Dynamic Biomarkers Of Response To Anti Immune Checkpoint Inhibitors In Cancer
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Dynamic Biomarkers Of Response To Anti Immune Checkpoint Inhibitors In Cancer
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Author : Said Dermime
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-28
Dynamic Biomarkers Of Response To Anti Immune Checkpoint Inhibitors In Cancer written by Said Dermime and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-28 with Medical categories.
Novel Biomarkers In Tumor Immunity And Immunotherapy
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Author : Takaji Matsutani
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-26
Novel Biomarkers In Tumor Immunity And Immunotherapy written by Takaji Matsutani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-26 with Science categories.
Immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies are highly effective against many types of cancer, yet durable responses are limited to a subset of patients highlighting the need for the development of effective biomarkers to predict prognosis and efficacy. Currently, PD-L1 expression in tumors, microsatellite instability (MSI) or mismatch repair deficiency (dMMR), and tumor mutation burden (TMB) are known as biomarkers for cancer immunotherapy but are not sufficient. Combination therapy with immune checkpoint inhibitors and chemotherapy or radiation therapy, as well as diverse therapies targeting intra-tumoral regulatory T cells have been described, but there are currently no unifying biomarkers that are applicable to clinically, a simple, fast, non-invasive method that can yield biomarkers of disease with a minimal adverse effect on patients is desirable. Recent findings suggest that the balancing of effector T cells and regulatory cells in the tumor microenvironment is associated with cancer progression and prognosis. Cells and molecules involved in the control of cancer are complex, and a better understanding of the tumor immune environment will lead to the development of truly effective biomarkers. This topic will focus on novel biomarkers that predict efficacy, prognosis, or the development of adverse events in various cancer immunotherapies, and extensive basic research leading to the development of biomarkers. Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic. We expect a wide range of research, not only in serology, genetics, and immunocytochemistry but also in bacterial flora. Research on the development of novel assays and bioinformatics methods is also welcome: • Non-invasive biomarkers for cancer immunotherapy. • Bulk RNA-seq, scRNA-seq, or Rep-seq methods. • Correlation of tumor immune cells with gut microbiota in tumor immunotherapy. • Impact of Teff and Treg balance in the tumor microenvironment on tumor prognosis. • Inflammatory and immune signatures associated with drug response versus resistance in cancer.
Immunotherapy Of Hepatocellular Carcinoma
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Author : Tim F. Greten
language : en
Publisher: Springer
Release Date : 2018-08-22
Immunotherapy Of Hepatocellular Carcinoma written by Tim F. Greten and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-22 with Medical categories.
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Oncoimmunology
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Author : Laurence Zitvogel
language : en
Publisher: Springer
Release Date : 2017-12-13
Oncoimmunology written by Laurence Zitvogel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-13 with Medical categories.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Cutaneous Melanoma
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Author :
language : en
Publisher:
Release Date :
Cutaneous Melanoma written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Advances In Precision Medicine Oncology
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Author : Hilal Arnouk
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-07-21
Advances In Precision Medicine Oncology written by Hilal Arnouk and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-21 with Medical categories.
Recent advances in precision medicine and immuno-oncology have led to highly specific and efficacious cancer therapies such as monoclonal antibodies and immune checkpoint inhibitors (ICIs). This book provides an up-to-date overview of advances in the field of immuno-oncology. Chapters cover such topics as ICIs and how they mount a robust immune response against cancer cells as well as the response of ICIs to treatment predictive biomarkers and their potential immune-related adverse events (irAEs). Additionally, the book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin’s drug resistance and critical side effects.
Critical Developments In Cancer Immunotherapy
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Author : Sheykhhasan, Mohsen
language : en
Publisher: IGI Global
Release Date : 2024-08-28
Critical Developments In Cancer Immunotherapy written by Sheykhhasan, Mohsen and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-28 with Medical categories.
Cancer still poses a significant challenge in healthcare since traditional treatments often fail to produce desired results and patient outcomes. Conventional therapies, like chemotherapy and radiation, can have substantial side effects and may not always be able to eliminate cancer cells. Moreover, the heterogeneity of tumors and individual responses to treatment create barriers to achieving consistent and long-lasting outcomes. Critical Developments in Cancer Immunotherapy offers a compelling solution to these challenges by delving into the cutting-edge field of cancer immunotherapy. This book provides a comprehensive guide to the latest advancements in harnessing the body's immune system to fight cancer. Focusing on critical strategies like checkpoint inhibitors and CAR T-cell therapy, the book provides insights into novel approaches that offer greater precision and effectiveness in cancer treatment.
Understanding The Immuno Oncological Mechanism Of Cancer Using Systems Immunology Approaches
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Author : Rifat Hamoudi
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-02
Understanding The Immuno Oncological Mechanism Of Cancer Using Systems Immunology Approaches written by Rifat Hamoudi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-02 with Medical categories.
Novel Biomarkers For Predicting Response To Cancer Immunotherapy
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Author : Jinghua Pan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-11
Novel Biomarkers For Predicting Response To Cancer Immunotherapy written by Jinghua Pan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-11 with Medical categories.
Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, relevant predictors of cancer immunotherapy response include microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR), expression of PD-L1, tumor mutation burden (TMB), immune genomic characteristics, and tumor infiltrating lymphocytes (TILs). However, none of them have sufficient evidence to be a stratification factor. Moreover, as the combined strategies for effective cancer immunotherapy had been developed in multiple tumors, such as Immunotherapy combined with chemotherapy, radiotherapy, targeted therapy and anti-angiogenesis therapy. Therefore, the development of novel biomarkers endowed with high sensitivity, specificity and accuracy able to identify which patients may truly benefit from the treatment with cancer immunotherapy would allow to refine the therapeutic selection and to better tailor the treatment strategy.
Melanoma In Clinical Practice
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Author : Rhoda M. Alani
language : en
Publisher: Springer Nature
Release Date : 2021-11-26
Melanoma In Clinical Practice written by Rhoda M. Alani and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
This book provides a concise practical guide to melanoma enabling the reader to develop a thorough understanding of the etiology, pathogenesis, diagnosis, treatment and prevention of melanoma. It features easy to digest instructional text that describes a variety of techniques for detecting and staging melanoma including total body photography. Surgical, radiation and systemic therapy treatment options as well as prevention strategies are also covered. Melanoma in Clinical Practice represents a thorough guide on how to diagnose treat and prevent melanoma, and provides a valuable resource for the trainee and experienced clinical dermatologists who are seeking a reference guide to use in their clinical practice.