Dynamics Of Immune Activation In Viral Diseases
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Dynamics Of Immune Activation In Viral Diseases
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Author : Pallaval Veera Bramhachari
language : en
Publisher: Springer Nature
Release Date : 2020-02-24
Dynamics Of Immune Activation In Viral Diseases written by Pallaval Veera Bramhachari and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-24 with Medical categories.
This book discusses various components of the innate and adaptive immune response in combating viral infections, presenting the recent advances in our understanding of innate immunity recognition of viruses and highlighting the important role of inflammation, cytokines such as interferon, toll-like receptors and leukocytes in the initial detection of invading viruses and subsequent activation of adaptive immunity. It also summarizes the role of the adaptive immunity against viral infections through clearance of virus and establishment of memory response that protects against the recurrent infections. In addition, the book examines the role of DNA and RNA sensors in viral recognition and in controlling viral infection. Lastly, it reviews the latest developments in the development of the rational viral vaccines. As such it is a useful resource book for postgraduate and early researchers wanting to gain insights into the immune response to viral infections.
Virus Dynamics Mathematical Principles Of Immunology And Virology
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Author : Martin Nowak
language : en
Publisher: Oxford University Press, UK
Release Date : 2000-11-23
Virus Dynamics Mathematical Principles Of Immunology And Virology written by Martin Nowak and has been published by Oxford University Press, UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-23 with categories.
This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature
Virus Dynamics
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Author : Martin A. Nowak
language : en
Publisher: Oxford University Press
Release Date : 2000-11-23
Virus Dynamics written by Martin A. Nowak and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-23 with Mathematics categories.
This text describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals insights into the dynamics of viral & other infections.
The Immune Response To Viral Infections
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Author : B.A. Askonas
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Immune Response To Viral Infections written by B.A. Askonas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Virus diseases continue to represent serious health problems in most parts of the world. In spite of the fact that diseases such as polio myelitis and measles have been controlled in the industrialized countries by vaccination, vaccines now in use in tropical countries have proved not to be optimal. Further research is needed to develop new vaccines that will be effective in all countries. To do so we need to understand better the immune response to different viruses so that we may be able to maxi mize the protective response of new vaccines and minimize their potential immunopathologic effect. An exciting new discovery which is now being further developed is the possibility of being able to use some viruses (e.g. vaccinia, adenoviruses, etc.), as carriers for other antigens. This may open up the way for the production of vaccines that will be inexpensive and that will confer long lasting immunity after only one injection. This meeting has also served to review our present knowledge of virus diseases which are still of great importance such as hepatitis, dengue and influenza.
Killer Cell Dynamics
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Author : Dominik Wodarz
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-04-05
Killer Cell Dynamics written by Dominik Wodarz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-05 with Mathematics categories.
This book reviews how mathematical and computational approaches can be useful to help us understand how killer T-cell responses work to fight viral infections. It also demonstrates, in a writing style that exemplifies the point, that such mathematical and computational approaches are most valuable when coupled with experimental work through interdisciplinary collaborations. Designed to be useful to immunoligists and viroligists without extensive computational background, the book covers a broad variety of topics, including both basic immunological questions and the application of these insights to the understanding and treatment of pathogenic human diseases.
Viral Pathogenesis And Immunity
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Author : Neal Nathanson
language : en
Publisher:
Release Date : 2002
Viral Pathogenesis And Immunity written by Neal Nathanson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
This text provides a coherent and concise introduction to the field of viral pathogenesis and immunity. The text is divided into four sections which highlight the fundamental principles within this field of study. Section 1, Essentials of Viral Pathogenesis, describes the sequential events in viral infection, the localization of viral infections and the variety of virus-cell interactions. Section 2, Host Responses to Viral Infection, examines immune responses including virus-induced immunopathology and immunosuppression. Section 3, Virus-Host Interactions, covers virulence, viral persistence, virus-induced oncogenesis and host susceptibility. Section 4, Prevention of Viral Infections, explains the key principles of vaccine development.
Mechanisms Of Lymphocyte Activation And Immune Regulation Vii
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Author : Sudhir Gupta
language : en
Publisher: Springer
Release Date : 2012-10-23
Mechanisms Of Lymphocyte Activation And Immune Regulation Vii written by Sudhir Gupta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-23 with Medical categories.
Proceedings of the Seventh International Conference held in New Port Beach, California, February 6-8, 1998
Immunopathogenesis Of Hiv Infection
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Author : Anthony S. Fauci
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunopathogenesis Of Hiv Infection written by Anthony S. Fauci and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.
Persistent Viral Infections
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Author : R. Ahmed
language : en
Publisher: Wiley-Blackwell
Release Date : 1999
Persistent Viral Infections written by R. Ahmed and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.
Virus Induced Immunosuppression
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Author : Steven Specter
language : en
Publisher: Springer
Release Date : 1989-01-31
Virus Induced Immunosuppression written by Steven Specter and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-01-31 with Medical categories.
It is now widely acknowledged that at the beginning of this century Claude von Pirquet first pointed out that a viral disease, i. e. , measles, resulted in an anergy or depression of preexisting immune response, namely, delayed continuous hypersensitivity to PPD derived from Mycobacterium tuberculosis. Thereafter ob servations that viral infections may result in immunosuppression have been recorded by many clinicians and infectious disease investigators for six or seven decades. Nevertheless, despite sporadic reports that infectious diseases caused by viruses may result in either transient or prolonged immunodepression, investigation of this phenomenon languished until the mid-1960s, when it was pointed out that a number of experimental retroviral infections of mice with tumor viruses may result in marked immunosuppression. However, it was not until the recognition of the new epidemic of acquired immunodeficiency syn drome (AIDS) caused by the human immunodeficiency virus and related vi ruses that acquired immunodeficiencies associated with virus infection became general knowledge among biomedical investigators as well as the lay public. A number of reviews published during the past decade or so pointed out that numerous viruses may affect humoral and cellular immune responses. Furthermore, expanding knowledge about the nature and mechanisms of both humoral and cellular immunity and pathogenesis of viral infections has pro vided clinical and experimental models for investigating in depth how and why viruses of man and animals profoundly affect immune responses.