Endothelin Receptors
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Endothelin Receptors
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Author : Robert R. Ruffolo, Jr.
language : en
Publisher: CRC Press
Release Date : 1995-05-19
Endothelin Receptors written by Robert R. Ruffolo, Jr. and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-05-19 with Science categories.
Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans. This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.
Endothelin Receptors And Signaling Mechanisms
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Author : David M. Pollock
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Endothelin Receptors And Signaling Mechanisms written by David M. Pollock and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
This book focuses on the wide variety of intracellular events that occur as a result of endothelin receptor activation. This includes a discussion of the various pathways by which endothelin activates Ca2+ signals from several intra- and extracellular sources and the effects of endothelin on ion channels and membrane function. In addition, the mechanisms by which endothelin influences the ion transport within the renal epithelium are covered, as well as the signal transduction pathways activated by endothelin in both cardiac tissue and vascular smooth muscle.
Endothelin And Its Inhibitors
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Author : Timothy D. Warner
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Endothelin And Its Inhibitors written by Timothy D. Warner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Recent publications have addressed specific aspects of the endothelins, such as their roles in disease or the importance of endothelin receptors. However, in this book the entire field of endothelins is covered. This includes the pathways of endothelin production and their regulation, the local and systemic actions of endothelins, receptors for the endothelins and the signalling pathways employed, and the involvement of endothelins in a range of diseases. Attention is also paid to the development through chemistry, pharmacology and toxicology of endothelin antagonists and endothelin-converting enzyme inhibitors, with mention of all the important members of these drug classes. This leads to well-rounded discussions of the potential therapeutic benefit of endothelin inhibitors.
Endothelin Receptors And Signaling Mechanisms
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Author : David M. Pollock
language : en
Publisher:
Release Date : 1998
Endothelin Receptors And Signaling Mechanisms written by David M. Pollock and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Cellular signal transduction categories.
This book focuses on the wide variety of intracellular events that occur as a result of endothelin receptor activation. This includes a discussion of the various pathways by which endothelin activates Ca[superscript 2+] signals from several intra- and extracellular sources and the effects of endothelin on ion channels and membrane function. In addition, the mechanisms by which endothelin influences the ion transport within the renal epithelium are covered as well as the signal transduction pathways activated by endothelin in both cardiac tissue and vascular smooth muscle.
Endothelins In Biology And Medicine
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Author : John P. Huggins
language : en
Publisher: CRC Press
Release Date : 1996-12-23
Endothelins In Biology And Medicine written by John P. Huggins and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-12-23 with Medical categories.
Endothelin-1 (ET-1), a peptide discovered in 1988, is one of the most potent contractors of vascular smooth muscle. Since their discovery, ETs have generated enormous interest in the scientific and pharmaceutical communities, prompting extensive research. This book addresses the latest findings regarding ETs-how they function, their effects, and characteristics. Divided into five sections, the book covers: endothelin receptors, endothelin synthesis and degradation, endothelin pathophysiology, ligand structure and activity relationships, and clinical studies. Pharmacologists, toxicologists, and pharmaceutical researchers will all benefit from this thorough review of current findings and future directions in ET research.
Altered Expression Of Contractile Endothelin Receptors In The Vascular Bed
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Author : Mikael Adner
language : en
Publisher:
Release Date : 1998
Altered Expression Of Contractile Endothelin Receptors In The Vascular Bed written by Mikael Adner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Endothelins categories.
Endothelin In Renal Physiology And Disease
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Author : M. Barton
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2011-09-01
Endothelin In Renal Physiology And Disease written by M. Barton and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-01 with Medical categories.
Endothelin is a 21-amino acid peptide that exerts uniquely potent and long-lasting effects on the kidney, including regulation of water and electrolyte excretion, blood pressure, cell growth, inflammation and fibrosis. During the past 10 years, the field has evolved rapidly; we are now uncovering the potential importance of endothelin receptor antagonists (ERAs) in the treatment of kidney disease.This book reviews experimental concepts, preclinical studies and clinical data which form the basis of our current understanding of the association between endothelin and kidney disease. Acclaimed experts in pharmacology, molecular biology, physiology, cardiovascular medicine, and nephrology have contributed timely reviews dealing with renal pharmacology and physiology of endothelin, the role of endothelin in renal disease development and ERAs in preclinical studies, and the current state of clinical development of ERA therapy in renal medicine.The publication at hand will be a valuable reference source for nephrologists, internists and other healthcare professionals, renal physiologists and molecular biologists, post-doctoral researchers and students in the life sciences, as well as for scientists and decision makers in drug research and development.
Peptide Research Protocols
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Author : Janet J. Maguire
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Peptide Research Protocols written by Janet J. Maguire and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Medical categories.
A panel of multidisciplinary experts describes in detail readily reproducible methods to investigate all aspects of the endothelin system from its synthesis and metabolism, to its function in health and disease. Theses methods use state-of-the-art molecular techniques to quantify the expression of mRNA for both endothelin receptors and the endothelin converting enzymes. They show how peptides, precursors, receptors, and synthetic enzymes can be localized and quantified in plasma, culture supernatants, tissue homogenate, and tissue sections using antibodies. Several in vivo protocols illustrate the role of the endothelin peptides in healthy human individuals and describe animal models that can be used to predict the therapeutic potential of cardiovascular drugs that manipulate endothelin synthesis or function.
Endothelin
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Author : Robert F. Highsmith
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Endothelin written by Robert F. Highsmith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinical, and industrial researchers summarize the dramatic recent progress in endothelin research and indicate the optimal direction of future studies. The contributors produce a critical evaluation of endothelin chemistry and pharmacology, its mechanism of action, and its physiological functions. The book is certain to become the new standard reference source for both basic scientists and informed clinicians who want a clear idea of the roles endothelin may play in cardiovascular physiology and pathology.
The Endothelins
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Author : Winifred G. Nayler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Endothelins written by Winifred G. Nayler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
"What we call the beginning is often the end, and to make an end is to make a beginning. The end is where we start from." T. S. ELIOT, "Geroniton" The discovery of endothelin-l was both an end and a beginning. It is an end because this discovery has started a plethora of investigations as to endothe1in's sites of production, mode of action, it's normal and abnormal physiological role and its involvement in a variety of pathological conditions ranging from renal failure to myocardial infarction, cardiac hypertrophy, hyperten sion, cyclosporine induced toxicity, mental depression, renal failure, stress related illness, and even stroke and sudden death. It is a beginning because no one can foresee where the investigations will ultimately lead, or how they will end. The discovery of the endothelins was a very recent event and soon specialist books will start to appear dealing in detail with different aspects of their chemistry, physiological role and pathological importance. The present book is intended to act as a guide and primer for those who are becoming intrigued by the many endothelin related articles which are now appearing in the journals but who as yet have not had the time or opportunity to be caught up in the web of enthusiasm and excitement which is motivating those more directly involved in the field of research.