Discrete And Topological Models In Molecular Biology

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Discrete And Topological Models In Molecular Biology
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Author : Nataša Jonoska
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-23
Discrete And Topological Models In Molecular Biology written by Nataša Jonoska and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-23 with Computers categories.
Theoretical tools and insights from discrete mathematics, theoretical computer science, and topology now play essential roles in our understanding of vital biomolecular processes. The related methods are now employed in various fields of mathematical biology as instruments to "zoom in" on processes at a molecular level. This book contains expository chapters on how contemporary models from discrete mathematics – in domains such as algebra, combinatorics, and graph and knot theories – can provide perspective on biomolecular problems ranging from data analysis, molecular and gene arrangements and structures, and knotted DNA embeddings via spatial graph models to the dynamics and kinetics of molecular interactions. The contributing authors are among the leading scientists in this field and the book is a reference for researchers in mathematics and theoretical computer science who are engaged with modeling molecular and biological phenomena using discrete methods. It may also serve as a guide and supplement for graduate courses in mathematical biology or bioinformatics, introducing nontraditional aspects of mathematical biology.
Models And Modeling In The Sciences
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Author : Stephen M. Downes
language : en
Publisher: Routledge
Release Date : 2020-07-09
Models And Modeling In The Sciences written by Stephen M. Downes and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-09 with Philosophy categories.
Biologists, climate scientists, and economists all rely on models to move their work forward. In this book, Stephen M. Downes explores the use of models in these and other fields to introduce readers to the various philosophical issues that arise in scientific modeling. Readers learn that paying attention to models plays a crucial role in appraising scientific work. This book first presents a wide range of models from a number of different scientific disciplines. After assembling some illustrative examples, Downes demonstrates how models shed light on many perennial issues in philosophy of science and in philosophy in general. Reviewing the range of views on how models represent their targets introduces readers to the key issues in debates on representation, not only in science but in the arts as well. Also, standard epistemological questions are cast in new and interesting ways when readers confront the question, "What makes for a good (or bad) model?" All examples from the sciences and positions in the philosophy of science are presented in an accessible manner. The book is suitable for undergraduates with minimal experience in philosophy and an introductory undergraduate experience in science. Key features: The book serves as a highly accessible philosophical introduction to models and modeling in the sciences, presenting all philosophical and scientific issues in a nontechnical manner. Students and other readers learn to practice philosophy of science by starting with clear examples taken directly from the sciences. While not comprehensive, this book introduces the reader to a wide range of views on key issues in the philosophy of science.
Recombinatorics
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Author : Dan Gusfield
language : en
Publisher: MIT Press
Release Date : 2014-07-03
Recombinatorics written by Dan Gusfield and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-03 with Mathematics categories.
When a Philadelphia girl intercepts a message about an impending British attack against her father's regiment, commanded by General Washington, in White Marsh, she travels alone by horseback to warn the Patriot army.
The Topological Model Of Genome And Evolution
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Author : Pradeep Chhaya
language : en
Publisher: Springer Nature
Release Date : 2023-09-19
The Topological Model Of Genome And Evolution written by Pradeep Chhaya and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-19 with Science categories.
This book deals with the missing link in the domain of functional genomics viz. genomic architecture. It begins with a deconstruction of the Darwinian paradigm using the proposed model of modified involuted manifolds. It recasts the process of natural selection as a process of information transfer. Using a topological model, this book outlines a new genomic architecture. The key argument for this proposed model is that some such structuralism has always been implicit in genomics. The proposed model fits very well with the known genomic characteristics and allows to separate the regulatory genome from the transcriptive genomes. The model is capable of discerning modular architecture of genomes with different genomic functionalities existing in hierarchical relationships and demonstrates that genomes act as units of selection and as the environment for the individual genes which act as competing species. Towards the end, the book also examines the role of genomic evolution in cancer and the principles of natural selection and evolution of the genotype. The regulatory genome is also discussed, with an emphasis on its evolution and natural selection. It is a valuable source for researchers working in functional genomics, mathematical modeling in biology and evolutionary genomics.
Algebraic And Combinatorial Computational Biology
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Author : Raina Robeva
language : en
Publisher: Academic Press
Release Date : 2018-10-08
Algebraic And Combinatorial Computational Biology written by Raina Robeva and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-08 with Mathematics categories.
Algebraic and Combinatorial Computational Biology introduces students and researchers to a panorama of powerful and current methods for mathematical problem-solving in modern computational biology. Presented in a modular format, each topic introduces the biological foundations of the field, covers specialized mathematical theory, and concludes by highlighting connections with ongoing research, particularly open questions. The work addresses problems from gene regulation, neuroscience, phylogenetics, molecular networks, assembly and folding of biomolecular structures, and the use of clustering methods in biology. A number of these chapters are surveys of new topics that have not been previously compiled into one unified source. These topics were selected because they highlight the use of technique from algebra and combinatorics that are becoming mainstream in the life sciences. - Integrates a comprehensive selection of tools from computational biology into educational or research programs - Emphasizes practical problem-solving through multiple exercises, projects and spinoff computational simulations - Contains scalable material for use in undergraduate and graduate-level classes and research projects - Introduces the reader to freely-available professional software - Supported by illustrative datasets and adaptable computer code
Emerging Trends In Applications And Infrastructures For Computational Biology Bioinformatics And Systems Biology
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Author : Hamid R Arabnia
language : en
Publisher: Morgan Kaufmann
Release Date : 2016-03-25
Emerging Trends In Applications And Infrastructures For Computational Biology Bioinformatics And Systems Biology written by Hamid R Arabnia and has been published by Morgan Kaufmann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-25 with Computers categories.
