Genetic And Epigenetic Foundations Molecular Basis And Mechanistic Pathways Of Chronic Inflammation Driven Tumorigenesis
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Genetic And Epigenetic Foundations Molecular Basis And Mechanistic Pathways Of Chronic Inflammation Driven Tumorigenesis
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Author : Jeff Radwell
language : en
Publisher: Black Mill Publishing
Release Date : 2025-01-29
Genetic And Epigenetic Foundations Molecular Basis And Mechanistic Pathways Of Chronic Inflammation Driven Tumorigenesis written by Jeff Radwell and has been published by Black Mill Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-29 with Medical categories.
Chronic inflammation is a silent yet powerful driver of cancer, altering genetic and epigenetic landscapes to promote tumor progression, immune evasion, and therapy resistance. This comprehensive volume unpacks the intricate molecular mechanisms linking inflammation and oncogenesis, from oxidative DNA damage to epigenetic modifications that rewire cellular fate. Examining key pathways such as NF-κB, STAT3, and TGF-β, this text provides a rigorous yet accessible analysis of inflammation-driven tumorigenesis. With a focus on genetic mutations, histone modifications, and therapeutic targets, it bridges fundamental research with clinical implications, offering insights into novel intervention strategies.
The Immunogenome
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Author : Jeff Radwell
language : en
Publisher:
Release Date : 2025-03-01
The Immunogenome written by Jeff Radwell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-01 with Medical categories.
Your immune system is as unique as your DNA, shaped by genetic inheritance, environmental exposures, and epigenetic modifications that influence how your body fights infections, responds to vaccines, and even determines your risk for autoimmune diseases, cancer, and chronic inflammation. But what if we could decode the genetic blueprint that governs these immune response, and even modify it? In The Immunogenome, examine how advances in immunogenomics, epigenetics, and systems biology are transforming our understanding of immune function, and why genetic polymorphisms, regulatory elements, and environmental factors contribute to differential susceptibility. This book delves into the intricate mechanisms by which transcriptional regulation, DNA methylation, histone modifications, and non-coding RNAs modulate immune gene expression inducing long-lasting epigenetic reprogramming of immune pathways. By bridging molecular immunology with precision medicine, The Immunogenome presents an encyclopedic framework for understanding how genetic and epigenetic networks govern immunological resilience and dysfunction.
Genetic And Epigenetic Foundations Molecular Basis And Mechanistic Pathways Of Chronic Inflammation Driven Tumorigenesis
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Author : Jeff Radwell
language : en
Publisher:
Release Date : 2025-01-29
Genetic And Epigenetic Foundations Molecular Basis And Mechanistic Pathways Of Chronic Inflammation Driven Tumorigenesis written by Jeff Radwell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-29 with Medical categories.
A comprehensive overview of the molecular and cellular mechanisms that link chronic inflammation to cancer. It examines how chronic inflammation promotes tumor development by driving genetic mutations, epigenetic changes, and the disruption of critical cellular pathways. Key signaling networks are explored in detail, revealing their central roles in cancer progression, immune suppression, and therapy resistance. Chronic inflammation is a silent yet powerful driver of cancer, altering genetic and epigenetic landscapes to promote tumor progression, immune evasion, and therapy resistance. This comprehensive volume unpacks the intricate molecular mechanisms linking inflammation and oncogenesis, from oxidative DNA damage to epigenetic modifications that rewire cellular fate. Examining key pathways such as NF-¿B, STAT3, and TGF-ß, this text provides a rigorous yet accessible analysis of inflammation-driven tumorigenesis. With a focus on genetic mutations, histone modifications, and therapeutic targets, it bridges fundamental research with clinical implications, offering insights into novel intervention strategies. This text discusses how reactive oxygen species, DNA damage, and epigenetic reprogramming work together to create a permissive environment for malignancy. Insights into the involvement of immune modulation and the microbiome further underscore the complexity of inflammation-driven cancers.
Pathology Volume I
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Author : Mr. Rohit Manglik
language : en
Publisher: EduGorilla Publication
Release Date : 2024-05-24
Pathology Volume I written by Mr. Rohit Manglik and has been published by EduGorilla Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-24 with Medical categories.
Covers general pathology principles including cell injury, inflammation, and neoplasia. Sets the foundation for understanding disease mechanisms.
