Vascular Aging Facts And Factors
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Vascular Aging Facts And Factors
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Author : Elisabet Vila
language : en
Publisher: Frontiers E-books
Release Date :
Vascular Aging Facts And Factors written by Elisabet Vila and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
The increasing mean age of the population in developed countries has turned out to be an economic and social problem. Cardiovascular disease has long been considered to be age related in terms of their onset and progression. As such, we can say that the increase in life expectancy goes in parallel with increased incidence of cardiovascular disease. With age, a number of changes occur in the vasculature altering the homeostasis of the irrigated organs promoting target organ damage. While different adaptive mechanisms to protect vessels against mild stress have been described, the aging process induces a progressive failure of protective mechanisms, leading to vascular changes and higher susceptibility to cardiovascular diseases. Indeed, vascular aging is exacerbated by coexisting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Compelling evidence indicates that diminished endothelial relaxation and increase, decrease, or no change in contractile responses to several agonists is associated with aging. There is an increase of vasoconstrictor factors expression and a decrease of vasodilators. Morphologic changes include lumen diameter enlargement, wall thickening and alterations of matrix substances as increased collagen or decreased elastin deposition, ultimately leading to greater arterial stiffening (reduced compliance). Importantly, arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Cellular and molecular mechanisms have also been documented. Senescence at the cellular level involves alterations in Ca2+ signaling and down regulation of anti-aging proteins. Both endothelial and smooth muscle cells change their number, morphology, function and their regenerative ability. Aging is also associated with a gradual loss of antioxidant defense mechanisms, a proinflammatory shift in the cytokine expression profile and a production of reactive oxygen species such as superoxide (O2-) that promotes the breakdown of nitric oxide. Nitric oxide and O2- interact to form peroxynitrite known to nitrosylate proteins affecting their physiological function. However, vascular wall proteins may also suffer from other potentially deleterious modifications as glycation (Maillard reaction) and glyco-oxidative reactions with increasing age, which could be linked to the age-associated changes in vascular function. Various strategies have shown benefit in preventing, delaying or attenuating vascular aging. For instance, a healthy lifestyle including low fat diet and/or exercise have a favorable effect. Nevertheless, it yet remains to be fully demonstrated whether vascular aging can be pharmacologically prevented. This Research Topic is intended to bring together research efforts to understand the causes and consequences of vascular aging and propose new therapeutic strategies for the management of vascular senescence.
Frailty And Cardiovascular Diseases
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Author : Nicola Veronese
language : en
Publisher: Springer Nature
Release Date : 2020-01-01
Frailty And Cardiovascular Diseases written by Nicola Veronese and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-01 with Medical categories.
This book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part of the volume is dedicated to the biological mechanisms of frailty and cardiovascular disease, trying to find those in common between these two conditions. Since this book is dedicated to both researchers and clinicians, we have proposed some chapters to the importance of comprehensive geriatric assessment in the evaluation and treatment of cardiovascular diseases and frailty. In this regard, the importance of geriatric evaluation in cardiac surgery for older people is well covered. Finally, the importance of cardiac rehabilitation and physical exercise is summarized, being, actually, the most important treatments for both frailty and cardiovascular disease. Written by many well-known and widely published experts in their respective fields, this book will appeal to a wide readership such as researchers in the field and clinicians, especially suited in geriatric medicine and cardiology who, every day, face frail older patients.
Neurological Rehabilitation
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Author : Darcy Ann Umphred, PT, PhD, FAPTA
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-08-14
Neurological Rehabilitation written by Darcy Ann Umphred, PT, PhD, FAPTA and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-14 with Medical categories.
