Exosomes And Micrornas In Biomedical Science
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Exosomes And Micrornas In Biomedical Science
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Author : Hamed Mirzaei
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2022-04-21
Exosomes And Micrornas In Biomedical Science written by Hamed Mirzaei and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-21 with Technology & Engineering categories.
MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth of the tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.
Exosomes And Micrornas In Biomedical Science
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Author : Hamed Mirzaei
language : en
Publisher: Springer
Release Date : 2022-04-21
Exosomes And Micrornas In Biomedical Science written by Hamed Mirzaei and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-21 with Technology & Engineering categories.
MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth of the tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.
Microrna In Regenerative Medicine
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Author : Chandan K. Sen
language : en
Publisher: Academic Press
Release Date : 2023-05-08
Microrna In Regenerative Medicine written by Chandan K. Sen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-08 with Science categories.
Regulating virtually all biological processes, the genome's 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body's toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies. In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering. Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence. - Features chapter contributions from international leaders in the field, covering the spectrum from bench to bedside - Includes short, applied chapters offering focused discussion and practical examples - Incorporates multi-color text layout with more than 150 color figures to illustrate important findings
Novel Therapies For Combating Bone Diseases Through Advances In Bone Remodeling
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Author : Chao Liang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-17
Novel Therapies For Combating Bone Diseases Through Advances In Bone Remodeling written by Chao Liang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-17 with Science categories.
Multidisciplinary Research In Arts Science Commerce Volume 9
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Author : Chief Editor- Biplab Auddya, Editor- Dr. B.S. Rajitha, Dr. Anita Konwar, Dr. P. C. Gangurde, Ms. Prachee V Waray, Dr. Sameena Kausar, Vidwan Manjesh M
language : en
Publisher: The Hill Publication
Release Date : 2024-10-17
Multidisciplinary Research In Arts Science Commerce Volume 9 written by Chief Editor- Biplab Auddya, Editor- Dr. B.S. Rajitha, Dr. Anita Konwar, Dr. P. C. Gangurde, Ms. Prachee V Waray, Dr. Sameena Kausar, Vidwan Manjesh M and has been published by The Hill Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-17 with Antiques & Collectibles categories.
Role Of Exosomes In Biological Communication Systems
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Author : Faisal A. Alzahrani
language : en
Publisher: Springer Nature
Release Date : 2020-11-20
Role Of Exosomes In Biological Communication Systems written by Faisal A. Alzahrani and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-20 with Medical categories.
This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.
Exosomal Rna
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Author : Debalina Bhattacharya
language : en
Publisher: Elsevier
Release Date : 2024-03-29
Exosomal Rna written by Debalina Bhattacharya and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-29 with Science categories.
Exosomal RNA: Role in Human Diseases and Therapy provides an in-depth study of exosomes and their RNA in the context of a variety of diseases. The book explores the diagnostic and therapeutic potential of exosomal RNA as biomarkers across a range of different conditions, including cancer, type 2 diabetes, cardiovascular and renal disease, as well as bacterial infections and tissue repair. The link between exosomal RNA expression and neurodegenerative disease is also explored. The book goes on to share the significance of exosomal RNA in preserving cellular function, with special attention given to their role in the autophagy process. This book gives an overview of the isolation, characterization, and potential applications of exosomal RNA, providing researchers with an understanding of how they can be manipulated and utilized for the treatment of various diseases and conditions. This is an ideal reference for researchers in the field of molecular biology, cell biology, and related fields, as well as those involved in the development of therapeutics and personalized medicine. - Provides an introduction into exosomal RNA and their potential as predictive and diagnostic biomarkers for various conditions - Considers exosomal RNA in a variety of human disorders, including metabolic diseases, inflammatory diseases, and cancer - Discusses the role of exosomal RNA in preserving the cellular environment and its role in the autophagy process
Extracellular Vesicles As Next Generation Therapeutics
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Author : Sylwia Bobis-Wozowicz
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-02
Extracellular Vesicles As Next Generation Therapeutics written by Sylwia Bobis-Wozowicz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-02 with Science categories.
Diagnostic And Therapeutic Applications Of Exosomes In Cancer
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Author : Mansoor M. Amiji
language : en
Publisher: Academic Press
Release Date : 2018-05-09
Diagnostic And Therapeutic Applications Of Exosomes In Cancer written by Mansoor M. Amiji and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-09 with Science categories.
Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer. - Covers emerging pharmaceutical and diagnostic applications, including exosomes being tested as carriers of anticancer drugs, ongoing clinical trials, and exosomes as imaging agents for cancer diagnosis and treatment - Brings together a team of highly regarded international authors who provide a full-rounded analysis - Presents comprehensive coverage of the unique biophysical properties of exosomes - Explores current and future possibilities
Emerging Concepts Of Tumor Exosome Mediated Cell Cell Communication
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Author : Huang-Ge Zhang
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-06
Emerging Concepts Of Tumor Exosome Mediated Cell Cell Communication written by Huang-Ge Zhang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-06 with Medical categories.
In multicellular organisms, communication between cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercellular communication has recently become the subject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. They are also being studied as prognostic markers for cancer.