Diabetes And Protein Glycosylation
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Diabetes And Protein Glycosylation
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Author : Margo Panush Cohen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Diabetes And Protein Glycosylation written by Margo Panush Cohen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In the years since the initial discovery that blood from diabetic patients contains increased amounts of a posttranslationally gluco sylated form of hemoglobin (hemoglobin Ale)' an impressive number of studies have clarified and expanded the use of glycohemoglobin levels to assess disease status. Many other structural proteins have been shown to undergo similar changes, including proteins from tissues most commonly affected in diabetes (e.g., lens, aorta, peripheral nerve, basement membrane). Thus, the nonenzymatic glycosylation of hemoglobin emerges as an invaluable model for the pathogenesis of certain chronic diabetes complications. In addition to reviewing a wealth of investigative possibilities in the area of these chronic complications-including eye, kidney, nerve, and vascular disease-Dr. Cohen indicates how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for maintenance of long-term euglycemia. Dr. Cohen is an endocrinologist and diabetes specialist whose research activities have largely focused on the chemistry and metabo lism of the basement membrane in diabetes. This superb monograph on nonenzymatic glycosylation clearly shows the major trends of her past and present research and clinical activities. This book is beautifully written and a pleasure to read. It provides great insight into the mechanisms of the pathogenesis of the oom- vii viii Foreword cations of diabetes and should be of immense value not only to basic and clinical investigators, but also to internists, diabetologists, and endocrinologists in clinical practice.
Fundamentals Of Glycosylation
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Author : Alok Raghav
language : en
Publisher: BoD – Books on Demand
Release Date : 2022-01-26
Fundamentals Of Glycosylation written by Alok Raghav and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-26 with Science categories.
The diverse phenomenon of post-translational modifications of biological macromolecules (proteins, lipids, and nucleic acids) includes phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation, and proteolysis. The mechanism of protein glycosylation has an important role in the regulation of human health. This book identifies the fundamentals of glycosylation that help in understanding the concepts of protein glycosylation and its significance.
Diabetes And Protein Glycation
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Author : Margo P. Cohen
language : en
Publisher: J. C. Press
Release Date : 1996
Diabetes And Protein Glycation written by Margo P. Cohen and has been published by J. C. Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Diabetes categories.
The Role Of Glycosylation In Health And Disease
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Author : Gordan Lauc
language : en
Publisher: Springer Nature
Release Date : 2021-09-08
The Role Of Glycosylation In Health And Disease written by Gordan Lauc and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-08 with Science categories.
Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.
Protein Glycosylation Advances In Identification Characterization And Biological Function Elucidation Using Mass Spectrometry
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Author : Ganglong Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-14
Protein Glycosylation Advances In Identification Characterization And Biological Function Elucidation Using Mass Spectrometry written by Ganglong Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-14 with Science categories.
The Polyol Paradigm And Complications Of Diabetes
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Author : Margo P. Cohen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Polyol Paradigm And Complications Of Diabetes written by Margo P. Cohen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In the last decade, it has become increasingly evident that the clini cal and morphologic changes underlying many of the complications of diabetes, including cataract formation, retinopathy, nephropathy, neuropathy, and macrovascular disease, are preceded by a variety of disturbances of biochemical and physiologic origin. Dr. Cohen has recently written a superb monograph, entitled Diabetes and Protein Glycosylation: Measurement and Biologic Relevance, in which she thoroughly explores how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for main tenance of long-term euglycemia. In the present volume, The Polyol Paradigm and Complications of Diabetes, she reviews, in a most succinct and thorough manner, how another biochemical mechan ism, involving the polyol pathway, is involved in the pathogenesis of such diabetes complications as retinopathy, neuropathy, nephropa thy, and cataract formation. Dr. Cohen gives us a clearly written and comprehensive mono graph, reviewing the chemistry of the polyol pathway and of the aldose reductase inhibitors, and the pathophysiologic significance of increased polyol pathway activity in a variety of tissues affected by Vlll Foreword diabetes mellitus. She insightfully describes the relationship of increased polyol pathway activity to altered metabolism of inositol containing phospholipids and to changes in various tissue concentra tions of myo-inositol. Finally, she provides us with a careful review of the existing experimental and clinical studies with a variety of different aldose reductase inhibitors that have been and are being performed in the hope of preventing or reversing long-term compli cations of diabetes.
Human Hemoglobins
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Author : Howard Franklin Bunn
language : en
Publisher: W.B. Saunders Company
Release Date : 1977
Human Hemoglobins written by Howard Franklin Bunn and has been published by W.B. Saunders Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Hemoglobin categories.