Using a problem-solving approach based on clinical evidence, Neurological Rehabilitation, 6th Edition covers the therapeutic management of people with functional movement limitations and quality of life issues following a neurological event. It reviews basic theory and covers the latest screening and diagnostic tests, new treatments, and interventions commonly used in today's clinical practice. This edition includes the latest advances in neuroscience, adding new chapters on neuroimaging and clinical tools such as virtual reality, robotics, and gaming. Written by respected clinician and physical therapy expert Darcy Umphred, this classic neurology text provides problem-solving strategies that are key to individualized, effective care. UNIQUE! Emerging topics are covered in detail, including chapters such as Movement Development Across the Lifespan, Health and Wellness: The Beginning of the Paradigm, Documentation, and Cardiopulmonary Interactions. UNIQUE! A section on neurological problems accompanying specific system problems includes hot topics such as poor vision, pelvic floor dysfunction, and pain. A problem-solving approach helps you apply your knowledge to examinations, evaluations, prognoses, and intervention strategies. Evidence-based research sets up best practices, covering topics such as the theory of neurologic rehabilitation, screening and diagnostic tests, treatments and interventions, and the patient's psychosocial concerns Information. Case studies use real-world examples to promote problem-solving skills. Non-traditional approaches to neurological interventions in the Alternative and Complementary Therapies chapter include the movement approach, energy approach, and physical body system approaches therapies. Terminology adheres to the best practices of the APTA as well as other leading physical therapy organizations, following The Guide to Physical Therapy Practice, the Nagi model, and the ICF World Health Model of patient empowerment. Updated illustrations provide current visual references. NEW chapters on imaging and robotics have been added. Updated chapters incorporate the latest advances and the newest information in neuroscience and intervention strategies. Student resources on an Evolve companion website include references with links to MEDLINE and more.
Preventive Cardiology A Companion To Braunwald S Heart Disease E Book
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Author : Roger Blumenthal
language : en
Publisher: Elsevier Health Sciences
Release Date : 2011-02-28
Preventive Cardiology A Companion To Braunwald S Heart Disease E Book written by Roger Blumenthal and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-28 with Medical categories.
Endorsed by the American Society for Preventive Cardiology! Preventive Cardiology - a new Companion to Braunwald's Heart Disease - addresses the prevention and risk stratification of cardiovascular disease so that you can delay the onset of disease and moderate the effects and complications. Drs. Roger Blumenthal, JoAnne Foody, and Nathan Wong discuss the full range of relevant considerations, including the epidemiology of heart disease, risk assessment, risk factors, multiple risk factor-based prevention strategies, and developments in genetics and personalized medicine. - Recognize the factors for prevention and risk stratification around cardiovascular disease and effectively delay the onset of disease and moderate the effects and complications, even for individual who are genetically predisposed. - Effectively navigate full range of considerations in prevention from epidemiology of heart disease, biology of atherosclerosis and myocardial infraction, risk assessment—established risk factors and emerging risk factors, multiple risk factor-based prevention strategies, and future directions—through genetics, personalized medicine, and much more. - Tap into the expertise of prominent leaders in cardiovascular disease prevention with guidance from Drs. Roger Blumenthal—longtime director of the Framingham Heart Study—JoAnne Foody, and Nathan Wong. - Gain a deeper understanding of the pathogenesis of disease and the rationale for management through discussions of basic science. - Apply current clinical practice guidelines to ensure optimal outcomes in both primary and secondary prevention.
Inflammation Advancing Age And Nutrition
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Author : Irfan Rahman
language : en
Publisher: Academic Press
Release Date : 2013-09-03
Inflammation Advancing Age And Nutrition written by Irfan Rahman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-03 with Technology & Engineering categories.
The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field. - Includes models of aging, including worm, mouse and human - Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health - Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition - Includes suggested nutritional interventions
Textbook Of Arterial Stiffness And Pulsatile Hemodynamics In Health And Disease
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Author : Julio A. Chirinos
language : en
Publisher: Academic Press
Release Date : 2022-03-28
Textbook Of Arterial Stiffness And Pulsatile Hemodynamics In Health And Disease written by Julio A. Chirinos and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-28 with Science categories.
Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease, Two Volume Set covers the principles, physiology, biologic pathways, clinical implications and therapeutics surrounding arterial stiffness and pulsatile hemodynamics, along with a thorough overview of the field. The book presents complex engineering concepts in a way that those in science and medicine can more easily understand. It includes detailed illustrations. Additionally, it presents advanced bioengineering concepts in boxes for readers who wants more in-depth biophysical knowledge. This is a must-have reference for students, researchers and clinicians interested in learning more about this field. - Incorporates case studies and calculations/worked examples with mathematical principles explained in a conceptual manner without complicated formulas - Features chapter contributions from leading international researchers and clinicians - Covers principles, physiology, biologic pathways, clinical implications and therapeutics
A Guide To Women S Health
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Author : Tolu Oyelowo
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2017-04-20
A Guide To Women S Health written by Tolu Oyelowo and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-20 with Health & Fitness categories.
Preceded by Mosby's guide to women's health / Tolu Oyelowo. St. Louis, Mo.: Mosby Elsevier, c2007.
Early Vascular Aging Eva
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Author : Pedro Guimarães Cunha
language : en
Publisher: Elsevier
Release Date : 2024-02-29
Early Vascular Aging Eva written by Pedro Guimarães Cunha and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-29 with Medical categories.
Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA. - Contains all the relevant information available on the main paradigm shifts in vascular aging research, from different fields of knowledge (from basic biology to epidemiology) - Reviews the most prominent evidence produced on early vascular aging (EVA), highlighting recent research advances, clinical applications, and research opportunities - Formulates, in each chapter, a set of research questions that need to be addressed, challenging the vast research community to take on new directions and collaborations
Handbook Of Research On Diverse Applications Of Nanotechnology In Biomedicine Chemistry And Engineering
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Author : Soni, Shivani
language : en
Publisher: IGI Global
Release Date : 2014-08-31
Handbook Of Research On Diverse Applications Of Nanotechnology In Biomedicine Chemistry And Engineering written by Soni, Shivani and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-31 with Technology & Engineering categories.
As a paradigm for the future, micro-scale technology seeks to fuse revolutionary concepts in science and engineering and then translate it into reality. Nanotechnology is an interdisciplinary field that aims to connect what is seen with the naked eye and what is unseen on the molecular level. The Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering examines the strengths and future potential of micro-scale technologies in a variety of industries. Highlighting the benefits, shortcomings, and emerging perspectives in the application of nano-scale technologies, this book is a comprehensive reference source for synthetic chemists, engineers, graduate students, and researchers with an interest in the multidisciplinary applications, as well as the ongoing research in the field.
Arterial Aging And Age Associated Arterial Diseases
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Author : Mingyi Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-24
Arterial Aging And Age Associated Arterial Diseases written by Mingyi Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-24 with categories.
The underlying mechanisms behind aging has long been a great scientific mystery that the biomedical research community has long studied. In developed nations, as the population grows older, increases in life expectancy is increasingly limited by our relatively poor control of chronic aging-associated diseases such as arterial aging. Among age-related conditions that negatively influence longevity. Growing evidence demonstrates that arterial aging is fundamentally caused by a proinflammatory process that begins at birth and results in detrimental effects that affects every organ system. Vascular aging is the leading risk factor for quintessential cardiovascular diseases such as hypertension and atherosclerosis. With aging, vascular walls develop a pro-inflammatory and stressed microenvironment characterized by both an upregulation of pro-inflammatory chemokines and cytokines as well as a down-regulation anti-inflammatory counterparts. This chronic imbalance in inflammatory regulatory networks is the key driver of changes at the cellular and molecular level that result in hypertensive and atherosclerotic arterial. Thus, an intervention of proinflammation may be a viable therapeutic intervention to reduce morbidity and mortality from cardiovascular diseases. In this eBook, we aim to supply an updated overview of the physiological and biochemical mechanisms that affect inflammation and vascular aging. We believe that this eBook will contribute to the understanding of the pathogenesis of many chronic or age-related diseases, as well as to their treatment with both current and new therapeutic approaches.