Engineering New Self Assembling Biomaterials Based On Beta Sheet Forming Peptides
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Engineering New Self Assembling Biomaterials Based On Beta Sheet Forming Peptides
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Author : Joel Henderson Collier
language : en
Publisher:
Release Date : 2003
Engineering New Self Assembling Biomaterials Based On Beta Sheet Forming Peptides written by Joel Henderson Collier and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
This thesis deals with the development of novel strategies for self-assembling biomaterials based on short beta-sheet fibril-forming peptides. These materials are potentially useful for a variety of biomedical applications, including tissue engineering and controlled drug release, and several aspects of these materials have been explored in this thesis in an effort to improve their clinical utility. First, a strategy for rapidly and uniformly triggering peptide self-assembly was developed. Stimulus-sensitive liposomes were utilized to sequester salts and release them in response to stimuli such as warming to body temperature or exposure to near infra-red light. Triggered salt release in turn initiated rapid self-assembly of extravesicular peptide and the transformation of the peptide/liposome suspension from a solution to a hydrogel. We show that peptide self-assembly can be rapidly, uniformly, and specifically triggered, with the storage modulus increasing three orders of magnitude upon triggering. This rapid triggering strategy is potentially useful for injectable biomaterial applications. In the second research thrust, a self-assembling peptide was developed that also possessed enzymatic activity for the cross-linking enzyme tissue transglutaminase. We then utilized tissue transglutaminase to conjugate cell-interactive peptides to the self-assembled structure and investigated cell attachment to these functionalized scaffolds. Such a strategy is potentially useful for designing biospecific self-assembling scaffolds for tissue engineering or wound healing. In the final research focus, to modulate the nanostructure of the self-assembled fibrillar structures, we developed a series of self-assembling polyethylene glycol-conjugated peptides. We found that polyethylene glycol conjugation significantly altered fibril morphology, including width, length, and degree of lateral aggregation. As previous beta-sheet fibrillar self-assembled materials have shown particular intransigence to such modification of the fibrillar structure, this strategy may be a useful route for tailoring the physical properties of these materials. As a whole, the strategies developed in this thesis address previous shortcomings of beta-sheet peptide-based self-assembling materials in an effort to bring them closer to clinical application.
Peptide Based Biomaterials
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Author : Mustafa O. Guler
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-11-18
Peptide Based Biomaterials written by Mustafa O. Guler and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-18 with Science categories.
Research and new tools in biomaterials development by using peptides are currently growing, as more functional and versatile building blocks are used to design a host of functional biomaterials via chemical modifications for health care applications. It is a field that is attracting researchers from across soft matter science, molecular engineering and biomaterials science. Covering the fundamental concepts of self-assembly, design and synthesis of peptides, this book will provide a solid introduction to the field for those interested in developing functional biomaterials by using peptide derivatives. The bioactive nature of the peptides and their physical properties are discussed in various applications in biomedicine. This book will help researchers and students working in biomaterials and biomedicine fields and help their understanding of modulating biological processes for disease diagnosis and treatments.
Self Assembled Peptide Nanostructures
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Author : Jaime Castillo
language : en
Publisher: CRC Press
Release Date : 2012-11-21
Self Assembled Peptide Nanostructures written by Jaime Castillo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-21 with Medical categories.
The self-organization of bionanostructures into well-defined functional machineries found in nature has been a priceless source of ideas for researchers. The molecules of life, proteins, DNA, RNA, etc., as well as the structures and forms that these molecules assume serve as rich sources of ideas for scientists or engineers who are interested in developing bio-inspired materials for innovations in biomedical fields. In nature, molecular self-assembly is a process by which complex three-dimensional structures with well-defined functions are constructed, starting from simple building blocks such as proteins and peptides. This book introduces readers to the theory and mechanisms of peptide self-assembly processes. The authors present the more common peptide self-assembled building blocks and discuss how researchers from different fields can apply self-assembling principles to bionanotechnology applications. The advantages and challenges are mentioned together with examples that reflect the state of the art of the use of self-assembled peptide building blocks in nanotechnology.
Dissertation Abstracts International
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Author :
language : en
Publisher:
Release Date : 2008
Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Dissertations, Academic categories.
Design Principle And Application Of Self Assembled Nanobiomaterials In Biology And Medicine
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Author : Alok Pandya
language : en
Publisher: Academic Press
Release Date : 2022-08-04
Design Principle And Application Of Self Assembled Nanobiomaterials In Biology And Medicine written by Alok Pandya and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-04 with Medical categories.