Since the dawn of the era of molecular biology, hemoglobin has been subjected to more scrutiny than any other protein, and Bunn, Forget, and Ranney can each lay claim to major contributions to the saga of hemoglobin. Their well-organized, comprehensive, and superbly illustrated work is an excellent review of the abnormal hemoglobin field. Early chapters deal with the structure and function of human hemoglobin and the way in which this is modified in various disease states. Later sections deal with the various structural hemoglobin variants and their associated clinical manifestations, the thalassaemias, and the acquired disorders of hemoglobin. The sections that deal with the modification of hemoglobin function in various disease states are particularly good. The book contains an extensive and up-to-date bibliography and is remarkably free from errors of fact or type--the best standard of reference on the subject as of the year 1977.
Dyslipoproteinaemias And Diabetes
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Author : European Atherosclerosis Group. Meeting
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1985
Dyslipoproteinaemias And Diabetes written by European Atherosclerosis Group. Meeting and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.
The book features clinical and experimental data covering four major topics. General treatment of hyperlipidaemias is reviewed including the efficacy of different drugs. Benefits of treatment by the Lipid Research Clinics Coronary Primary Prevention Trial are shown. The second topic comprises the epidemiological aspects of diabetes. Diabetes and lipoprotein metabolism is the subject of the third are considered. VLDL metabolism and apoprotein metabolism are reviewed and complimented by a general consideration of protein glycosylation and the possible pathophysiological consequences of the glycosylation of LDL and HDL. The final topic reflects the growing interest in the molecural biology of hyperlipidaemias. The genetic determinants of hyperlipidaemias are reviewed as well as links between genetic disorders, diabetes and hyperlipidaemias. [Editeur]
Transforming Glycoscience
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2012-10-23
Transforming Glycoscience written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-23 with Science categories.
A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
Diabetes Remission Through Nutrition
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Author : Antti Heikkilä
language : en
Publisher:
Release Date : 2017-09-29
Diabetes Remission Through Nutrition written by Antti Heikkilä and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-29 with categories.
Reversing type 2 diabetes naturally - without drugs. Life style medicine based on more than 43 years of clinical experience and numerous patient success stories. This book will change the way you look at treating diabetes. Contains delicious real food recipes. Updated version of Nutrition Therapy for Diabetes.-The basic treatment for diabetes should always be a proper diet, says Dr Antti Heikkil�, who has had huge success in Finland when treating his patients with low-carbohydrate, nutrition-rich food. The diet programme in his book, Diabetes Remission Trough Nutrition, is extremely easy to implement in everyday life. You can see the results in a few days. Dr. Heikkil� has helped thousands of patients with diabetes. All of his patients with type 2 diabetes have stopped taking each and every one of their medications. Patients suffering from type 1 diabetes have benefited from this diet as well. Their blood sugar levels have been balanced, and their insulin requirements minimized. They have lost their excess weight and recovered from many other illnesses, such as metabolism syndrome, constant infections, chronic eczema, mood swings, depression and many other problems.In 1984, a diet low in carbohydrates and high in fat was abandoned as the best treatment for people with diabetes when the ADA (American Diabetes Association) concluded that the prevailing low-fat diet was also suitable for diabetics, even though the official dietary recommendations and the benefits of the diet had never been tested in the real world. This was the turning point: medicalization took place and doctors began prescribing drugs without any justification. From that point until today the nutritional advice from the authorities is for a high-carbohydrate, low-fat diet, which is devastating to the health of all diabetics. The only way these patients can survive is to take huge amounts of medicine. The idea of achieving a balance by taking multiple medications only works in theory. The results of such a polypharmacy include multiple side effects, and in many cases, early death. Heart disease, blindness, renal failure and leg amputations are typical complications related to diabetes. In his book, Dr. Heikkil� explains why a natural and nutritional diet low in carbohydrates is so vital that it should always be the first line of defence in the treatment of patients. The basic principle of Dr Heikkil�'s therapy is to maintain the best possible glycemic control and to prevent organ damage caused by sugar. Excess sugar is always harmful, even to those who do not have diabetes. Sugar accelerates the aging process by forming compounds with proteins. The term glycosylation describes this event. The more sugar that circulates in the body, the faster and more extensively glycosylation manifests itself. Glycosylation is a problem for diabetics because it is the cause of all long-term complications related to the disease.Diabetes does not have to be a degenerative and progressive disease. The basic treatment for diabetes should always be a diet with reduced sugar and carbohydrates and consist only secondarily of medicines. The nutritional therapy recommended by Dr Heikkil� is simple: there is no need to calculate anything other than the total amount of carbohydrates. You will learn what plants are low in carbohydrates, which plants have high amounts of carbohydrates, how much protein you need and what are the right fats that you should be using. You will learn why the quality of your food is of vital importance and about the disadvantages of all processed foods. In his book, Dr. Heikkil�, an active gourmet cook, provides two weeks' worth of well-illustrated, delicious and easy-to-make recipes.Diabetes Remission Trough Nutrition contains numerous stories of successful recovery from Dr Heikkil�'s patients.