Emerging Trends in Applications and Infrastructures for Computational Biology, Bioinformatics, and Systems Biology: Systems and Applications covers the latest trends in the field with special emphasis on their applications. The first part covers the major areas of computational biology, development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques for the study of biological and behavioral systems. The second part covers bioinformatics, an interdisciplinary field concerned with methods for storing, retrieving, organizing, and analyzing biological data. The book also explores the software tools used to generate useful biological knowledge. The third part, on systems biology, explores how to obtain, integrate, and analyze complex datasets from multiple experimental sources using interdisciplinary tools and techniques, with the final section focusing on big data and the collection of datasets so large and complex that it becomes difficult to process using conventional database management systems or traditional data processing applications. - Explores all the latest advances in this fast-developing field from an applied perspective - Provides the only coherent and comprehensive treatment of the subject available - Covers the algorithm development, software design, and database applications that have been developed to foster research
Logical Modeling Of Cellular Processes From Software Development To Network Dynamics
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Author : Matteo Barberis
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-16
Logical Modeling Of Cellular Processes From Software Development To Network Dynamics written by Matteo Barberis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with categories.
Mathematical models have become invaluable tools for understanding the intricate dynamic behavior of complex biochemical and biological systems. Among computational strategies, logical modeling has been recently gaining interest as an alternative approach to address network dynamics. Due to its advantages, including scalability and independence of kinetic parameters, the logical modeling framework is becoming increasingly popular to study the dynamics of highly interconnected systems, such as cell cycle progression, T cell differentiation and gene regulation. Novel tools and standards have been developed to increase the interoperability of logical models, which can now be employ to respond a variety of biological questions. This Research Topic brings together the most recent and cutting-edge approaches in the area of logical modeling including, among others, novel biological applications, software development and model analysis techniques.
Combinatorics Graph Theory And Computing
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Author : Sarah Heuss
language : en
Publisher: Springer Nature
Release Date : 2024-11-26
Combinatorics Graph Theory And Computing written by Sarah Heuss and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-26 with Mathematics categories.
This proceedings volume compiles selected, revised papers presented at the 53rd SouthEastern International Conference on Combinatorics, Graph Theory, and Computing (SEICCGTC 2022), which took place at Florida Atlantic University in Boca Raton, USA, from March 7th to 11th, 2022. The SEICCGTC is widely regarded as a trendsetter for other conferences worldwide. Many ideas and themes initially discussed here have subsequently been explored in other conferences and symposia. Since 1970, the conference has been held annually in Baton Rouge, Louisiana, and Boca Raton, Florida. Over the years, it has grown to become the primary annual conference in its fields, playing a crucial role in disseminating results and fostering collaborative work. This volume is tailored for the community of pure and applied mathematicians in academia, industry, and government, who work in combinatorics and graph theory, as well as related areas of computer science and the intersections among these fields.
Integer Linear Programming In Computational And Systems Biology
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Author : Dan Gusfield
language : en
Publisher: Cambridge University Press
Release Date : 2019-06-13
Integer Linear Programming In Computational And Systems Biology written by Dan Gusfield and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-13 with Computers categories.
This hands-on tutorial text for non-experts demonstrates biological applications of a versatile modeling and optimization technique.
Combinatorics Graph Theory And Computing
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Author : Frederick Hoffman
language : en
Publisher: Springer Nature
Release Date : 2024-06-15
Combinatorics Graph Theory And Computing written by Frederick Hoffman and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-15 with Mathematics categories.
This proceedings volume convenes selected, revised papers presented at the 52nd Southeastern International Conference on Combinatorics, Graph Theory and Computing (SEICCGTC 2021), virtually held at Florida Atlantic University in Boca Raton, USA, on March 8-12, 2021. As has been a tradition since its inception in 1970, this edition once more brought together mathematicians, practitioners, and scientists around novel findings in combinatorics, graph theory and computing, and their interactions. The lectures and works presented at the Conference have proven to be of great interest to other scientists and analysts employing these mathematical sciences in their professional activities in business, industry, and government. Such an environment promotes a better understanding of the roles of modern applied mathematics, combinatorics, and computer science. Many works have demonstrated that disciplines have increasingly contributed to each other. With this series of Conferences, the gaps between the fields tend to decrease even further. This volume is of particular interest for the community of pure and applied mathematicians in academia, industry, and government, working in combinatorics and graph theory, as well as related areas of computer science and the interactions among these fields. Its findings can also benefit a general audience of practitioners and students from related fields.