Genetic Techniques And Circuit Analysis
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Genetic Techniques And Circuit Analysis
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Author : William Wisden
language : en
Publisher: Frontiers E-books
Release Date :
Genetic Techniques And Circuit Analysis written by William Wisden and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
How new genetic techniques are revolutionizing the study of neural circuits for both invertebrate and vertebrate systems. Understanding how specific types of neurons contribute to behaviour is an ambitious goal. For invertebrate model systems (e.g. worms, flies), neurons in the brain are often too small to be studied routinely by electrophysiological approaches. For vertebrates, large ensembles of cells have to be studied, and these cells are often distributed over considerable volumes e.g. GABAergic interneurons in neocortex. Cell type-selective manipulations may be a way forward for treating illness. Before such aims can be realized, or even appreciated as feasible, the brain circuitry in experimental animals has to be known by both establishing the connections between cell types and reversibly manipulating the activity of the cells subtype-selectively. Methods that have all appeared in just the last couple of years to tackle this include: retrograde tracing of circuitry using viruses, ligand-receptor combinations that make subtypes of neurons uniquely sensitive to a drug (e.g. zolpidem, allatostatin, serotonin ligands or ivermectin), and light-activated channels and pumps for stimulation and inhibition. This collection of methods promises much, forming the new subdisciplines of “pharmacogenetics” and “opticogenetics”. These methods are revolutionizing the study of brain circuitry for both invertebrates and vertebrate systems.
Rosenberg S Molecular And Genetic Basis Of Neurological And Psychiatric Disease Seventh Edition
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Author : Roger N. Rosenberg
language : en
Publisher: Elsevier
Release Date : 2024-10-07
Rosenberg S Molecular And Genetic Basis Of Neurological And Psychiatric Disease Seventh Edition written by Roger N. Rosenberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-07 with Medical categories.
Rosenberg's Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Seventh Edition provides a comprehensive introduction and reference to the foundations and practical aspects relevant to the majority of neurologic and psychiatric disease. This updated volume focuses on degenerative disorders, movement disorders, neuro-oncology, neurocutaneous disorders, epilepsy, white matter diseases, neuropathies and neuronopathies, muscle and neuromuscular junction disorders, stroke, psychiatric disease, and a neurologic gene map. This volume includes new chapters on Von Hippel-Lindau disease, antisocial and violent behavior and Autism. A favorite of over four generations of students, clinicians and scholars, this new edition retains and expands on the informative, concise and critical tone of the previous edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, related professionals, and for the neuroscience and neurology research community at large. - Both volumes combined provide a comprehensive coverage on the neurogenetic foundation of neurological and psychiatric disease - This volume presents detailed coverage of disease mechanisms, and management for degenerative disorders, movement disorders, and muscle and neuromuscular junction disorders. - Includes new chapters on the pharmacogenomics of Alzheimer's Disease and Epilepsy and the most recent updates in molecular genetics, focusing on pain genetics and muscular dystrophy
The World According To Zebrafish How Neural Circuits Generate Behaviour
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Author : Gonzalo G. De Polavieja
language : en
Publisher: Frontiers E-books
Release Date : 2014-11-07
The World According To Zebrafish How Neural Circuits Generate Behaviour written by Gonzalo G. De Polavieja and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-07 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.
Principles Of Neurobiology
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Author : Liqun Luo
language : en
Publisher: Garland Science
Release Date : 2015-07-14
Principles Of Neurobiology written by Liqun Luo and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-14 with Science categories.
Principles of Neurobiology presents the major concepts of neuroscience with an emphasis on how we know what we know. The text is organized around a series of key experiments to illustrate how scientific progress is made and helps upper-level undergraduate and graduate students discover the relevant primary literature. Written by a single author in
Circadian Rhythms And Biological Clocks Part B
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-02-24
Circadian Rhythms And Biological Clocks Part B written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-24 with Science categories.
