Epileptogenic And Excitotoxic Mechanisms
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Epileptogenic And Excitotoxic Mechanisms
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Author : G. Avanzini
language : en
Publisher: John Libbey Eurotext
Release Date : 1993
Epileptogenic And Excitotoxic Mechanisms written by G. Avanzini and has been published by John Libbey Eurotext this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
This volume is based on an advanced course on epileptogenic and excitotoxic mechanisms with emphasis on development. Information on partial and generalized epileptogenesis, derived from different experimental models, is comprehensively reviewed. Special sections are devoted to anatomical, biochemical and functional aspects of the maturing brain and to their interaction with epileptogenic agents.
Epileptogenic And Excitotoxic Mechanisms
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Author : Giuliano Avanzini
language : en
Publisher:
Release Date : 1993
Epileptogenic And Excitotoxic Mechanisms written by Giuliano Avanzini and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Neuronal Mechanisms Of Epileptogenesis
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Author : Roberto Di Maio
language : en
Publisher: Frontiers E-books
Release Date : 2015-01-13
Neuronal Mechanisms Of Epileptogenesis written by Roberto Di Maio and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-13 with Brain categories.
Several types of brain injuries are causes of acquired temporal lobe epilepsy (TLE). The seizure-free "latent period" that often follows the brain injury is of unknown mechanistic significance but is commonly considered as the "epileptogenic" period characterized by gradual pathogenic processes leading to the onset of clinically detectable epilepsy. Acute convulsive status epilepticus (SE) is often associated with an adverse developmental outcome characterized by learning disabilities related to the cumulative effects of seizures and development of TLE. The symptomatic manifestations of TLE appear only after a widespread irreversible damage of entorhinal cortex, and hippocampus, the brain area most affected by this disease. These pathological features of TLE reduce the possibility of successful therapeutic approaches, often rendering the disease refractory. The difficult clinical management of chronic TLE and the limited success rate of surgical approaches, increase the incapacitating nature of this specific epileptic disorder. Prevention of TLE with an appropriate intervention after a known inciting event (in the case of acquired epilepsy) might represent the most ambitious goal in the clinical treatment of this epileptic disorder, but has been largely unsuccessful to this point. Clinical trials aimed at prevention of chronic epilepsy have often produced negative, disappointing results. However, in most cases, these studies ultimately evaluated the downstream clinical manifestations, failing to monitor early, specific molecular epileptogenic events. Therefore, elucidation of the underlying mechanisms of epileptogenesis, and their time course(s) are essential. The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder.
The Causes Of Epilepsy
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Author : Simon Shorvon
language : en
Publisher: Cambridge University Press
Release Date : 2019-05-02
The Causes Of Epilepsy written by Simon Shorvon and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-02 with Medical categories.
Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.
Seizures And Epilepsy
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Author : Jerome Engel Jr
language : en
Publisher: Oxford University Press
Release Date : 2013-01-31
Seizures And Epilepsy written by Jerome Engel Jr and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-31 with Medical categories.
This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.
Jasper S Basic Mechanisms Of The Epilepsies
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Author : Jeffrey L. Noebels
language : en
Publisher: OUP USA
Release Date : 2012-06-29
Jasper S Basic Mechanisms Of The Epilepsies written by Jeffrey L. Noebels and has been published by OUP USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-29 with Medical categories.
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Status Epilepticus
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Author : Claude G. Wasterlain
language : en
Publisher: MIT Press
Release Date : 2006
Status Epilepticus written by Claude G. Wasterlain and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
A comprehensive review of recent advances in the most severe form of epilepsy, focusing on two areas in which progress has been most rapid: basic mechanisms and treatment. Interest in status epilepticus--the most extreme form of epilepsy, involving continuous seizures--has surged in the last 20 years. Since 1979 there have been over 4,000 publications on the subject, including more than 1,700 in the last five years. No other text provides such a comprehensive review of the recent advances in the field of status epilepticus. The book focuses on the two areas in which progress has been most rapid: basic mechanisms and treatment. There is now a greater understanding of the mechanisms and complications of status epilepticus at the molecular level, which should eventually lead to improved therapy, and treatment strategies today have a greater sense of urgency because of the realization that neuronal apoptosis and necrosis can be triggered very quickly. After an overview of history, classification, and epidemiology, the contributors consider clinical phenomenology, biological markers, pathophysiology, brain damage, epileptogenesis, therapeutic principles, pharmacology, and therapeutic management. Their contributions are equally divided between studies of basic mechanisms in animal models and clinical studies, so that the reader can turn easily from the reductionist experiment that isolates a small component of status to the complex clinical situation in which these principles can translate into therapeutic action. The goal is to provide a scientific rationale for clinical decisions while developing therapeutic attitudes that are firmly grounded in pathophysiology.
Introduction To Epilepsy
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Author : Gonzalo Alarcón
language : en
Publisher: Cambridge University Press
Release Date : 2012-04-26
Introduction To Epilepsy written by Gonzalo Alarcón and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-26 with Medical categories.
Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.
Imaging Biomarkers In Epilepsy
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Author : Andrea Bernasconi
language : en
Publisher: Cambridge University Press
Release Date : 2019-01-10
Imaging Biomarkers In Epilepsy written by Andrea Bernasconi and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-10 with Medical categories.
Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.
Inflammation And Epilepsy New Vistas
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Author : Damir Janigro
language : en
Publisher: Springer Nature
Release Date : 2021-05-18
Inflammation And Epilepsy New Vistas written by Damir Janigro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-18 with Medical categories.
This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.