Dopaminergic System Function And Dysfunction Experimental Approaches
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Dopaminergic System Function And Dysfunction Experimental Approaches
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Author : José Antonio Fuentealba-Evans
language : en
Publisher: Springer Nature
Release Date : 2022-12-07
Dopaminergic System Function And Dysfunction Experimental Approaches written by José Antonio Fuentealba-Evans and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-07 with Medical categories.
This volume provides a variety of technical approaches to study dopamine system function and dysfunction. Chapters guide readers through dopamine release in ex vivo and freely moving animals, multi-recording devices for in vivo simultaneous single cell and population activity, in silico modeling of dopamine neurons activity, neuroanatomical approaches, unbiased stereology, ultrastructural analyses of dopaminergic neurons, and axonal innervation. Additionally, chapters also incorporate pharmacological tools to model neuropsychiatric diseases, novel behavioral paradigms to dissect dopamine's role in behavior, and functional imaging to follow human dopamine system development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Dopamine Neurotransmission aims to be a valuable resource for researchers in various disciplines.
Central Nervous System Diseases
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Author : Dwaine F. Emerich
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-11-24
Central Nervous System Diseases written by Dwaine F. Emerich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-24 with Medical categories.
Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
Development And Engineering Of Dopamine Neurons
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Author : Jeroen Pasterkamp
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-16
Development And Engineering Of Dopamine Neurons written by Jeroen Pasterkamp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-16 with Medical categories.
Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.
Neuronal Networks In Brain Function Cns Disorders And Therapeutics
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Author : Carl Faingold
language : en
Publisher: Academic Press
Release Date : 2013-12-26
Neuronal Networks In Brain Function Cns Disorders And Therapeutics written by Carl Faingold and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-26 with Medical categories.
Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
Attention In Cognitive Systems Theories And Systems From An Interdisciplinary Viewpoint
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Author : Lucas Paletta
language : en
Publisher: Springer
Release Date : 2007-12-03
Attention In Cognitive Systems Theories And Systems From An Interdisciplinary Viewpoint written by Lucas Paletta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-03 with Computers categories.
This volume provides a much-needed interdisciplinary angle on the subject of attention in cognitive systems. It constitutes the thoroughly refereed post-workshop proceedings of the 5th International Workshop on Attention in Cognitive Systems, held in Hyderabad, India, in January 2007. The 31 papers are organized in topical sections that cover every aspect of the subject, from the embodiment of attention and its cognitive control, to the applications of attentive vision.
Imaging Of The Human Brain In Health And Disease
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Author : Philip Seeman
language : en
Publisher: Elsevier
Release Date : 2013-11-15
Imaging Of The Human Brain In Health And Disease written by Philip Seeman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-15 with Science categories.
Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. A focused introduction to imaging healthy and diseased brains Focuses on the primary neurotransmitter release Includes sigma, acetylcholine, opioid, and dopamine receptors Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease
Improving And Accelerating Therapeutic Development For Nervous System Disorders
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2014-02-06
Improving And Accelerating Therapeutic Development For Nervous System Disorders written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-06 with Medical categories.
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
The Basal Ganglia
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Author : Jean-Jacques Soghomonian
language : en
Publisher: Springer
Release Date : 2016-11-04
The Basal Ganglia written by Jean-Jacques Soghomonian and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-04 with Psychology categories.
This groundbreaking text takes current knowledge of the basal ganglia far from well-known motor-based models to a more inclusive understanding of deep-brain structure and function. Synthesizing diverse perspectives from across the brain-behavioral sciences, it tours the neuroanatomy and circuitry of the basal ganglia, linking their organization to their controlling functions in core cognitive, behavioral, and motor areas, both normative and disordered. Interactions between the basal ganglia and major structures of the brain are identified in their contributions to a diverse range of processes, from language processing to decision-making, emotion to visual perception, motivation to intent. And the basal ganglia are intimately involved in the mechanisms of dysfunction, as evinced by chapters on dyskinesia, Parkinson’s disease, neuropsychiatric conditions, and addictions. Included in the coverage: Limbic-basal ganglia circuits: parallel and integrative aspects. Dopamine and its actions in the basal ganglia system. Cerebellar-basal ganglia interactions. The basal ganglia contribution to controlled and automatic processing. The basal ganglia and decision making in neuropsychiatric disorders. The circuitry underlying the reinstatement of cocaine seeking: modulation by deep brain stimulation. The basal ganglia and hierarchical control in voluntary behavior. Its breadth and depth of scholarship and data should make The Basal Ganglia a work of great interest to cognitive psychologists and neuroscientists, neuropsychologists, neurologists, neuropsychiatrists, and speech-language pathologists.
Catecholamines Bridging Basic Science With Clinical Medicine
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Author :
language : en
Publisher: Academic Press
Release Date : 1997-10-20
Catecholamines Bridging Basic Science With Clinical Medicine written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-20 with Medical categories.
This volume in Advances in Pharmacology focuses on all aspects of catecholamine research, from very basic to medical. It is broad based and covers many areas within physiology and medicine.
Imaging Dopamine
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Author : Paul Cumming
language : en
Publisher: Cambridge University Press
Release Date : 2009-04-02
Imaging Dopamine written by Paul Cumming and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-02 with Medical categories.
An illustrated biography of the dopamine molecule, with each chapter presenting a specific stage in the biochemical pathway for dopamine.