Discovery And Development Of Anti Breast Cancer Agents From Natural Products
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Discovery And Development Of Anti Breast Cancer Agents From Natural Products
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Author : Goutam Brahmachari
language : en
Publisher: Elsevier
Release Date : 2021-06-24
Discovery And Development Of Anti Breast Cancer Agents From Natural Products written by Goutam Brahmachari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Science categories.
Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields. Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. Highlights active agents from natural sources for development as novel anti-cancer agents Features contributions from active researchers and leading experts working in the field Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines
Discovery And Development Of Anti Cancer Agents From Natural Products
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Author : Felix Cliburn
language : en
Publisher: American Medical Publishers
Release Date : 2023-09-26
Discovery And Development Of Anti Cancer Agents From Natural Products written by Felix Cliburn and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.
Natural products, with remarkable chemical diversity have played a dominant role in the treatment of human ailments. They are considered as a reservoir of bioactive compounds and are extensively investigated for their therapeutic potentials, most notably in the area of cancer therapy. They cannot function as effective drugs in isolation but they can be converted into a drug through chemical modification. There are a variety of widely-used anticancer agents that originate from natural sources, which are structurally unique and function by novel action mechanisms. Some examples of these natural anticancer agents are camptothecin, irinotecan, vincristine, etoposide and paclitaxel derived from plants; actinomycin D and mitomycin C obtained from bacteria; as well as marine-derived bleomycin. Camptothecin is a naturally occurring quinolone alkaloid isolated from wood and bark of Camptotheca acuminate. It is used as a chemotherapeutic agent for treating leukemia. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in the discovery and development of anti-cancer agents from natural products. It includes contributions of experts and scientists which will provide innovative insights into this area of study.
Anticancer Agents From Natural Products Second Edition
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Author : Gordon M. Cragg
language : en
Publisher: CRC Press
Release Date : 2011-10-10
Anticancer Agents From Natural Products Second Edition written by Gordon M. Cragg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-10 with Science categories.
The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.
Bioactive Natural Products For The Management Of Cancer From Bench To Bedside
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Author : Anil K. Sharma
language : en
Publisher: Springer
Release Date : 2019-07-17
Bioactive Natural Products For The Management Of Cancer From Bench To Bedside written by Anil K. Sharma and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-17 with Medical categories.
This book illustrates the importance of the Natural Biometabolites, which offer a rich reservoir of candidate compounds for drug discovery in the battle against cancer. Recent research and development efforts concerning anti-cancer drugs derived from natural products have led to the identification of numerous candidate molecules that inhibit cancer cell proliferation and metastasis using a variety of mechanisms. Given its scope, the book offers a valuable resource for cancer biologists and general oncologists alike, while also benefitting research professionals in Science, Nursing, Medicine, Biochemistry, Genetics and Bioscience who wish to understand the fundamentals of prognosis and prediction in tumorigenesis. Moreover, the book provides an essential platform for understanding drug resistance mechanisms and combatting the growing menace of multidrug resistance.
Natural Products And Cancer Drug Discovery
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Author : Farid A. Badria
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-07-05
Natural Products And Cancer Drug Discovery written by Farid A. Badria and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-05 with Medical categories.
This book, Natural Products and Cancer Drug Discovery, is written by leading experts in natural products in cancer therapy. The first two sections describe new applications of common herbs and foods for treatment of cancer. Section 3 deals with the development of new chemotherapeutics from Cannabis and endophytic fungi. Section 4 presented formulations of natural products for treatment of malignant melanoma. Made-to-order anticancer therapy from natural products using computational and tissue engineering approaches is addressed in the fifth section. It is our hope that this book may motivate readers to approach the evidence of anticancer natural products with an open mind and thereby spark an interest in making further contributions to the cancer treatment efforts.
New Approaches To Natural Anticancer Drugs
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Author : Soodabeh Saeidnia
language : en
Publisher: Springer
Release Date : 2015-02-05
New Approaches To Natural Anticancer Drugs written by Soodabeh Saeidnia and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-05 with Medical categories.
