Establishment Of An In Vitro Alzheimer S Disease Model System
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Establishment Of An In Vitro Alzheimer S Disease Model System
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Author : Chad Edward Branecki
language : en
Publisher:
Release Date : 1999
Establishment Of An In Vitro Alzheimer S Disease Model System written by Chad Edward Branecki and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Alzheimer's disease categories.
Development Of An In Vitro La N 2 Model System For The Study Of Alzheimer S Disease
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Author : Patricia Ann Murphy
language : en
Publisher:
Release Date : 1999
Development Of An In Vitro La N 2 Model System For The Study Of Alzheimer S Disease written by Patricia Ann Murphy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Alzheimer's disease categories.
Amyloidogenesis And The Cholinergic System In Alzheimer S Disease
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Author : Fracisca C. Bronfman
language : en
Publisher:
Release Date : 2000-10-01
Amyloidogenesis And The Cholinergic System In Alzheimer S Disease written by Fracisca C. Bronfman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-01 with Medical categories.
Murine In Vitro Model Of The Blood Brain Barrier Using A Nanofabricated Poly Hydroxy Styrene Membrane And Identification Of Therapeutic Biomarkers Of Alzheimer S Disease In Relation To Intravenous Immunoglobulin Therapy
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Author : Gilda Shayan
language : en
Publisher:
Release Date : 2010
Murine In Vitro Model Of The Blood Brain Barrier Using A Nanofabricated Poly Hydroxy Styrene Membrane And Identification Of Therapeutic Biomarkers Of Alzheimer S Disease In Relation To Intravenous Immunoglobulin Therapy written by Gilda Shayan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Currently, there are over 5.3 million people in the United States diagnosed with Alzheimer's disease, with the disease being the sixth leading cause of death in the country. Current drugs on the market for the treatment of Alzheimer's disease are lipophilic small molecules that cross the blood-brain barrier by passive diffusion and none have been clinically useful in reversing the symptoms of the disease. Immunotherapy with intravenous immunoglobulin (IVIg) is one of several treatment strategies now being studied as part of efforts to discover safe and more effective treatment paradigms for Alzheimer's disease. In 2005, Weill Cornell Medical College initiated the phase I clinical trial of IVIg for the treatment of Alzheimer's disease, and the clinical outcomes indicated improvements in the cognitive abilities of subjects beyond expectations. This dissertation will address combining proteomics and statistical approaches with novel designs for in vitro blood-brain barrier models with an attempt to understand the molecular basis for the disease-modifying effects of IVIg in Alzheimer's disease. The first part of the thesis focuses on the development of a new in vitro model of the blood-brain barrier based on a co-culture between primary mouse brain microvascular endothelial cells and primary rat astrocytes on commercially available polyester membranes and nanofabricated poly(hydroxyl styrene) membranes. This model serves as a successful platform technology for evaluating molecular transport across the blood-brain barrier. The permeability of central nervous system drugs across this in vitro model correlated well with in vivo data, with the correlation coefficient being 0.98. The second part of this thesis provides examples of proteomics approaches coupled with advanced statistical modeling that can be utilized to identify therapy induced biomarkers in the cerebrospinal fluid. Specifically, cerebrospinal fluid samples from Alzheimer's subjects who underwent IVIg immunotherapy were analyzed using gel-based proteomics and the results were analyzed using a statistical model to identify 25 therapeutically relevant biomarkers in response to IVIg. These proteins have been previously implicated in Alzheimer's disease and the changes in their concentration is consistent with previous reports regarding the expression of them in the brain of Alzheimer's subjects compared to normal individuals.
Methods Of Behavior Analysis In Neuroscience
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Author : Jerry J. Buccafusco
language : en
Publisher: CRC Press
Release Date : 2000-08-29
Methods Of Behavior Analysis In Neuroscience written by Jerry J. Buccafusco and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-29 with Medical categories.
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Magnesium In The Central Nervous System
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Author : Robert Vink
language : en
Publisher: University of Adelaide Press
Release Date : 2011
Magnesium In The Central Nervous System written by Robert Vink and has been published by University of Adelaide Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Apolipoprotein E And Alzheimer S Disease
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Author : A.D. Roses
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Apolipoprotein E And Alzheimer S Disease written by A.D. Roses and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.
Genedis 2018
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Author : Panayiotis Vlamos
language : en
Publisher: Springer Nature
Release Date : 2020-05-28
Genedis 2018 written by Panayiotis Vlamos and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-28 with Medical categories.
The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people.
Drug Discovery Approaches For The Treatment Of Neurodegenerative Disorders
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Author : Adeboye Adejare
language : en
Publisher: Academic Press
Release Date : 2016-09-20
Drug Discovery Approaches For The Treatment Of Neurodegenerative Disorders written by Adeboye Adejare and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-20 with Medical categories.
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource
Animal Models Of Dementia
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Author : Joseph T. Coyle
language : en
Publisher:
Release Date : 1987
Animal Models Of Dementia written by Joseph T. Coyle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.