Developmental Biology Of Neoplastic Growth
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Developmental Biology Of Neoplastic Growth
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Author : Alvaro Macieira-Coelho
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-30
Developmental Biology Of Neoplastic Growth written by Alvaro Macieira-Coelho and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-30 with Science categories.
In this book, tumour growth is perceived as a deviation from the normal development of the human organism. The molecular, cellular, and tissue determinants of different tumours are discussed showing that each is a different disease, often corresponding to a particular developmental stage. The natural history of several cancers illustrates how clinical incidence can be just the visible part of the iceberg, while the first changes at the tissue level sometimes occur several years before tumour growth becomes manifest. Several mechanisms are proposed to explain the distribution of cancers during the human life span and the decline of the incidence of cancers during human senescence.
Neoplastic Development
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Author : Leslie Foulds
language : en
Publisher:
Release Date : 1969
Neoplastic Development written by Leslie Foulds and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1969 with Developmental biology categories.
Neoplasms Principles Of Development And Diversity
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Author : Jules J. Berman
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2009
Neoplasms Principles Of Development And Diversity written by Jules J. Berman and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
This unique text is devoted to the full range of neoplastic properties exhibited by the comprehensive collection of human neoplasms. Like no other book of it's kind, it approaches cancer biology by surveying the diversity of neoplasms and by building a classification of neoplasms based on an understanding of the cellular options for tumor development. By grouping neoplasms into a comprehensive classification, we can develop class-specific methods to prevent, detect, and treat cancers. The book is divided into three broad units: speciation, classification and eradication. In the process of developing a classification for neoplasms, dozens of the fundamental questions in neoplastic development are asked and answered. Neoplasms provides readers with a fascinating and enjoyable way to learn the otherwise arcane and dense subject of human tumor diversity.
Developmental Biology And Cancer
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Author : Gisele M. Hodges
language : en
Publisher: CRC Press
Release Date : 1993-09-27
Developmental Biology And Cancer written by Gisele M. Hodges and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-09-27 with Science categories.
This book addresses possible analogies between cancer and developmental biology. An international group of experts provides a multidisciplinary approach, allowing biological or clinical scientists involved with cancer research to integrate specific information from diverse areas. Five concepts of cancer are presented, and developmental biology is reviewed at five levels. These are integrated in discussions of failure in organisation as a basis of cancer and its control. The book will be a valuable reference for both newcomers as well as experienced biological and clinical scientists. Features
Hormones And Growth Factors In Development And Neoplasia
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Author : Robert B. Dickson
language : en
Publisher: Wiley-Liss
Release Date : 1998-05-06
Hormones And Growth Factors In Development And Neoplasia written by Robert B. Dickson and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-05-06 with Family & Relationships categories.
Hormones and Growth Factors in Development and Neoplasia Edited by Robert B. Dickson, Lombardi Cancer Research Center, Georgetown University David S. Salomon, Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH The study of hormones is critical to our understanding of developmental aberrations leading to cancer, and the discovery of polypeptide growth factors has led to profound insights into the duality of control of development and cancer by hormones at the tissue and cellular levels. In this book, leading researchers in the field present a cohesive overview of several important growth factor systems and how they interact with endocrine hormones in the context of tissue-tissue interactions; control of cellular growth, differentiation, and death; and reciprocal control of receptors and ligands at the molecular level. In its first two sections, Hormones and Growth Factors in Development and Neoplasia introduces important growth factors and hormonal systems in invertebrate and amphibian model systems, highlights early evolutionary and developmental functions for the classes of molecules later shown to be important in human cancer, establishes the roles of growth factors and hormones in mammalian development, and focuses on early embryonic events and later events leading to sexual dimorphism. The book's third section discusses in detail the control of postnatal developmental processes in male and female reproductive tracts, focusing on the prostate and mammary glands as well as the female reproductive tract, all of which are of special importance in hormonally driven cancers. Finally, the book takes a direct look at cancers and the molecular mechanisms of hormone-growth factor interactions. Among the many topics covered in this timely volume are: * Ecdysone in development of Drosophila * The progesterone receptor in mammalian development * Regulation of cell survival and apoptosis in the reproductive tracts and the breast * Hormones, growth factors, oncogenes, and prostate cancer With its novel approach, authoritative coverage, and broad scope, Hormones and Growth Factors in Development and Neoplasia is informative and relevant for researchers across a spectrum of disciplines, including cancer research, endocrinology, developmental biology, and cell biology.
