Early Vascular Aging Eva
DOWNLOAD
Download Early Vascular Aging Eva PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Early Vascular Aging Eva book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Early Vascular Aging Eva
DOWNLOAD
Author : Pedro Guimarães Cunha
language : en
Publisher: Elsevier
Release Date : 2024-02-29
Early Vascular Aging Eva written by Pedro Guimarães Cunha and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-29 with Medical categories.
Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA. Contains all the relevant information available on the main paradigm shifts in vascular aging research, from different fields of knowledge (from basic biology to epidemiology) Reviews the most prominent evidence produced on early vascular aging (EVA), highlighting recent research advances, clinical applications, and research opportunities Formulates, in each chapter, a set of research questions that need to be addressed, challenging the vast research community to take on new directions and collaborations
Determinants And Impact Of Early Vascular Aging In Children And Adolescents
DOWNLOAD
Author : Ruan Kruger
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-26
Determinants And Impact Of Early Vascular Aging In Children And Adolescents written by Ruan Kruger and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-26 with Medical categories.
Vascular Aging Facts And Factors
DOWNLOAD
Author : Elisabet Vila
language : en
Publisher: Frontiers E-books
Release Date :
Vascular Aging Facts And Factors written by Elisabet Vila and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
The increasing mean age of the population in developed countries has turned out to be an economic and social problem. Cardiovascular disease has long been considered to be age related in terms of their onset and progression. As such, we can say that the increase in life expectancy goes in parallel with increased incidence of cardiovascular disease. With age, a number of changes occur in the vasculature altering the homeostasis of the irrigated organs promoting target organ damage. While different adaptive mechanisms to protect vessels against mild stress have been described, the aging process induces a progressive failure of protective mechanisms, leading to vascular changes and higher susceptibility to cardiovascular diseases. Indeed, vascular aging is exacerbated by coexisting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Compelling evidence indicates that diminished endothelial relaxation and increase, decrease, or no change in contractile responses to several agonists is associated with aging. There is an increase of vasoconstrictor factors expression and a decrease of vasodilators. Morphologic changes include lumen diameter enlargement, wall thickening and alterations of matrix substances as increased collagen or decreased elastin deposition, ultimately leading to greater arterial stiffening (reduced compliance). Importantly, arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Cellular and molecular mechanisms have also been documented. Senescence at the cellular level involves alterations in Ca2+ signaling and down regulation of anti-aging proteins. Both endothelial and smooth muscle cells change their number, morphology, function and their regenerative ability. Aging is also associated with a gradual loss of antioxidant defense mechanisms, a proinflammatory shift in the cytokine expression profile and a production of reactive oxygen species such as superoxide (O2-) that promotes the breakdown of nitric oxide. Nitric oxide and O2- interact to form peroxynitrite known to nitrosylate proteins affecting their physiological function. However, vascular wall proteins may also suffer from other potentially deleterious modifications as glycation (Maillard reaction) and glyco-oxidative reactions with increasing age, which could be linked to the age-associated changes in vascular function. Various strategies have shown benefit in preventing, delaying or attenuating vascular aging. For instance, a healthy lifestyle including low fat diet and/or exercise have a favorable effect. Nevertheless, it yet remains to be fully demonstrated whether vascular aging can be pharmacologically prevented. This Research Topic is intended to bring together research efforts to understand the causes and consequences of vascular aging and propose new therapeutic strategies for the management of vascular senescence.
Textbook Of Vascular Medicine
DOWNLOAD
Author : Rhian M. Touyz
language : en
Publisher: Springer
Release Date : 2019-08-02
Textbook Of Vascular Medicine written by Rhian M. Touyz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-02 with Medical categories.
This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Photoplethysmography
DOWNLOAD
Author : Panicos A. Kyriacou
language : en
Publisher: Academic Press
Release Date : 2021-11-03
Photoplethysmography written by Panicos A. Kyriacou and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-03 with Technology & Engineering categories.
