The Topological Model Of Genome And Evolution
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The Topological Model Of Genome And Evolution
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Author : Pradeep Chhaya
language : en
Publisher: Springer Nature
Release Date :
The Topological Model Of Genome And Evolution written by Pradeep Chhaya and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Topological Data Analysis For Genomics And Evolution
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Author : Raul Rabadan
language : en
Publisher: Cambridge University Press
Release Date : 2019-12-19
Topological Data Analysis For Genomics And Evolution written by Raul Rabadan and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-19 with Science categories.
An introduction to geometric and topological methods to analyze large scale biological data; includes statistics and genomic applications.
Genome Evolution
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Author : Axel Meyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-28
Genome Evolution written by Axel Meyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-28 with Science categories.
In the years since the publication of Susumu Ohno's 1970 landmark book Evolution by gene duplication tremendous advances have been made in molecular biology and especially in genomics. Studies of genome structure and function prerequisite to testing hypotheses of genome evolution were all but impossible until recent methodological advances. This book evaluates newly generated empirical evidence as it pertains to theories of genomic evolutionary patterns and processes. Tests of hypotheses using analyses of complete genomes, interpreted in a phylogenetic context, provide evidence regarding the relative importance of gene duplication. The alternative explanation is that the evolution of regulatory elements that control the expression of and interactions among genes has been a more important force in shaping evolutionary innovation. This collection of papers will be of interest to all academic and industry researchers working in the fields of molecular biology, biotechnology, genomics and genome centers.
Models And Algorithms For Genome Evolution
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Author : Cedric Chauve
language : en
Publisher: Springer
Release Date : 2016-09-27
Models And Algorithms For Genome Evolution written by Cedric Chauve and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-27 with Computers categories.
This authoritative text/reference presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data. These viewpoints build upon the pioneering work of David Sankoff, one of the founding fathers of computational biology, and mark the 50th anniversary of his first scientific article. The broad spectrum of rich contributions in this essential collection will appeal to all computer scientists, mathematicians and biologists involved in comparative genomics, phylogenetics and related areas.
Structural And Evolutionary Genomics
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Author : Giorgio Bernardi
language : en
Publisher: Elsevier
Release Date : 2005-12-19
Structural And Evolutionary Genomics written by Giorgio Bernardi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-19 with Science categories.
Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a "regional" control is exerted by natural selection (essentially negative or purifying selection). A "neo-selectionist" model is proposed for genome evolution. · Summarizes the existing knowledge on genome organization and evolution in a self-contained book · Discusses important open problem, without refraining from criticism whenever appropriate
Gene Genealogies Variation And Evolution A Primer In Coalescent Theory
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Author : Jotun Hein
language : en
Publisher: Oxford University Press, USA
Release Date : 2004-12-09
Gene Genealogies Variation And Evolution A Primer In Coalescent Theory written by Jotun Hein and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-09 with Population genetics categories.
Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. - Professor Montgomery Slatkin (Berkeley);the authors are outstanding experts in the field, and the book is topical and timely. - Professor David Balding (Imperial College);Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. - Professor Joe Felsenstein (University of Washington)
Structural Approaches To Sequence Evolution
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Author : Ugo Bastolla
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-26
Structural Approaches To Sequence Evolution written by Ugo Bastolla and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-26 with Science categories.
Recent advances in understanding the thermodynamics of macromolecules, the topological properties of gene networks, the organization and mutation capabilities of genomes, and the structure of populations make it possible to incorporate these key elements into a broader and deeply interdisciplinary view of molecular evolution. This book gives an account of such a new approach, through clear tutorial contributions by leading scientists.
Evolutionary Genomics And Systems Biology
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Author : Gustavo Caetano-Anoll¿s
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-26
Evolutionary Genomics And Systems Biology written by Gustavo Caetano-Anoll¿s and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-26 with Science categories.
A comprehensive, authoritative look at an emergent area in post-genomic science, Evolutionary genomics is an up-and-coming, complex field that attempts to explain the biocomplexity of the living world. Evolutionary Genomics and Systems Biology is the first full-length book to blend established and emerging concepts in bioinformatics, evolution, genomics, and structural biology, with the integrative views of network and systems biology. Three key aspects of evolutionary genomics and systems biology are covered in clear detail: the study of genomic history, i.e., understanding organismal evolution at the genomic level; the study of macromolecular complements, which encompasses the evolution of the protein and RNA machinery that propels life; and the evolutionary and dynamic study of wiring diagrams—macromolecular components in interaction—in the context of genomic complements. The book also features: A solid, comprehensive treatment of phylogenomics, the evolution of genomes, and the evolution of biological networks, within the framework of systems biology A special section on RNA biology—translation, evolution of structure, and micro RNA and regulation of gene expression Chapters on the mapping of genotypes to phenotypes, the role of information in biology, protein architecture and biological function, chromosomal rearrangements, and biological networks and disease Contributions by leading authorities on each topic Evolutionary Genomics and Systems Biology is an ideal book for students and professionals in genomics, bioinformatics, evolution, structural biology, complexity, origins of life, systematic biology, and organismal diversity, as well as those individuals interested in aspects of biological sciences as they interface with chemistry, physics, and computer science and engineering.
Discrete And Topological Models In Molecular Biology
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Author : Nataša Jonoska
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-23
Discrete And Topological Models In Molecular Biology written by Nataša Jonoska and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-23 with Computers categories.
Theoretical tools and insights from discrete mathematics, theoretical computer science, and topology now play essential roles in our understanding of vital biomolecular processes. The related methods are now employed in various fields of mathematical biology as instruments to "zoom in" on processes at a molecular level. This book contains expository chapters on how contemporary models from discrete mathematics – in domains such as algebra, combinatorics, and graph and knot theories – can provide perspective on biomolecular problems ranging from data analysis, molecular and gene arrangements and structures, and knotted DNA embeddings via spatial graph models to the dynamics and kinetics of molecular interactions. The contributing authors are among the leading scientists in this field and the book is a reference for researchers in mathematics and theoretical computer science who are engaged with modeling molecular and biological phenomena using discrete methods. It may also serve as a guide and supplement for graduate courses in mathematical biology or bioinformatics, introducing nontraditional aspects of mathematical biology.
Molecular Systematics And Evolution Theory And Practice
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Author : R. DeSalle
language : en
Publisher: Birkhäuser
Release Date : 2013-03-08
Molecular Systematics And Evolution Theory And Practice written by R. DeSalle and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Science categories.
Important practical implications are established by case reports and specific examples. The present book is the ideal complement to the practitioner’s manual Techniques in Molecular Systematics and Evolution, recently published by the same editors in the Birkhäuser MTBM book series. The first part of this book deals with important applications of evolutionary and systematic analysis at different taxonomic levels. The second part discusses DNA multiple sequence alignment, species designations using molecular data, evo-devo and other topics that are problematic or controversial. In the last part, novel topics in molecular evolution and systematics, like genomics, comparative methods in molecular evolution and the use of large data bases are described. The final chapter deals with problems in bacterial evolution, considering the increasing access to large numbers of complete genome sequences.