Engineering Tuneable Gene Circuits In Yeast

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Engineering Tuneable Gene Circuits In Yeast
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Author : Stephen Checkley
language : en
Publisher: GRIN Verlag
Release Date : 2015-09-14
Engineering Tuneable Gene Circuits In Yeast written by Stephen Checkley and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-14 with Science categories.
Doctoral Thesis / Dissertation from the year 2011 in the subject Chemistry - Bio-chemistry, grade: pass, University of Manchester (Manchester Institute of Biotechnology), course: Systems biology doctoral training program -synthetic biology, language: English, abstract: Synthetic biology is an emergent field incorporating aspects of computer science, molecular biology-based methodologies in a systems biology context, taking naturally occurring cellular systems, pathways, and molecules, and selectively engineering them for the generation of novel or beneficial synthetic behaviour. This study described the construction of a novel synthetic gene circuit with interchangeable gene expression components enabling the investigation of tuning circuits for optimal signal to noise ratio. The circuit utilises the inducible downstream transcriptional activation properties of the pheromone-response pathway in the budding yeast Saccharomyces cerevisiae as the basis for initiation.
Engineering Tuneable Gene Circuits In Yeast
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Author : Stephen Checkley
language : en
Publisher:
Release Date : 2015-10-23
Engineering Tuneable Gene Circuits In Yeast written by Stephen Checkley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-23 with categories.
Doctoral Thesis / Dissertation from the year 2011 in the subject Chemistry - Bio-chemistry, grade: pass, University of Manchester (Manchester Institute of Biotechnology), course: Systems biology doctoral training program -synthetic biology, language: English, abstract: Synthetic biology is an emergent field incorporating aspects of computer science, molecular biology-based methodologies in a systems biology context, taking naturally occurring cellular systems, pathways, and molecules, and selectively engineering them for the generation of novel or beneficial synthetic behaviour. This study described the construction of a novel synthetic gene circuit with interchangeable gene expression components enabling the investigation of tuning circuits for optimal signal to noise ratio. The circuit utilises the inducible downstream transcriptional activation properties of the pheromone-response pathway in the budding yeast Saccharomyces cerevisiae as the basis for initiation.
Engineering Tuneable Gene Circuits In Yeast
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Author : Stephen Checkley
language : en
Publisher:
Release Date : 2011
Engineering Tuneable Gene Circuits In Yeast written by Stephen Checkley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
The Science And Applications Of Synthetic And Systems Biology
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-12-30
The Science And Applications Of Synthetic And Systems Biology written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-30 with Science categories.
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Engineering Yeast To Produce Plant Natural Products
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Author : Yongjun Wei
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-20
Engineering Yeast To Produce Plant Natural Products written by Yongjun Wei and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-20 with Science categories.
Genetic And Genome Wide Microbial Insights Bioenergy
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Author : Javid Ahmad Parray
language : en
Publisher: Academic Press
Release Date : 2025-02-24
Genetic And Genome Wide Microbial Insights Bioenergy written by Javid Ahmad Parray and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-24 with Science categories.
Genetic and Genome-Wide Microbial Insights: Bioenergy: Microbial Genomics (Volume 3) delves into the cutting-edge developments in the field of metagenomics, encompassing both metatranscriptomics and metaproteomics. This comprehensive resource highlights the significant potential of metagenomics in screening previously uncultivated microbial species. It underscores the pivotal role of these advanced genomic techniques in accessing elusive microorganisms, thereby revolutionizing the production of biofuels. This book emphasizes the practicality of these methods, aiming to make biofuel production more economically feasible and efficient. "Genetic and Genome-Wide Microbial Insights: Bioenergy" offers both a foundational overview and the most recent advancements in microbial genomics, computational genomics, and enzyme engineering. It details the process of upscaling and bio-prospecting microbial strains, specifically tailored for biofuel production, providing a comprehensive guide that bridges basic concepts with cutting-edge research. This book covers a range of topics, including advanced microbial fuel production techniques, Sustainable bioenergy (genomics and biofuel development) and microbial engineering. The comprehensive chapters in this book will appeal to readers from diverse backgrounds in biology, life sciences, agriculture, environmental engineering, genome engineering, and even medicine. - Explores the integration of metagenomics and enzyme engineering in the upscaling of biofuel production - Presents recent 'omics' applications and delves into the biological mechanisms that drive microbial biofuel production - Traces the journey from metagenomics to byproducts, focusing on the bio-prospecting of microbial strains
Synthetic Biology
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Author : Christina Smolke
language : en
Publisher: John Wiley & Sons
Release Date : 2018-06-05
Synthetic Biology written by Christina Smolke and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-05 with Science categories.