Inflammation In Respiratory And Neurological Diseases And The Immune Interaction Of The Lung Brain Axis
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Author : Xiaohuan Xia
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-18
Inflammation In Respiratory And Neurological Diseases And The Immune Interaction Of The Lung Brain Axis written by Xiaohuan Xia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-18 with Medical categories.
Despite great advances in diagnosis and treatment that we witnessed in the last decades, over a billion people suffer from both respiratory and neurological diseases each year, which poses great threats to the public health and economic burden worldwide. In many instances, the underlying pathogenic mechanisms are still poorly understood, which significantly limits the efficacy of therapeutic methods. In this regard, lines of evidence pinpoint the important role of immunity and inflammation in both respiratory disorders (e.g., pulmonary hypertension, chronic obstructive pulmonary disease, asthma, etc.) and neurological ones (e.g., neurodegenerative diseases, stroke, depression, etc.). The accumulation of inflammatory cells and an excess of cytokines and chemokines at the inflammatory site would result from the disturbance of the body's delicate balance between immunity and tolerance. Therefore, it gives rise to chronic inflammation and autoimmunity underlying the development of both lung and neurological diseases. Furthermore, the inflammation interaction between lung and brain has been identified, suggesting the existence and importance of the lung-brain axis in the regulation of immune responses in the lung and brain that contribute to the onset and progression of both respiratory and neurological diseases. Nevertheless, inflammatory or immunity related risk factors as well novel targets and therapies against inflammation or immunity help early diagnosis and treatment of respiratory and neurological diseases. At present, the full picture of the molecular mechanisms of how immuno-inflammatory activation and the immune cells orchestrate the tissue remodeling leading to respiratory and neurological diseases remains unclear. The identification of inflammatory molecules as therapeutic targets or biomarkers are worth further scrutiny to halt the disease progression and monitor the therapeutic interventions.
Cancer And Inflammation Mechanisms
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Author : Yusuke Hiraku
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-19
Cancer And Inflammation Mechanisms written by Yusuke Hiraku and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-19 with Science categories.
A new perspective on the link between inflammation and cancer Inflammation is the human body’s normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory response is triggered repeatedly and sustained for long periods of time? Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects discusses the mechanisms by which chronic inflammation can lead to cancer, the various causative agents, and possible prevention methods. A compilation of the latest information coming out of the various fields of cancer research, this book provides a detailed look at inflammation-related carcinogenesis from the perspective of researchers at the forefront of the field. It takes an interdisciplinary approach to the topic, and provides comprehensive information about the major factors at work in inflammation, cancer, and the intersection of the two conditions. Topics include: A general overview of inflammation-related cancer The biochemistry of inflammation and its effects on DNA Molecular biology and the role of microRNA in carcinogenesis Specific causative agents including oncogenic viruses, asbestos, and nanomaterial Anti-inflammatories, nutraceuticals, and other preventative measures A deeper understanding of the mechanisms behind inflammation-related carcinogenesis can lead to better patient outcomes by improving diagnostics and prevention, as well as altering the approach to treatment. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects provides the knowledge base researchers need to push the field forward.
Inflammation And Cancer
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Author : Serguei V. Kozlov
language : en
Publisher: Humana Press
Release Date : 2011-09-17
Inflammation And Cancer written by Serguei V. Kozlov and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-17 with Medical categories.
According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 2, Molecular Analysis and Pathways is devoted to an extensive description of experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development and drug target discovery. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.
Cancer And Inflammation
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Author : Novartis Foundation
language : en
Publisher: Wiley
Release Date : 2004-03-05
Cancer And Inflammation written by Novartis Foundation and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-05 with Science categories.
Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems. Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subvert antitumour immunity by favouring development of ineffective Type 2 responses. Tumour cells may even utilize chemokine receptors in homing to lymph nodes and other organs. Thus, the cells, cytokines and chemokines found in tumours are more likely to contribute to tumour growth, progression and immunosuppression than they are to mount an effective host antitumour response. This book draws together contributions from an international group of scientists and clinicians from diverse disciplines, ranging from epidemiology to immunology, cell biology, molecular oncology, molecular medicine and pharmacology to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative and therapeutic strategies. Related Novartis Foundation symposia: 252 Generation and Effector Functions of Regulatory Lymphocytes Chair: Jean-Fran?ois Bach 254 Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function Chair: Hans-Georg Rammensee