Nuclear Organization And Function
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Nuclear Organization And Function
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Author : Terri Grodzicker
language : en
Publisher:
Release Date : 2011
Nuclear Organization And Function written by Terri Grodzicker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Cell nuclei categories.
The 75th Cold Spring Harbor Symposium volume reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes.
Nuclear Structure And Gene Expression
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Author : R. Curtis Bird
language : en
Publisher: Elsevier
Release Date : 1996-11-28
Nuclear Structure And Gene Expression written by R. Curtis Bird and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-11-28 with Science categories.
Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology. * Mechanisms of interaction between nuclear structure and genes * Gene expression regulation by elements of the nuclear matrix * How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology
Nuclear Matrix
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Author : Ronald Berezney
language : en
Publisher: Elsevier
Release Date : 1995
Nuclear Matrix written by Ronald Berezney and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
Research on the nuclear matrix has grown enormously since Bereney and Coffey first reported its isolation and initial characterization in 1974. Since then, more than 1000 papers have been published on the subject by numerous workers around the world. This is the first book devoted to reviewing the major developments in this growing field. Key Features * The chapters cover a variety of topics, including: * Isolation of the nuclear matrix * Nuclear structure morphology in situ * Structural domains of the nuclear matrix and its components * Biochemistry and molecular biology of the matrix proteins and associated DNA and RNA * Functional properties associated with the nuclear matrix * DNA replication * Transcription * RNA splicing * Transcription regulation * Intranuclear and nucleocytoplasmic transport and targeting * Cell cycle regulation
Genome Organization And Function In The Cell Nucleus
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Author : Karsten Rippe
language : en
Publisher: John Wiley & Sons
Release Date : 2012-01-09
Genome Organization And Function In The Cell Nucleus written by Karsten Rippe and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Science categories.
By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.
Epigenetics Nuclear Organization Gene Function
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Author : John C. Lucchesi
language : en
Publisher: Oxford University Press
Release Date : 2018-12-19
Epigenetics Nuclear Organization Gene Function written by John C. Lucchesi and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-19 with Science categories.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
The Cell Nucleus
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Author : Harris Busch
language : en
Publisher: Elsevier
Release Date : 2012-12-02
The Cell Nucleus written by Harris Busch and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
The Cell Nucleus, Volume I reports the basic concepts of cell nucleus, including nuclear structure, the interaction between the nucleus and cytoplasm, and the chromatin. This volume first describes the nucleus’ morphological structures and relates these structures to its functions. It then discusses nuclear organization in plant cells; morphology and biochemistry of the slime mold nucleus; and structure, function, and properties of nuclear envelope. In addition, it addresses the molecular movements between nucleus and cytoplasm against a concentration gradient, presents experiments with animal cell heterokaryons, and explains the genome in specialized cells. It also explores the organization of the chromatin fiber; the human chromosome structure before and after banding; and the ultrastructure and function of heterochromatin and euchromatin.
Nuclear Mechanics And Genome Regulation
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-10-12
Nuclear Mechanics And Genome Regulation written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-12 with Science categories.
In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. Both classic and state-of-the-art methods readily adaptable and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields
Nuclear Pore Complexes In Genome Organization Function And Maintenance
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Author : Maximiliano D’Angelo
language : en
Publisher: Springer
Release Date : 2018-02-02
Nuclear Pore Complexes In Genome Organization Function And Maintenance written by Maximiliano D’Angelo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-02 with Medical categories.
The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
The Nuclear Envelope
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Author : David Evans
language : en
Publisher: Taylor & Francis
Release Date : 2004-08-02
The Nuclear Envelope written by David Evans and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-02 with Science categories.
The Nuclear Envelope brings together the major current topics in nuclear envelope structure, transport, transcriptional regulation and cell signaling. The volume is divided into four sections: 1. Proteins of the nuclear envelope, including nuclear envelope proteomics, structure and function. 2. Nuclear pores and transport at the nuclear envelope, including pore complex structure, assembly and function and import and export pathways. 3. Nuclear envelope dynamics, including dynamics of lamina assembly and disassembly. 4. Nuclear signaling and transcription regulation, including signaling to the nucleus and spectrin repeat proteins and their implications or communication between the nucleus and cytoplasm.