This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.
Alternative Remedies And Natural Products For Cancer Therapy An Integrative Approach
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Author : Motamarri Venkata Naga Lalitha Chaitanya
language : en
Publisher: Bentham Science Publishers
Release Date : 2023-11-02
Alternative Remedies And Natural Products For Cancer Therapy An Integrative Approach written by Motamarri Venkata Naga Lalitha Chaitanya and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-02 with Medical categories.
This book provides a holistic view of natural products and remedies that have been used to treat cancer. The editors aim to educate readers about the importance of the translational role of natural products in cancer treatment by compiling 14 chapters. The book emphasizes an integrative approach to the topic by blending traditional knowledge that supports alternative therapies with the science of phytochemicals and drug discovery technologies as a means to manage the disease. Key topics include alternative therapies (such as aromatherapy and immune boosting herbal medications), cytotoxic and anti-cancer phytochemicals, drug delivery and discovery technologies (including high-throughput screening) and some drug targets of interest for cancer treatment (such as topoisomerases and caspases). Readers will be able to learn about natural sources of ant-cancer compounds, and the methods used by research and development experts in pharmaceutical and nutraceutical industries to isolate and formulate these compounds. This book will be a handy resource for a wide range of readers. This includes researchers, traditional medical practitioners, PG students, Ph.D. scholars and general readers to understand the role of natural products in cancer treatment. key features - Explains the importance of alternative therapies in the management of cancer - Emphasizes the ethnopharmacological approaches to cancer - Explores natural anticancer drug libraries - Discusses the role of modern cancer targets and the importance of in-silico tools in anticancer drug discovery - Addresses modern drug discovery tools and drug delivery technologies concerning their applications in cancer treatment. - Includes references for further reading
Anticancer Drug Discovery And Development Natural Products And New Molecular Models
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Author : Frederick A. Valeriote
language : en
Publisher: Springer
Release Date : 1994-07-31
Anticancer Drug Discovery And Development Natural Products And New Molecular Models written by Frederick A. Valeriote and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-07-31 with Medical categories.
With the publication of these proceedings from the Second Drug Discovery and Development Symposium, this forum has become the main mechanism for bringing together the principal groups involved in both discovering and developing new approaches to the treatment of cancer. This Second Symposium emphasized the types of materials being discovered and their therapeutic activity. This is especially evident in the natural product discovery programs, where unique and active structures are being identified. The major contributors to the meeting were the investigators participating in the National Cooperative (Natural Products) Drug Discovery Groups [NC(NP)DDG]. These groups reflect an association among researchers at universities or cancer centers, pharmaceutical companies and the National Cancer Institute. Their sources of materials are varied, reflecting chemical inventories of pharmaceutical companies, organic synthetic compounds from the laboratory, cytotoxics as well as biologics and their hybrids, and natural products obtained from plants, marine organisms and microorganisms. The models employed in the discovery systems vary from broadly cellular based to specific enzymes to defined cellular functions. Each of them is believed important to the malignant state and will allow for the discovery of compounds which will have efficacy in cancer therapy. The goal of the participants is both to discover new anticancer agents and to develop them as efficiently as possible into clinically useful additions to treatment. Of importance is the fact that there are a number of promising leads which will soon be moving into the clinic thereby testing the effectiveness of this NC (NP) DDG approach.
Anticancer Agents From Natural Products
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Author : Gordon M. Cragg
language : en
Publisher: CRC Press
Release Date : 2005-06-13
Anticancer Agents From Natural Products written by Gordon M. Cragg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-13 with Medical categories.
Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen
Discovery And Development Of Antidiabetic Agents From Natural Products
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Author : Goutam Brahmachari
language : en
Publisher: Elsevier
Release Date : 2016-10-11
Discovery And Development Of Antidiabetic Agents From Natural Products written by Goutam Brahmachari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-11 with Science categories.
Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab