Textbook Of Arterial Stiffness And Pulsatile Hemodynamics In Health And Disease
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Textbook Of Arterial Stiffness And Pulsatile Hemodynamics In Health And Disease
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Author : Julio A. Chirinos
language : en
Publisher: Academic Press
Release Date : 2022-03-28
Textbook Of Arterial Stiffness And Pulsatile Hemodynamics In Health And Disease written by Julio A. Chirinos and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-28 with Science categories.
Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease, Two Volume Set covers the principles, physiology, biologic pathways, clinical implications and therapeutics surrounding arterial stiffness and pulsatile hemodynamics, along with a thorough overview of the field. The book presents complex engineering concepts in a way that those in science and medicine can more easily understand. It includes detailed illustrations. Additionally, it presents advanced bioengineering concepts in boxes for readers who wants more in-depth biophysical knowledge. This is a must-have reference for students, researchers and clinicians interested in learning more about this field. - Incorporates case studies and calculations/worked examples with mathematical principles explained in a conceptual manner without complicated formulas - Features chapter contributions from leading international researchers and clinicians - Covers principles, physiology, biologic pathways, clinical implications and therapeutics
Textbook Of Arterial Stiffness And Pulsatile Hemodynamics In Health And Disease
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Author : Julio A. Chirinos
language : en
Publisher: Academic Press
Release Date : 2021-10-01
Textbook Of Arterial Stiffness And Pulsatile Hemodynamics In Health And Disease written by Julio A. Chirinos and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-01 with Science categories.
Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease cover the principles, physiology, biologic pathways, clinical implications and therapeutics surrounding the topic, providing a thorough overview of the field and presenting complex engineering concepts in a way that those in science and medicine can more easily understand. Additionally, advanced bioengineering concepts are presented in boxes for the reader who wants more in-depth biophysical knowledge. This is a must-have reference for students, researchers and clinicians interested in learning more about this field. It includes detailed illustrations, animations and slideshows to assist readers with learning objectives. Provides a comprehensive review of the clinical implications of arterial stiffness and pulsatile hemodynamics and its role in human disease Incorporates case studies and calculations/worked examples with mathematical principles explained in a conceptual manner without complicated formulas Features chapter contributions from leading international researchers and clinicians
Home Blood Pressure In Health And Disease
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Author : Peder af Geijerstam
language : en
Publisher: Linköping University Electronic Press
Release Date : 2024-07-08
Home Blood Pressure In Health And Disease written by Peder af Geijerstam and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-08 with categories.
Hypertension is the most common preventable cause of premature all-cause mortality, primarily from cardiovascular disease (CVD). Individuals with dysglycemia, including prediabetes and diabetes, are at increased risk. Licorice intake raises blood pressure (BP) through the effects of glycyrrhizic acid (GA), but the true limit of safe intake is uncertain. Home BP has several benefits over BP measured at a clinic, including a higher predictive value for CVD. By combining office and home BP, it is possible to diagnose masked hypertension (MH), in which home but not office BP is elevated, and white coat hypertension (WCH), in which office but not home BP is elevated. The aim of this thesis was to advance our knowledge on home BP in relation to dysglycemia, markers of CVD, and licorice intake. The first 3 papers used data from the Linköping cohort of the prospective Swedish CArdioPulmonary bioImage Study (SCAPIS). Study IV was a randomized controlled cross-over study. Data was obtained from questionnaires, blood samples and office and home BP measurements. In studies I-III, pulse wave velocity (PWV), coronary artery calcium score (CACS), and carotid artery plaques as markers of CVD were also included. In Study I, we examined 5025 men and women aged 50-64 years old for the relation between dysglycemia and home BP. Both the systolic office and home BP measurements were positively as-sociated with dysglycemia. Participants with dysglycemia vs normoglycemia more often had MH. The findings were in line with previous research and strengthened the association between dysglycemia and MH. In Study II, we examined the associations between MH and markers of CVD in 4122 individuals without BP-lowering treatment. Of participants, 4.2% had MH, and these were more often men and had higher BMI than those with normotension. Participants with MH also had higher odds for CACS ≥100, an as-sociation which has previously been suggested as a trend. In Study III, we examined the relation between soluble P-se-lectin (sP-selectin) as a measure of thrombotic activity, plasma high-sensitivity C-reactive protein (hsCRP) as a measure of inflammation, and home BP in 4548 participants. Both markers were higher in each hypertension