Nuclear Organization And Function
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Nuclear Organization And Function
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Author : Terri Grodzicker
language : en
Publisher:
Release Date : 2011
Nuclear Organization And Function written by Terri Grodzicker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Cell nuclei categories.
This volume is based on presentations by the world-renowned investigators who gathered at the 75th annual Cold Spring Harbor Symposium on Quantitative Biology to discuss the organization and function of the cell nucleus. It reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes. The topics examined include nuclear domains, chromatin organization, transcription and RNA processing, DNA replication, nuclear reprogramming, and epigenetics. Cancer, premature aging syndromes, and other diseases that may be associated with altered nuclear organization are also covered.
Genome Organization And Function In The Cell Nucleus
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Author : Karsten Rippe
language : en
Publisher: John Wiley & Sons
Release Date : 2012-01-09
Genome Organization And Function In The Cell Nucleus written by Karsten Rippe and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Science categories.
By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.
Nuclear Structure And Function
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Author : Miguel Berrios
language : en
Publisher: Academic Press
Release Date : 1998
Nuclear Structure And Function written by Miguel Berrios and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
This volume is a comprehensive guide to the methodologies used in the study of structural domains of cell nuclei. The text covers chromatin, the karyoskeleton, the soluble domain, and the nucleolus. It details methods that are used to isolate components from these domains and techniques used to assemble and disassemble nuclear elements. There is also coverage of three-dimensional mapping and localization of nuclear processes. Key Features * Provides a practical laboratory guide for studying cell nuclei * Includes comprehensive and easy-to-follow protocols
Epigenetics Nuclear Organization Gene Function
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Author : John C. Lucchesi
language : en
Publisher: Oxford University Press
Release Date : 2018-12-19
Epigenetics Nuclear Organization Gene Function written by John C. Lucchesi and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-19 with Science categories.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
Nuclear Pore Complexes In Genome Organization Function And Maintenance
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Author : Maximiliano D’Angelo
language : en
Publisher: Springer
Release Date : 2018-02-02
Nuclear Pore Complexes In Genome Organization Function And Maintenance written by Maximiliano D’Angelo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-02 with Medical categories.
The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome.
Functional Organization Of The Plant Nucleus
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Author : Iris Meier
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-16
Functional Organization Of The Plant Nucleus written by Iris Meier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-16 with Science categories.
In a presentation to the Linnean Society of London in November 1831, the Scottish botanist Robert Brown (perhaps better known for his discovery of Brownian motion) mentioned almost as an afterthought that in orchid epidermal cells, a single “circular areola” could be seen, a “nucleus of the cell as perhaps it might be termed.” Thus, the term “nucleus” (from Latin nucleus or nuculeus, “little nut” or kernel) was born for the compartment of the eukaryotic cell that contains the maj- ity of genetic information. One hundred and seventy-seven years later, we know that the nucleus is the site where genetic information is stored in the form of DNA, and where it is protected from damage, duplicated, divided, recombined, repaired, and “expressed.” For the latter, the genetic information is faithfully transcribed from DNA to RNA, then released from the nucleus into the surrounding cytoplasm. Most likely translated into polypeptide chains, the information re-enters the nucleus in the form of diverse proteins that function in the processes listed above.
Functional Organization Of The Nucleus
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Author :
language : en
Publisher: Academic Press
Release Date : 1992-02-03
Functional Organization Of The Nucleus written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-02-03 with Science categories.
Functional Organization of The Nucleus
Genome Structure And Function
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Author : C. Nicolini
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Genome Structure And Function written by C. Nicolini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Proceedings of the NATO Advanced Study Institute on Genome Structure and Function, held in Marciana Marina, Elba, Italy, 13-23 June 1996
The Molecular Biology Of Plant Cells
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Author : H. Smith
language : en
Publisher: Univ of California Press
Release Date : 1977-01-01
The Molecular Biology Of Plant Cells written by H. Smith and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977-01-01 with Science categories.
Plant cell structure and function; Gene expression and its regulation in plant cells; The manipulation of plant cells.