Fault Tolerant Digital Microfluidic Biochips

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Fault Tolerant Digital Microfluidic Biochips

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Author : Paul Pop
language : en
Publisher: Springer
Release Date : 2015-09-07

Fault Tolerant Digital Microfluidic Biochips written by Paul Pop and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-07 with Technology & Engineering categories.

This book describes for researchers in the fields of compiler technology, design and test, and electronic design automation the new area of digital microfluidic biochips (DMBs), and thus offers a new application area for their methods. The authors present a routing-based model of operation execution, along with several associated compilation approaches, which progressively relax the assumption that operations execute inside fixed rectangular modules. Since operations can experience transient faults during the execution of a bioassay, the authors show how to use both offline (design time) and online (runtime) recovery strategies. The book also presents methods for the synthesis of fault-tolerant application-specific DMB architectures. · Presents the current models used for the research on compilation and synthesis techniques of DMBs in a tutorial fashion; · Includes a set of “benchmarks”, which are presented in great detail and includes the source code of most of the techniques presented, including solutions to the basic compilation and synthesis problems; · Discusses several new research problems in detail, using numerous examples.

Compilation And Synthesis For Fault Tolerant Digital Microfluidic Biochips

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Author : Mirela Alistar
language : en
Publisher:
Release Date : 2014

Compilation And Synthesis For Fault Tolerant Digital Microfluidic Biochips written by Mirela Alistar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

Phd

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Author : Mirela Alistar
language : en
Publisher:
Release Date : 2014

Phd written by Mirela Alistar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

Digital Microfluidic Biochips

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Author : Krishnendu Chakrabarty
language : en
Publisher: CRC Press
Release Date : 2018-10-03

Digital Microfluidic Biochips written by Krishnendu Chakrabarty and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-03 with Technology & Engineering categories.

Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips. Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.

Error Tolerant Biochemical Sample Preparation With Microfluidic Lab On Chip

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Author : Sudip Poddar
language : en
Publisher: CRC Press
Release Date : 2022-07-27

Error Tolerant Biochemical Sample Preparation With Microfluidic Lab On Chip written by Sudip Poddar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Technology & Engineering categories.

Microfluidic biochips have gained prominence due to their versatile applications to biochemistry and health-care domains such as point-of-care clinical diagnosis of tropical and cardiovascular diseases, cancer, diabetes, toxicity analysis, and for the mitigation of the global HIV crisis, among others. Microfluidic Lab-on-Chips (LoCs) offer a convenient platform for emulating various fluidic operations in an automated fashion. However, because of the inherent uncertainty of fluidic operations, the outcome of biochemical experiments performed on-chip can be erroneous even if the chip is tested a priori and deemed to be defect-free. This book focuses on the issues encountered in reliable sample preparation with digital microfluidic biochips (DMFBs), particularly in an error-prone environment. It presents state-of-the-art error management techniques and underlying algorithmic challenges along with their comparative discussions. Describes a comprehensive framework for designing a robust and error-tolerant biomedical system which will help in migrating from cumbersome medical laboratory tasks to small-sized LOC-based systems Presents a comparative study on current error-tolerant strategies for robust sample preparation using DMFBs and reports on efficient algorithms for error-tolerant sample dilution using these devices Illustrates how algorithmic engineering, cyber-physical tools, and software techniques are helpful in implementing fault tolerance Covers the challenges associated with design automation for biochemical sample preparation Teaches how to implement biochemical protocols using software-controlled microfluidic biochips Interdisciplinary in its coverage, this reference is written for practitioners and researchers in biochemical, biomedical, electrical, computer, and mechanical engineering, especially those involved in LOC or bio-MEMS design.

Design And Testing Of Digital Microfluidic Biochips

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Author : Yang Zhao
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-25

Design And Testing Of Digital Microfluidic Biochips written by Yang Zhao and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-25 with Technology & Engineering categories.

This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.

Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms

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Author : Mohamed Ibrahim
language : en
Publisher: CRC Press
Release Date : 2020-05-31

Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms written by Mohamed Ibrahim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-31 with Technology & Engineering categories.

A microfluidic biochip is an engineered fluidic device that controls the flow of analytes, thereby enabling a variety of useful applications. According to recent studies, the fields that are best set to benefit from the microfluidics technology, also known as lab-on-chip technology, include forensic identification, clinical chemistry, point-of-care (PoC) diagnostics, and drug discovery. The growth in such fields has significantly amplified the impact of microfluidics technology, whose market value is forecast to grow from $4 billion in 2017 to $13.2 billion by 2023. The rapid evolution of lab-on-chip technologies opens up opportunities for new biological or chemical science areas that can be directly facilitated by sensor-based microfluidics control. For example, the digital microfluidics-based ePlex system from GenMarkDx enables automated disease diagnosis and can bring syndromic testing near patients everywhere. However, as the applications of molecular biology grow, the adoption of microfluidics in many applications has not grown at the same pace, despite the concerted effort of microfluidic systems engineers. Recent studies suggest that state-of-the-art design techniques for microfluidics have two major drawbacks that need to be addressed appropriately: (1) current lab-on-chip systems were only optimized as auxiliary components and are only suitable for sample-limited analyses; therefore, their capabilities may not cope with the requirements of contemporary molecular biology applications; (2) the integrity of these automated lab-on-chip systems and their biochemical operations are still an open question since no protection schemes were developed against adversarial contamination or result-manipulation attacks. Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms provides solutions to these challenges by introducing a new design flow based on the realistic modeling of contemporary molecular biology protocols. It also presents a microfluidic security flow that provides a high-level of confidence in the integrity of such protocols. In summary, this book creates a new research field as it bridges the technical skills gap between microfluidic systems and molecular biology protocols but it is viewed from the perspective of an electronic/systems engineer.

Digital Microfluidic Biochips

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Author : Krishnendu Chakrabarty
language : en
Publisher: CRC Press
Release Date : 2010-05-03

Digital Microfluidic Biochips written by Krishnendu Chakrabarty and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-03 with Medical categories.

Microfluidics-based biochips combine electronics with biochemistry, providing access to new application areas in a wide variety of fields. Continued technological innovations are essential to assuring the future role of these chips in functional diversification in biotech, pharmaceuticals, and other industries.Revolutionary guidance on design, opti

Exact Design Of Digital Microfluidic Biochips

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Author : Oliver Keszocze
language : en
Publisher: Springer
Release Date : 2018-06-11

Exact Design Of Digital Microfluidic Biochips written by Oliver Keszocze and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-11 with Technology & Engineering categories.

This book presents exact, that is minimal, solutions to individual steps in the design process for Digital Microfluidic Biochips (DMFBs), as well as a one-pass approach that combines all these steps in a single process. All of the approaches discussed are based on a formal model that can easily be extended to cope with further design problems. In addition to the exact methods, heuristic approaches are provided and the complexity classes of various design problems are determined. Presents exact methods to tackle a variety of design problems for Digital Microfluidic Biochips (DMFBs); Describes an holistic, one-pass approach solving different design steps all at once; Based on a formal model of DMFBs that is easily adaptable to deal with further design tasks.

Secure And Trustworthy Cyberphysical Microfluidic Biochips

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Author : Jack Tang
language : en
Publisher: Springer
Release Date : 2019-05-28

Secure And Trustworthy Cyberphysical Microfluidic Biochips written by Jack Tang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-28 with Technology & Engineering categories.

This book describes novel hardware security and microfluidic biochip design methodologies to protect against tampering attacks in cyberphysical microfluidic biochips (CPMBs). It also provides a general overview of this nascent area of research, which will prove to be a vital resource for practitioners in the field.This book shows how hardware-based countermeasures and design innovations can be a simple and effective last line of defense, demonstrating that it is no longer justifiable to ignore security and trust in the design phase of biochips.