A review of the interdisciplinary field of synthetic biology, from genome design to spatial engineering. Written by an international panel of experts, Synthetic Biology draws from various areas of research in biology and engineering and explores the current applications to provide an authoritative overview of this burgeoning field. The text reviews the synthesis of DNA and genome engineering and offers a discussion of the parts and devices that control protein expression and activity. The authors include information on the devices that support spatial engineering, RNA switches and explore the early applications of synthetic biology in protein synthesis, generation of pathway libraries, and immunotherapy. Filled with the most recent research, compelling discussions, and unique perspectives, Synthetic Biology offers an important resource for understanding how this new branch of science can improve on applications for industry or biological research.
Metabolic Engineering For Bioprocess Commercialization
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Author : Stephen Van Dien
language : en
Publisher: Springer
Release Date : 2016-07-16
Metabolic Engineering For Bioprocess Commercialization written by Stephen Van Dien and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-16 with Science categories.
This volume reviews the current metabolic engineering tools and technologies from a practical point of view, and guides researchers as they overcome challenges at various stages of organism and bioprocess development. Microbes have been engineered to produce a variety of industrial products such as fuels, basic chemicals, fine chemicals, nutritional supplements, and pharmaceutical intermediates, and new tools such as gene synthesis, advanced cloning techniques, ‘omics’ analysis, and mathematical modeling have greatly accelerated the pace of innovation in the field. Written by leading experts in the field from both academia and industry, key topics include synthetic biology, pathway engineering, metabolic flux manipulation, adaptive evolution, and fermentation process scale-up. It is suitable for non-specialists, and is a valuable resource for anyone embarking on the exciting path to harnessing the metabolic potential of microorganisms.
Synthetic Biology
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Author : Robert A. Meyers
language : en
Publisher: John Wiley & Sons
Release Date : 2015-05-18
Synthetic Biology written by Robert A. Meyers and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-18 with Science categories.
These two volumes contain a selection of updated articles from the acclaimed Meyers Encyclopedia of Molecular Cell Biology and Molecular Medicine, the most authoritative resource in cell and molecular biology, combined with new articles by "founding fathers" in the field. The work is divided into six sections: + Biological Basis + Modeling + Modular Parts and Circuits + Synthetic Genomes + Diseases and Therapeutics + Chemicals Production. Ideally suited as advanced reading for students and postdocs, and with all current research trends covered by an impressive number of leading figures in the field, this is the first choice reference for research institutions.
Microbial Cell Factories Engineering For Production Of Biomolecules
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Author : Vijai Singh
language : en
Publisher: Academic Press
Release Date : 2021-02-13
Microbial Cell Factories Engineering For Production Of Biomolecules written by Vijai Singh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-13 with Science categories.
Microbial Cell Factories Engineering for Production of Biomolecules presents a compilation of chapters written by eminent scientists worldwide. Sections cover major tools and technologies for DNA synthesis, design of biosynthetic pathways, synthetic biology tools, biosensors, cell-free systems, computer-aided design, OMICS tools, CRISPR/Cas systems, and many more. Although it is not easy to find relevant information collated in a single volume, the book covers the production of a wide range of biomolecules from several MCFs, including Escherichia coli, Bacillus subtilis, Pseudomonas putida, Streptomyces, Corynebacterium, Cyanobacteria, Saccharomyces cerevisiae, Pichia pastoris and Yarrowia lipolytica, and algae, among many others. This will be an excellent platform from which scientific knowledge can grow and widen in MCF engineering research for the production of biomolecules. Needless to say, the book is a valuable source of information not only for researchers designing cell factories, but also for students, metabolic engineers, synthetic biologists, genome engineers, industrialists, stakeholders and policymakers interested in harnessing the potential of MCFs in several fields. - Offers basic understanding and a clear picture of various MCFs - Explains several tools and technologies, including DNA synthesis, synthetic biology tools, genome editing, biosensors, computer-aided design, and OMICS tools, among others - Harnesses the potential of engineered MCFs to produce a wide range of biomolecules for industrial, therapeutic, pharmaceutical, nutraceutical and biotechnological applications - Highlights the advances, challenges, and future opportunities in designing MCFs