Design, Principle and Application of Self-Assembled Nanobiomaterials in Biology and Medicine discusses recent advances in science and technology using nanoscale units that show the novel concept of combining nanotechnology with various research disciplines within both the biomedical and medicine fields. Self-assembly of molecules, macromolecules, and polymers is a fascinating strategy for the construction of various desired nanofabrication in chemistry, biology, and medicine for advanced applications. It has a number of advantages: (1) It is involving atomic-level modification of molecular structure using bond formation advanced techniques of synthetic chemistry. (2) It draws from the enormous wealth of examples in biology for the development of complex, functional structures. (3) It can incorporate biological structures directly as components in the final systems. (4) It requires that the target self-assembled structures be thermodynamically most stable with relatively defect-free and self-healing. In this book, we cover the various emerging self-assembled nanostructured objects including molecular machines, nano-cars molecular rotors, nanoparticles, nanosheets, nanotubes, nanowires, nano-flakes, nano-cubes, nano-disks, nanorings, DNA origami, transmembrane channels, and vesicles. These self-assembled materials are used for sensing, drug delivery, molecular recognition, tissue engineering energy generation, and molecular tuning. - Provides a basic understanding of how to design, and implement various self-assembled nanobiomaterials - Covers principles implemented in the constructions of novel nanostructured materials - Offers many applications of self-assemblies in fluorescent biological labels, drug and gene delivery, bio-detection of pathogens, detection of proteins, probing of DNA structure, tissue engineering, and many more
Self Assembling Biomaterials
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Author : Helena S. Azevedo
language : en
Publisher: Woodhead Publishing
Release Date : 2018-04-17
Self Assembling Biomaterials written by Helena S. Azevedo and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-17 with Technology & Engineering categories.
Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. - Explores both theoretical and practical aspects of self-assembly in biomaterials - Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials - Examines the use of dynamic self-assembling biomaterials
Smart Materials For Tissue Engineering
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Author : Qun Wang
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-05-03
Smart Materials For Tissue Engineering written by Qun Wang and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-03 with Science categories.
In the last couple of decades, research in the area of tissue engineering has witnessed tremendous progress. The focus has been on replacing or facilitating the regeneration of damaged or diseased cell, tissue or organs by applying a biomaterial support system, and a combination of cells and bioactive molecules. In addition new smart materials have been developed which provide opportunities to fabricate, characterize and utilize materials systematically to control cell behaviours and tissue formation by biomimetic topography that closely replicate the natural extracellular matrix. Following on from Smart Materials for Tissue Engineering: Fundamental Principles, this book comprehensively covers the different uses of smart materials in tissues engineering, providing a valuable resource for biochemists, materials scientists and biomedical engineers working in industry and academia.
Bio Instructive Scaffolds For Musculoskeletal Tissue Engineering And Regenerative Medicine
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Author : Justin Brown
language : en
Publisher: Academic Press
Release Date : 2016-11-03
Bio Instructive Scaffolds For Musculoskeletal Tissue Engineering And Regenerative Medicine written by Justin Brown and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-03 with Technology & Engineering categories.
Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations. The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications. In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics. - Presents a self-contained work for the field of musculoskeletal tissue engineering and regenerative medicine - Focuses on how materials of structures can be designed to be resistant while promoting viable grafts - Contains major tissue types that are covered with a strategy for each material and structure
Nanotechnology For Biology And Medicine
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Author : Gabriel A. Silva
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-10-22
Nanotechnology For Biology And Medicine written by Gabriel A. Silva and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-22 with Medical categories.
This text book will bring together a mix of both internationally known and established senior scientists along side up and coming (but already accomplished) junior scientists that have varying expertise in fundamental and applied nanotechnology to biology and medicine.
Handbook Of The Extracellular Matrix
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Author : F. Raquel Maia
language : en
Publisher: Springer Nature
Release Date : 2024-07-16
Handbook Of The Extracellular Matrix written by F. Raquel Maia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-16 with Technology & Engineering categories.
This book comprises 6 sections covering the fundamentals of the extracellular matrix, as well as the development and challenges of using biologically-derived materials, and its advanced biomedical applications. The first section is dedicated to the extracellular matrix, while the other 5 sections are each dedicated to a particular type of material. This book reports the fundamentals of the extracellular matrix and its impact on the development of innovative materials; provides an overview of the advanced methodologies used to develop biologically-derived materials; and describes the challenges of the synthesis and processing of the different materials. Furthermore, it presents the biological activities, structural and physicochemical properties of such materials, and the modification methods pursued to improve their inherent properties. The wide range of advanced applications are covered as well, including the combination with emerging technologies, underlying tissue-engineered scaffolding, drug delivery systems, 3D in vitro tissue and cancer models, 3D bioprinted models, bioinks, and more. This reference work serves as a core reference for multidisciplinary students (undergraduates and Ph.D. students) and a wide range of established researchers and professionals working in the medical field, e.g., orthopaedics, radiology, dentistry, and cancer.