phenotype compared with sustained normotension. The quartile of participants with the highest sP-se-lectin values had higher odds for CACS ≥100 and carotid artery plaques. The association between sP-selectin and sustained hyper-tension was novel and not affected by adjustments for hsCRP. In Study IV, 28 healthy participants aged 18-30 years old were evaluated for the effects of a daily intake of licorice containing 100 mg of GA compared with a control product for 2 weeks. During the licorice intake period, the systolic home BP increased with 3.1 mmHg, and the suppression of serum aldosterone and plasma renin levels indicated that this was due to the licorice intake. In conclusion, this thesis further strengthens the idea that both home and office BP measurements have values beyond that of the other, and that home BP may be most valuable in individuals with dysglycemia and obesity, and in men. Finally, licorice may be more potent than previously known, suggesting the need for increased awareness. Förhöjt blodtryck (hypertoni) är den huvudsakliga orsaken till förtida död, främst genom hjärtkärlsjukdom. Flera mekanismer och riskfaktorer som kan förklara hypertoni har identifierats. Individer med förhöjt blodsocker, inklusive diabetes och dess förstadier, lö-per ökad risk för hjärtkärlsjukdom, och förhöjt blodsocker samexisterar ofta med hypertoni. Lakritsintag höjer blodtrycket genom dess beståndsdel glycyrrhizinsyra (GA), och även om både Europeiska unionen och Världshälsoorganisationen har föreslagit att ett intag av upp till 100 mg per dag sannolikt är säkert att förtära för de flesta individer, är den gränsnivån osäker. Jämfört med blodtryck som mäts på mottagningen av medicinskt utbildad personal har hemblodtryck flera fördelar, inklusive starkare koppling till framtida hjärtkärlsjukdom. Genom att kombinera mottagnings- och hemblodtryck går det att diagnosticera maskerad hypertoni (MH), då hemblodtrycket är förhöjt trots normalt mottagningsblodtryck, och vitrockhypertoni (WCH), då mottagningsblodtrycket men inte hemblodtrycket är förhöjd. Syftet med denna avhandling var att vidare utforska hemblodtryck i relation till förhöjt blodsocker, markörer för hjärtkärlsjukdom, och lakritsintag. Avhandlingens fyra arbeten baseras på två studier. I de första tre arbetena analyserades data från Linköpings-kohorten i the Swedish CArdioPulmonary bioImage Study (SCAPIS), en prospektiv studie av män och kvinnor i åldrarna 50-64 år. I det sista arbetet analyserades data från en lottad överkorsningsstudie. Data i studierna bestod av enkätsvar, blodprover, samt mottagnings- och hemblodtrycksmätningar. I studie I-III ingick även pulsvågshastighet, kalkhalt i kranskärlen vid skiktröntgen (CACS) och plack-förekomst i halspulsådrorna vid ultraljudsundersökning som markörer på hjärtkärlsjukdom. I det första delarbetet undersökte vi data för 5025 individer avseende blodtryck och förhöjt blodsocker. Både mottagnings- och hemblodtryck var associerat med förhöjt blodsocker. Deltagare med förhöjt blodsocker hade oftare MH jämfört med de med normalt blodsocker, och skillnaden mellan mottagnings- och hemblodtrycket var omvänt associerat med långtidsblodsocker. Fynden var i linje med tidigare forskning, och stärkte kända kopplingar mellan MH och förhöjt blodsocker. Förklaringarna till detta samband är okända, men möjliga sådana inkluderar selektiva effekter av blodtryckssänkande läkemedel hos individer med förhöjt blodsocker, samsjukligheter såsom fetma, och aktivering av det sympatiska nervsystemet. I det andra delarbetet analyserade vi förekomst av och associationer för MH hos 4122 individer utan pågående blodtryckssänkande läkemedelsbehandling. Av dessa hade 4.2% MH, och dessa var oftare män och hade högre BMI än de med normalt blodtryck. Deltagare med MH hade också högre pulsvågshastighet och oftare förhöjt CACS. Associationen mellan MH och markörer för hjärt-kärlsjukdom var tidigare känd och styrktes av våra resultat. I det tredje delarbetet undersökte vi 4548 deltagare avseende två blodprovsmarkörer: en för blodplättsaktivitet, lösligt P-selektin i blodet, och en för inflammation, högkänsligt C-reaktivt protein (hsCRP). Både P-selektin och hsCRP var högre vid hypertoni, oavsett typ, jämfört med vid normalt blodtryck. Den kvartil av deltagarna som hade högst P-selektin hade oftare WCH och hypertoni både hemma och på mottagningen, jämfört med normalt blodtryck, och oftare förhöjt CACS och plack i halspulsådrorna. Associationen mellan P-selektin och högt blodtryck både hemma och på mottagningen var inte tidigare känd, och påverkades inte av justering för hsCRP, vilket antydde att den inte enbart förklarades av inflammation. I det fjärde och sista delarbetet inkluderas 28 friska individer i åldrarna 18 till 30 år. I en överkorsningsstudie bad vi deltagarna att dagligen under 2 veckor inta antingen lakrits med ett innehåll av 100 mg GA eller en kontrollprodukt utan lakrits. Deltagarna undersöktes med avseende på hemblodtryck, liksom hormonnivåer i blodet. Under lakrits- jämfört med kontrollperioden steg det systoliska hemblodtrycket med 3,1 mmHg, och hormonnivåerna påverkades på ett sätt som talade för att GA påverkade blodtrycket. Sammanfattningsvis stärker studiernas resultat kunskapen om att blodtrycksmätning både på mottagningen och i hemmet är värdefullt både var för sig och tillsammans, och att hemblodtryck är särskilt värdefullt hos individer med förhöjt blodsocker eller övervikt, samt hos män. Slutligen visade sig små mängder lakrits påverka kroppen mer än tidigare känt, och ökad medvetenhet och bättre etikettering av lakritsprodukter kan vara befogad.
Heart Failure With Preserved Ejection Fraction An Issue Of Cardiology Clinics E Book
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Author : Scott L. Hummel
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-10-13
Heart Failure With Preserved Ejection Fraction An Issue Of Cardiology Clinics E Book written by Scott L. Hummel and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-13 with Medical categories.
In this issue of Cardiology Clinics, guest editors Drs. Scott Hummel and Matthew Konerman bring their considerable expertise to the topic of Heart Failure with Preserved Ejection Fraction. Top experts in the field cover key topics such as risk factors for heart failure with preserved ejection fraction (HFpEF); cardiopulmonary stress testing in HFpEF; hemodynamic assessment in HFpEF; the role of multi-modality imaging in the evaluation of HFpEF; and more. - Contains 13 relevant, practice-oriented topics including pharmacologic, non-pharmacologic, and device therapy for HFpEF; geriatric domains in patients with HFpEF; pulmonary hypertension in HFpEF; infiltrative, genetic, and other non-standard causes of HFpEF; echocardiography in HFpEF; and more. - Provides in-depth clinical reviews on heart failure with preserved ejection fraction, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Early Vascular Aging Eva
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Author : Pedro Guimarães Cunha
language : en
Publisher: Elsevier
Release Date : 2024-02-29
Early Vascular Aging Eva written by Pedro Guimarães Cunha and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-29 with Medical categories.
Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA. - Contains all the relevant information available on the main paradigm shifts in vascular aging research, from different fields of knowledge (from basic biology to epidemiology) - Reviews the most prominent evidence produced on early vascular aging (EVA), highlighting recent research advances, clinical applications, and research opportunities - Formulates, in each chapter, a set of research questions that need to be addressed, challenging the vast research community to take on new directions and collaborations
Mcdonald S Blood Flow In Arteries
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Author : Wilmer W. Nichols
language : en
Publisher: CRC Press
Release Date : 2022-09-16
Mcdonald S Blood Flow In Arteries written by Wilmer W. Nichols and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-16 with Medical categories.
For over sixty years, McDonald's Blood Flow in Arteries has remained the definitive reference work in the field of arterial hemodynamics, including arterial structure and function with special emphasis on pulsatile flow and pressure. Prestigious, authoritative and comprehensive, this seventh edition has been totally updated and revised with many new chapters. This edition continues to provide the theoretical basis required for a thorough understanding of arterial blood flow in both normal and pathological conditions, while keeping clinical considerations and readability paramount throughout. Key Features The definitive reference work on arterial hemodynamics Fully updated and revised to cover all recent advancements in the field
Integrative Approaches For Health
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Author : Bhushan Patwardhan
language : en
Publisher: Academic Press
Release Date : 2015-03-31
Integrative Approaches For Health written by Bhushan Patwardhan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-31 with Technology & Engineering categories.
