Clock Functions Volume Ii written by Daisuke Ono and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-31 with Science categories.

The temporal order of physiological functions such as sleep/wakefulness is regulated by the circadian clock. This intrinsic clock starts ticking in the embryo and matures during development, with attenuation of the clock function in the elderly, illustrated by attenuation of synchrony, entrainment, and outputs of cellular circadian rhythms in the SCN. This age-related diminution can contribute to the emergence of diseases, such as sleep disorders, infertility, diabetes, mental disorders etc. Over the course of our lives, a variety of internal and external factors are under the influence of the circadian clock. This inherent developmental plasticity of the circadian system is critical for the establishment of normal bodily functions to adapt to the changing environment on earth. In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Circadian rhythms in the SCN are observed during the embryonic period, and input and output pathways from the SCN are formed after birth. During postnatal development, functions of neurotransmitters in the SCN are changed, which have an influence on special temporal patterns of circadian rhythms in the SCN and outputs signals to the outside of the SCN. During postnatal development properties of circadian rhythms in the SCN and its inputs and outputs can be modulated by environmental light conditions. Recent optical manipulation and imaging techniques have revealed that cell type specific functions for circadian rhythms. However, it remains unclear which cell types or networks in the brain are modulated during postnatal development, and how these cells regulate circadian rhythms depending on postnatal period.

Human Circadian Physiology

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Author : Charles A. Czeisler
language : en
Publisher:
Release Date : 1978

Human Circadian Physiology written by Charles A. Czeisler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Human physiology categories.

Therapeutic Implications Of Circadian Rhythms

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Author : Guangrui Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2015-10-12

Therapeutic Implications Of Circadian Rhythms written by Guangrui Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-12 with Circadian rhythms categories.

Circadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed in both the suprachiasmatic nucleus (SCN), the master clock residing in the hypothalamus, and almost all peripheral tissues where they control numerous target genes in a circadian manner, and thus affect many physiological and biochemical processes. Evidence suggests that disruption of the circadian rhythms (or desynchronization) is a significant risk factor for the development of metabolic diseases, cardiovascular diseases, cancer and sleep disorders. Evidence also suggests that the disruption suppresses immune function and increases vulnerability to infectious diseases. Restoring or strengthening the circadian rhythm may be therapeutic for these conditions. This becomes exceptionally important in modern societies because many people are suffering from frequent desynchronization due to shift working, exposure to artificial light, travel by transmeridian air flight, and involvement in social activities. Besides, the temporal variations in the incidence and severity of many diseases, such as the onset of cardiovascular events, chronic obstructive pulmonary disease (COPD), inflammatory diseases and mental disorders have also drawn increasing attention to the circadian clock. The circadian rhythms affect not only the health status, but also the drug efficiency. The effects (and side effects) of many drugs vary with biological timing. The tolerance of many medications displays circadian variation as well. The timing of medical treatment in coordination with the body clock may significantly increase the desired effects of drugs, and lower the dose and toxicity. In addition, circadian rhythms can also be modulated by some therapeutic drugs, for example, melatonin and modafinil, which are used to treat circadian rhythm sleep disorders. In this Research Topic, we assemble a series of critical review and research articles that focus on the therapeutic implications of circadian rhythms. Topics include, but are not limited to: • Circadian disruption caused diseases or disorders and related intervention • Temporal manifestation of diseases or disorders and therapeutic implications • The effects of circadian rhythms on drugs • The effects of drugs on circadian rhythms

Rna Regulation In Development And Disease

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Author : Maritza Jaramillo
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-15

Rna Regulation In Development And Disease written by Maritza Jaramillo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-15 with categories.

Contemporary Models In Ectodermal Organ Development Maintenance And Regeneration

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Author : Isabelle Miletich
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-12

Contemporary Models In Ectodermal Organ Development Maintenance And Regeneration written by Isabelle Miletich and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-12 with Science categories.

The Biology Of Sole

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Author : José A. Munoz-Cueto
language : en
Publisher: CRC Press
Release Date : 2019-05-13

The Biology Of Sole written by José A. Munoz-Cueto and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-13 with Nature categories.

This book reviews up-to-date knowledge on the biology of sole (Solea senegalensis and S. solea). These flatfish species are increasingly important in Europe both from the ecological and production point of view. This book is divided into two sections: A. general fisheries, aquaculture and engineering overviews; B. physiological, developmental, rhythmic, welfare and genetic aspects which will be of immense interest for the aquaculture industry. Experts, from both academia and research institutes, provide their expertise on sole biology.

Chronobiology And Chronomedicine

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Author : Germaine Cornelissen
language : en
Publisher: Royal Society of Chemistry
Release Date : 2024-02-23

Chronobiology And Chronomedicine written by Germaine Cornelissen and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-23 with Science categories.

Circadian rhythms have been shown to be ubiquitous and critically important in the experimental laboratory, accounting for the difference between life and death in response to identical stimulus. The partly endogenous nature of circadian rhythms has been well documented and methods for their characterisation have been developed enabling the cellular and molecular mechanisms to be understood. Chronobiology and Chronomedicine aims to provide a review of these mechanisms underlying circadian rhythms and illustrate the role of the brain’s suprachiasmatic nuclei in the ‘pace-making’ process and the effects caused by ‘clock genes’ present in almost all cells. Beyond the mechanisms involved, the book discusses the relationship between body systems, disease, and proper circadian function; in particular, how disruption of the circadian rhythm is associated with ill health and disease status from observations made at the organismic level. The book is organised to be an ideal introduction for the postgraduate in various fields, reviewing developments and outlining methods to show the depth and breadth of chronobiology and chronomedicine, as well as an invaluable companion to researchers and healthcare professionals working in the field with an interest in developing novel therapeutic approaches.

Novel Regulatory Mechanisms Behind Thermogenesis Of Brown And Beige Adipocytes

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Author : Rubén Cereijo
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-19

Novel Regulatory Mechanisms Behind Thermogenesis Of Brown And Beige Adipocytes written by Rubén Cereijo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-19 with Medical categories.

Undetermined Implications Of Chronutrition A Missing Curriculum In Medicine

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Author : Reza Rastmanesh
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-25

Undetermined Implications Of Chronutrition A Missing Curriculum In Medicine written by Reza Rastmanesh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-25 with Medical categories.