Gaba And Glutamate
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Gaba And Glutamate
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Author : Janko Samardzic
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-03-21
Gaba And Glutamate written by Janko Samardzic and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-21 with Medical categories.
This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.
Glutamate And Gaba Receptors And Transporters
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Author : Jan Egebjerg
language : en
Publisher: CRC Press
Release Date : 2001-10-04
Glutamate And Gaba Receptors And Transporters written by Jan Egebjerg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-10-04 with Science categories.
The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover, continuous development of novel and selective drugs has revealed detailed information on the mechanism of receptor activation and regulation. However, the rapid development of different aspects of glutamate and GABA receptor research makes it increasingly difficult to establish a general view of the field. Studies of the receptors are a multi-disciplinary task employing many specialised techniques. This book conveys recent discoveries in a framework of the basic concepts in the field of glutamate and GABA receptor research. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology is suitable for postgraduate students studying ligand gated channels but also beneficial for industrial and academic research scientists in both the glutamate and GABA field. Universities offering programs in neuroscience, molecular pharmacology or medicinal chemistry will find this a valuable reference.
The Glutamate Gaba Glutamine Cycle
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Author : Arne Schousboe
language : en
Publisher: Springer
Release Date : 2016-11-25
The Glutamate Gaba Glutamine Cycle written by Arne Schousboe and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-25 with Medical categories.
Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.
Gaba And Glutamate New Developments In Neurotransmission Research
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Author :
language : en
Publisher:
Release Date : 19??
Gaba And Glutamate New Developments In Neurotransmission Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.
Magnetic Resonance Spectroscopy Of Gaba And Glutamate In Mental Health
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Author : Maria Concepcion Garcia Otaduy
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-31
Magnetic Resonance Spectroscopy Of Gaba And Glutamate In Mental Health written by Maria Concepcion Garcia Otaduy and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-31 with Science categories.
Astrocytic Neuronal Astrocytic Pathway Selection For Formation And Degradation Of Glutamate Gaba
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Author : Leif Hertz
language : en
Publisher: Frontiers E-books
Release Date : 2014-04-30
Astrocytic Neuronal Astrocytic Pathway Selection For Formation And Degradation Of Glutamate Gaba written by Leif Hertz and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-30 with Astrocytes categories.
Endocrinological research early recognized the importance of intercellular interactions and realized the importance of glutamatergic and GABAergic signaling. In turn this signalling depends on elaborate interactions between astrocytes and neurons, without which neurons would be unable to produce, reuse and metabolize transmitter glutamate and GABA. Details of these subjects are described in this Research Topic by key investigators in this field. It focuses on the intricate and extremely swift pathway producing these amino acid transmitters from glucose in brain but also discusses difficulties in determining expression of some of the necessary genes in astrocytes and related processes in pancreatic islets. However, it does not discuss how closely associated astrocytes and neurons are anatomically, enabling these interactions. This is elegantly shown in this cover image, kindly provided by Professor Andreas Reichenbach (University of Leipzig, Germany).
Gaba Receptors Transporters And Metabolism
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Author : Chikako Tanaka
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Gaba Receptors Transporters And Metabolism written by Chikako Tanaka and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Highlighting the current developments and future directions in GABA research, the ambitious aim of this topical volume is to cover GABA from the molecular mechanisms of its transmission to new targets for pharmaceutical research. Distinguished scientists at the forefront of GABA research were invited to contribute reviews on glutamate decarboxylase and autoimmunity, molecular structure and functional regulation of GABA transporters, transmitter release and GABA receptor regulation, GABA receptor subtypes and functional regulation, and GABA receptor ligands and their therapeutic application. Describing the latest advances in what has become a rapidly-evolving field, this volume will prove immensely valuable to neuroscientists, pharmacologists, biochemists, and physiologists working in the field of GABA research.
Gaba In Nervous System Function
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Author : Eugene Roberts
language : en
Publisher:
Release Date : 1976
Gaba In Nervous System Function written by Eugene Roberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Medical categories.
Gaba Outside The Cns
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Author : Sandor L. Erdö
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Gaba Outside The Cns written by Sandor L. Erdö and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
during the past few years increasing interest has been focused on the role of gamma-aminobutyric acid (GABA) outside the central nervous systems (CNS).Biochemical, pharmacological, histochemical, physiological approaches have all been employed to investigate the role of GABA in themammalian periphery. The International Symposium on Peripheral GABAergic Mechanism held in Rome, July 1990, was devoted to gather scientists from allover the world in order to summarize and sythesize their most recent results and conceptions on the significance of GABA outside the CNS. Written in a thought-provoking style, this proceedings volume is an overviewof the timely knowledge about GABA in the peripheral nervous system and in non-neuronal tissues. Chapters of the book provide many examples for the diverse functions of this amino acid in the periphery as neurotransmitter, hormone, humoral or even trophic factor from the autonomic ganglia to the endocrine stomach and pancreas, from the tubular epithelium of the kidney to the spermatozoa.
Glutamine And Glutamate Mammals
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Author : Elling Kvamme
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Glutamine And Glutamate Mammals written by Elling Kvamme and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Medical categories.
Based on the joint effort of a great many top scientists, this book covers most aspects of the metabolism and function of glutamine and glutamate in mammals.