Two new volumes of Methods in Enzymology continue the legacy of this premier serial with quality chapters authored by leaders in the field. Circadian Rhythms and Biological Clocks Part A and Part B is an exceptional resource for anybody interested in the general area of circadian rhythms. As key elements of timekeeping are conserved in organisms across the phylogenetic tree, and our understanding of circadian biology has benefited tremendously from work done in many species, the volume provides a wide range of assays for different biological systems. Protocols are provided to assess clock function, entrainment of the clock to stimuli such as light and food, and output rhythms of behavior and physiology. This volume also delves into the impact of circadian disruption on human health. Contributions are from leaders in the field who have made major discoveries using the methods presented here. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods in biomineralization science - Keeping with the interdisciplinary nature of the circadian rhythm field, the volume includes diverse approaches towards the study of rhythms, from assays of biochemical reactions in unicellular organisms to monitoring of behavior in humans.
Nitric Oxide
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Author : Louis J. Ignarro
language : en
Publisher: Academic Press
Release Date : 2009-11-05
Nitric Oxide written by Louis J. Ignarro and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-05 with Science categories.
Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide's role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. - Edited by Nobel Laureate Louis J. Ignarro - Up-to-date therapeutic implications of nitric oxide research - Authored by world experts on nitric oxide - Detailed research of the biochemistry and synthesis of nitric oxide
Motor Neurobiology Of The Spinal Cord
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Author : Timothy C. Cope
language : en
Publisher: CRC Press
Release Date : 2001-06-26
Motor Neurobiology Of The Spinal Cord written by Timothy C. Cope and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-06-26 with Medical categories.
Motor Neurobiology of the Spinal Cord provides a comprehensive description of the experimental tools available for investigating the neuronal properties that allow populations of spinal cord neurons to control muscles responsible for limb movements and posture control. By integrating data from many new approaches, this text demonstrates how spinal cord circuits operate under a variety conditions and explores the new and exciting developments that are being made in motor neurobiology of the spinal cord. It also elucidates concepts and principles relevant to function and structure throughout the nervous system and presents information about changes induced by injury and disease.
Neural Circuits Japan
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Author : Yasuo Kawaguchi
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-05
Neural Circuits Japan written by Yasuo Kawaguchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-05 with Neural circuitry categories.
This Frontiers Research Topic on ‘Neural Circuits: Japan’ explores the diversity of neural circuit research occurring across Japan by innovative researchers using cutting-edge approaches. This issue has brought together papers revealing the development, structure, and physiology of neuronal circuits involved in sensory perception, sleep and wakefulness, behavioral selection, and motor command generation in a range of species from the nematode to the primate. Like the USA and Europe, Japan is now making a strong effort to elucidate neural circuit function in diverse organisms by taking advantages of optogenetics and innovative approaches for gene manipulation, traditional physiological and anatomical approaches, and neural pathway-selective inactivation techniques that have recently been developed in Japan.
Genetic Dissection Of Neural Circuits And Behavior
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Author :
language : en
Publisher: Academic Press
Release Date : 2009-07-14
Genetic Dissection Of Neural Circuits And Behavior written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-14 with Science categories.
Genes interact with the environment, experience, and biology of the brain to shape an animal's behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. - Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models - Includes methods for testing with ethical, legal, and social implications - Critically analyzes future prospects
Techniques And Environments For Big Data Analysis
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Author : B. S.P. Mishra
language : en
Publisher: Springer
Release Date : 2016-02-05
Techniques And Environments For Big Data Analysis written by B. S.P. Mishra and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-05 with Technology & Engineering categories.
This volume is aiming at a wide range of readers and researchers in the area of Big Data by presenting the recent advances in the fields of Big Data Analysis, as well as the techniques and tools used to analyze it. The book includes 10 distinct chapters providing a concise introduction to Big Data Analysis and recent Techniques and Environments for Big Data Analysis. It gives insight into how the expensive fitness evaluation of evolutionary learning can play a vital role in big data analysis by adopting Parallel, Grid, and Cloud computing environments.