Epigenetics Nuclear Organization Gene Function
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Epigenetics Nuclear Organization Gene Function
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Author : John C. Lucchesi
language : en
Publisher: Oxford University Press
Release Date : 2018-12-19
Epigenetics Nuclear Organization Gene Function written by John C. Lucchesi and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-19 with Science categories.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
Epigenetics Nuclear Organization And Gene Function
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Author : John C. Lucchesi
language : en
Publisher:
Release Date : 2019
Epigenetics Nuclear Organization And Gene Function written by John C. Lucchesi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Epigenetics categories.
This title provides a framework to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. It also highlights the role of the three-dimensional organization of the genetic material itself and its distribution in a functionally compartmentalized nucleus.
Cytogenetics
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Author : Marcelo L. Larramendy
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-07-14
Cytogenetics written by Marcelo L. Larramendy and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-14 with Medical categories.
This edited book, Cytogenetics - Classical and Molecular Strategies for Analysing Heredity Material, presents recent advances in the field of cytogenetics, paying special attention to methodological achievements developed worldwide that have driven the field forward. The contributors clearly discuss several concepts and approaches useful for understanding chromosomal structure and function at its various levels, highlighting chromosomes as visible carriers of heredity material.
Epigenetic Mechanisms Of Gene Regulation
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Author : Vincenzo E. A. Russo
language : en
Publisher:
Release Date : 1996
Epigenetic Mechanisms Of Gene Regulation written by Vincenzo E. A. Russo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.
Nuclear Organization And Function
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Author : Terri Grodzicker
language : en
Publisher:
Release Date : 2011
Nuclear Organization And Function written by Terri Grodzicker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Cell nuclei categories.
This volume is based on presentations by the world-renowned investigators who gathered at the 75th annual Cold Spring Harbor Symposium on Quantitative Biology to discuss the organization and function of the cell nucleus. It reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes. The topics examined include nuclear domains, chromatin organization, transcription and RNA processing, DNA replication, nuclear reprogramming, and epigenetics. Cancer, premature aging syndromes, and other diseases that may be associated with altered nuclear organization are also covered.
Epigenetic Gene Expression And Regulation
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Author : Suming Huang
language : en
Publisher: Academic Press
Release Date : 2015-10-19
Epigenetic Gene Expression And Regulation written by Suming Huang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-19 with Science categories.
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. - Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies - Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring - Chapters are replete with clinical examples to empower the basic biology with translational significance - Offers more than 100 illustrations to distill key concepts and decipher complex science
Cultural Memory
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Author : Donald R. Wehrs
language : en
Publisher: Taylor & Francis
Release Date : 2022-11-29
Cultural Memory written by Donald R. Wehrs and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-29 with Psychology categories.
Bringing together neuroscientists, social scientists, and humanities scholars in cross-disciplinary exploration of the topic of cultural memory, this collection moves from seminal discussions of the latest findings in neuroscience to variegated, specific case studies of social practices and artistic expressions. This volume highlights what can be gained from drawing on broad interdisciplinary contexts in pursuing scholarly projects involving cultural memory and associated topics. The collection argues that contemporary evolutionary science, in conjunction with studies interconnecting cognition, affect, and emotion, as well as research on socially mediated memory, provides innovatively interdisciplinary contexts for viewing current work on how cultural and social environments influence gene expression and neural circuitry. Building on this foundation, Cultural Memory turns to the exploration of the psychological processes and social contexts through which cultural memory is shaped, circulated, revised, and contested. It investigates how various modes of cultural expression—architecture, cuisine, poetry, film, and fiction—reconfigure shared conceptualizing patterns and affectively mediated articulations of identity and value. Each chapter showcases research from a wide range of fields and presents diverse interdisciplinary contexts for future scholarship. As cultural memory is a subject that invites interdisciplinary perspectives and is relevant to studying cultures around the world, of every era, this collection addresses an international readership comprising scholars from the humanities, social sciences, and natural sciences, from advanced undergraduates to senior researchers.
Epigenetics
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Epigenetics written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting level at which genes can be regulated.
Epigenetic Regulation And Epigenomics
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Author : Robert A. Meyers
language : en
Publisher: John Wiley & Sons
Release Date : 2012-05-29
Epigenetic Regulation And Epigenomics written by Robert A. Meyers and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-29 with Science categories.
Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Epigenetics Development And Disease
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Author : Tapas Kumar Kundu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-13
Epigenetics Development And Disease written by Tapas Kumar Kundu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-13 with Medical categories.
Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.