Despite spectacular advances, modern medicine faces formidable global challenges in several key areas—notably the persistence of major killer diseases such as malaria, tuberculosis, leprosy, and newer threats including HIV/AIDS, resistant infections, and Ebola. As such, modern medicine has not led to a significant decrease in chronic diseases like diabetes, obesity, and other degenerative and autoimmune diseases. The authors believe that modern medicine needs to experience a paradigm shift, an integration of traditions—in particular from the ancient systems like Ayurveda and Yoga. Integrative Approaches for Health: Biomedical Research, Ayurveda and Yoga brings together the basic principles of interdisciplinary systems approach for an evolving construct of future medicine. Such an approach is already emerging at the cutting edge of current research in omics, bioinformatics, computational and systems biology. Several leading institutions of medicine have adopted Yoga and complementary medicine to widen their reach, and deepen effectiveness in therapeutic practices. The amalgam of modern medicine, with its strengths in scientific rigor, blended with the basic principles of life drawn from Ayurveda and Yoga might evolve into a medicine of tomorrow. Integrative approaches are no longer alternative, perhaps taking these approaches is the only possible way to heal our sick planet. This book introduces important trends and tools for biomedical researchers and physicians alike, to innovate the practice of medicine for the better. - Contains a harmonious confluence of ancient and modern concepts, historical perspectives, philosophical underpinnings, and a relevant review of literature supported by worldwide case studies. - Provides a critical analysis of ancient wisdom, pointing to potential areas for future research, which provide food for thought for public debate on integrative health care for the twenty-first century. - Explains Ayurveda knowledge, and its relevance to drug discovery, nutrition, genomics, epigenetics, regenerative biology, longevity and personalized medicine. - Shares Yoga knowledge insights, and explains its relevance to body–mind complex relationships, psychology, neurobiology, immunoendocrinology, bioenergetics, consciousness, and cognitive sciences. - Offers illustrations and logic diagrams for enhanced understanding of the concepts presented.
In Situ Molecular Pathology And Co Expression Analyses
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Author : Gerard J. Nuovo
language : en
Publisher: Academic Press
Release Date : 2013-02-07
In Situ Molecular Pathology And Co Expression Analyses written by Gerard J. Nuovo and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-07 with Science categories.
In Situ Molecular Pathology and Co-Expression Analyses explains, in easy-to-understand language, simplified ways of understanding and performing in situ hybridization and immunohistochemistry tests. The book also focuses on straightforward protocols used to simultaneously detect two or more proteins/nucleic acids within intact tissue by doing co-expression analyses. The fields of in situ hybridization and immunohistochemistry have expanded rapidly due to the use of computer-based analysis. To get the most out of these automated platforms, researchers and diagnostic biomedical investigators must have a solid understanding of the basics of in situ-based tests, protocols, and regimens for troubleshooting. Practicing molecular pathologists, clinical chemists, and toxicologists, as well as clinicians and researchers in training, will benefit from this book's clear presentation of protocols and theoretical framework. - Includes over 200 easy-to-follow experimental protocols - Features chapter-ending summaries of "Key Points to Remember" to bring beginners up to speed with any seasoned veteran in the field - Offers two chapters written by industry leaders in the fields of in situ hybridization, immunohistochemistry, and computer software for co-expression analyses
Maternal Hemodynamics
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Author : Christoph Lees
language : en
Publisher: Cambridge University Press
Release Date : 2018-05-03
Maternal Hemodynamics written by Christoph Lees and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-03 with Medical categories.
Discover new concepts in cardiovascular and hemodynamic functionality in feto-maternal medicine, from leading experts in the field.
Braunwald S Heart Disease E Book
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Author : Douglas P. Zipes
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-01-09
Braunwald S Heart Disease E Book written by Douglas P. Zipes and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-09 with Medical categories.
Trusted by generations of cardiologists for the latest, most reliable guidance in the field, Braunwald’s Heart Disease, 11th Edition, remains your #1 source of information on rapidly changing clinical science, clinical and translational research, and evidence-based medicine. This award-winning text has been completely updated, providing a superior multimedia reference for every aspect of this fast-changing field, including new material about almost every topic in cardiology. A unique update program by Dr. Braunwald creates a "living textbook" by featuring weekly Hot off the Press and periodic Late-Breaking Clinical Trials (including links to authors’ presentation slides). More than a dozen new chapters cover Chronic Lung Disorders and Cardiovascular Disease; Transcatheter Treatment of Congenital Heart Disease; Approach to the Patient with Valvular Heart Disease; Obesity and Cardiometabolic Disease; Environmental Exposures and CVD; Approach to the Patient with Cardiac Arrhythmias; Cardio-oncology, Precision Medicine, and more. New information on clinical cardiovascular genetics; MR PET; MR device compatibility; fibrosis; fusion imaging; OCT; IVUS; left atrial appendage exclusion approaches and other topics. Many new videos that elucidate coronary, peripheral, valvular, congenital heart diseases and other cardiovascular diseases. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.