Photoplethysmography: Technology, Signal Analysis, and Applications is the first comprehensive volume on the theory, principles, and technology (sensors and electronics) of photoplethysmography (PPG). It provides a detailed description of the current state-of-the-art technologies/optical components enabling the extreme miniaturization of such sensors, as well as comprehensive coverage of PPG signal analysis techniques including machine learning and artificial intelligence. The book also outlines the huge range of PPG applications in healthcare, with a strong focus on the contribution of PPG in wearable sensors and PPG for cardiovascular assessment. Presents the underlying principles and technology surrounding PPG Includes applications for healthcare and wellbeing Focuses on PPG in wearable sensors and devices Presents advanced signal analysis techniques Includes cutting-edge research, applications and future directions
Basic Sciences For Mcem
DOWNLOAD
Author : Chetan Trivedy
language : en
Publisher: CRC Press
Release Date : 2016-05-15
Basic Sciences For Mcem written by Chetan Trivedy and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-15 with Medical categories.
This book is a dedicated resource for those sitting the Part A of the MCEM (Membership of the College of Emergency Medicine) examination. It forms an essential revision guide for emergency trainees who need to acquire a broad understanding of the basic sciences, which underpin their approach to clinical problems in the emergency department. Common clinical scenarios are used to highlight the essential underlying basic science principles, providing a link between clinical management and a knowledge of the underlying anatomical, physiological, pathological and biochemical processes. Multiple choice questions with reasoned answers are used to confirm the candidates understanding and for self testing. Unlike other recent revision books which provide MCQ questions with extended answers, this book uses clinical cases linked to the most recent basic science aspects of the CEM syllabus to provide a book that not only serves as a useful revision resource for the Part A component of the MCEM examination, but also a unique way of understanding the processes underlying common clinical cases seen every day in the emergency department. This book is essential for trainees sitting the Part A of the MCEM exam and for clinicians and medical students who need to refresh their knowledge of basic sciences relevant to the management of clinical emergencies.
Circadian Rhythms And Their Impact On Aging
DOWNLOAD
Author : S. Michal Jazwinski
language : en
Publisher: Springer
Release Date : 2017-10-24
Circadian Rhythms And Their Impact On Aging written by S. Michal Jazwinski and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-24 with Medical categories.
Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.
The Better Brain Book
DOWNLOAD
Author : David Perlmutter
language : en
Publisher: Penguin
Release Date : 2005-08-02
The Better Brain Book written by David Perlmutter and has been published by Penguin this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-02 with Self-Help categories.
From the author of the #1 New York Times bestseller Grain Brain and New York Times bestseller Brain Maker... Loss of memory is not a natural part of aging—and this book explains why. Celebrated neurologist David Perlmutter reveals how everyday memory-loss—misplacing car keys, forgetting a name, losing concentration in meetings—is actually a warning sign of a distressed brain. Here he and Carol Colman offer a simple plan for repairing those problems, clarifying misconstrued connections between memory loss and aging, and regaining and maintaining mental clarity by offering the tools for: Building a better brain through nutrition, lifestyle changes, and brain workouts Coping with specific brain disorders such as stroke, vascular dementia, Alzheimer's, Parkinson's, multiple sclerosis, and Lou Gehrig's disease Understanding risk factors and individually tailoring a diet and supplementary program Features a "Life Style Audit," quizzes, a brain fitness program with the most effective ways to exercise your brain, and a nutritional program that details the best brain food and supplements.
Practical Multivariate Analysis
DOWNLOAD
Author : Abdelmonem Afifi
language : en
Publisher: CRC Press
Release Date : 2019-10-16
Practical Multivariate Analysis written by Abdelmonem Afifi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-16 with Mathematics categories.
This is the sixth edition of a popular textbook on multivariate analysis. Well-regarded for its practical and accessible approach, with excellent examples and good guidance on computing, the book is particularly popular for teaching outside statistics, i.e. in epidemiology, social science, business, etc. The sixth edition has been updated with a new chapter on data visualization, a distinction made between exploratory and confirmatory analyses and a new section on generalized estimating equations and many new updates throughout. This new edition will enable the book to continue as one of the leading textbooks in the area, particularly for non-statisticians. Key Features: Provides a comprehensive, practical and accessible introduction to multivariate analysis. Keeps mathematical details to a minimum, so particularly geared toward a non-statistical audience. Includes lots of detailed worked examples, guidance on computing, and exercises. Updated with a new chapter on data visualization.
Oxidative Stress And Vascular Disease
DOWNLOAD
Author : John F. Keaney Jr.
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Oxidative Stress And Vascular Disease written by John F. Keaney Jr. and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.