The Cell Surface In Development And Cancer
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Author : Malcolm S. Steinberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
The Cell Surface In Development And Cancer written by Malcolm S. Steinberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
This series was established to create comprehensive treatises on specific topics in developmental biology. Such volumes serve a useful role in developmental biology, since it is a very diverse field that receives contributions from a wide variety of disciplines. This series is a meeting-ground for the various practi tioners of this science, facilitating an integration of heterogeneous information on specific topics. Each volume is intended to provide the conceptual basis for a comprehen sive understanding of its topic as well as an analysis of the key experiments upon which that understanding is based. The specialist in any aspect of devel opmental biology should understand the experimental background of the field and be able to place that body of information in context to ascertain where additional research would be fruitful. At that point, the creative process gener ates new experiments. This series is intended to be a vital link in that ongoing process of learning and discovery.
Asymmetric Cell Division In Development Differentiation And Cancer
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Author : Jean-Pierre Tassan
language : en
Publisher: Springer
Release Date : 2017-04-12
Asymmetric Cell Division In Development Differentiation And Cancer written by Jean-Pierre Tassan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-12 with Science categories.
This book provides readers with an overview of the frequent occurrence of asymmetric cell division. Employing a broad range of examples, it highlights how this mode of cell division constitutes the basis of multicellular organism development and how its misregulation can lead to cancer. To underline such developmental correlations, readers will for example gain insights into stem cell fate and tumor growth. In turn, subsequent chapters include descriptions of asymmetric cell division from unicellular organisms to humans in both physiological and pathological conditions. The book also illustrates the importance of this process for evolution and our need to understand the background mechanisms, offering a valuable guide not only for students in the field of developmental biology but also for experienced researchers from neighboring fields.
Growth Cancer And The Cell Cycle
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Author : Philip Skehan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Growth Cancer And The Cell Cycle written by Philip Skehan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Cancer And Development
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Author :
language : en
Publisher: Academic Press
Release Date : 2011-03-28
Cancer And Development written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-28 with Medical categories.
In recent years, a number of molecular pathways and cellular processes that are essential for normal vertebrate development have been implicated in cancer initiation and progression. In this volume, leaders in the field of cancer genetics and developmental biology share recent insights into the importance of developmental pathways for tumorigenesis. These discoveries provide important avenues for innovative new approaches to treating some of the most challenging developmental tumors. Provides researchers an overview and synthesis of the latest research findings and contemporary thought in the area There are now a large number of molecular targeted therapies for the treatment of cancer. Many of these therapies target pathways that are essential for normal development. Therefore, this volume provides an up-to-date and timely perspective on those pathways and biological processes that hold the greatest promise for targeted intervention.
Genetics Of Human Neoplasia
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Author : R.S. Verma
language : en
Publisher: Elsevier
Release Date : 1995-09-25
Genetics Of Human Neoplasia written by R.S. Verma and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-09-25 with Medical categories.
The underlying idea that cancer is a genetic disease at the cellular level was postulated over 75 years ago when Boveri hypothesised that the malignant cell was one that had obtained an abnormal chromatin content. However, it has been only the last decade where enormous strides have been made toward understanding neoplastic development. Explosive growth in the discipline of cancer genetics is so rapid that any attempt to review this subject becomes rapidly outdated and continuous revisions are warranted. Conclusive evidence has been reached associating specific chromosomal abnormalities to various cancers. We have just begun to characterise the genes, which are involved in these consistent chromosomal rearrangements resulting in the elucidation of the mechanisms of neoplastic transformation at a molecular level. The identification of over 50 oncogenes has led to a better understanding of the physiological process. Tumor suppresser genes, which were discovered through inheritance mechanisms, have further shed some light towards understanding the loss of heterozygosity during carcinogenesis. The message emerging with increasing clarity concerning specific pathways which regulate the fundamental process of cell division and uncontrolled growth. The advances in molecular biology have led to a major insight in establishing precise diagnosis and treatment of many cancers resulting in prevention of death. The field is expanding so rapidly that a complete account of all aspects of genetics of cancer could not be accommodated within the scope of a single volume format. Nevertheless, a few very specific topics have been chosen, which readers may find of great interest in hopes that their interest may be rejuvenated concerning the bewildering nature of this deadly disease. The contributors to Volume 3 have provided up-to-date accounts of their fields of expertise. Although the contributors have kept their chapters brief, they include an extensive bibliography for those who wish to understand a particular topic in depth. For more than a century, cancer has been diagnosed on the enigmatic basis of morphological features. Establishing a diagnosis based on DNA, RNA, and proteins, which is done routinely now, was once inconceivable. Cloning a gene of hematopoietic origin is no longer a fantasy. The approach has shifted over the past 15 years from identification of chromosomal abnormalities toward zeroing in on cancer genes.