Genetics Of Alzheimer S Disease
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Genetic Variants In Alzheimer S Disease
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Author : Kevin Morgan
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-22
Genetic Variants In Alzheimer S Disease written by Kevin Morgan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-22 with Medical categories.
Alzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades. This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s. These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure. The aim of this book is to put all of the recent genetic data on these new genes into context. Different genetic variants will be discussed, as well as biomarkers and future possibilities.
Genetics And Alzheimer S Disease
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Author : Pierre M. Sinet
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-07
Genetics And Alzheimer S Disease written by Pierre M. Sinet and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
This volume contains the proceedings of the meeting Genetics and Alzheimer's Disease held in Paris, on March 25,1988, by the Fondation Ipsen pour la Recherche Therapeuti que. This meeting was the second of the series of Colloques Medecine et Recherche devoted to Alzheimer's disease. The first one was held in Angers (France) on September 14, 1987; the proceedings of this meeting have already been published and are entitled Immunology and Alzheimer's Disease (1988, edited by A Pouplard-Barthelaix, J Emile, and Y Christen). The third Colloque Medecine et Recherche, organized in Montpellier on Sep tember 19, 1988, dealt with neuronal grafting; the proceedings of this last meeting will be published in early 1989 (Neuronal Grafting and Alzheimer's Disease: Future Perspectives, edited by F Gage, A Privat and Y Christen). In each case, the Fondation Ipsen deliberately focuses attention on the most up-to-date themes, and sometimes the most controversial ones, from medical and scientific research. The genetic aspects of Alzheimer's Disease (AD) stands at the very forefront of research carried out in the last 2 years. It complements research using the formal approach, which has become possible thanks to the study of extended kindreds by J-F Foncin and other scientists. The recent work on molecular and genetics biology has followed two main pathways: 1. The study of the gene(s) responsible for the familial form(s), which can be considered the AD gene(s).
Genetics Of Alzheimer S Disease
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Author : Laura Ibanez
language : en
Publisher: Mdpi AG
Release Date : 2022-01-27
Genetics Of Alzheimer S Disease written by Laura Ibanez and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Science categories.
This special issue on the genetics of Alzheimer's disease was edited by Drs. Laura Ibanez and Justin Miller in 2021. It contains 10 original articles and reviews that help readers understand specific genetic contributions to Alzheimer's disease and how genetics will play a role in future Alzheimer's disease research.
Alzheimer S Disease
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Author : Evelyn B. Kelly
language : en
Publisher: Infobase Publishing
Release Date : 2008
Alzheimer S Disease written by Evelyn B. Kelly and has been published by Infobase Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Alzheimer's disease categories.
First documented at the turn of the century by German neurologist Alois Alzheimer, Alzheimer's disease is the most common dementia in older adults, robbing them of their minds and dignity. With the aging of the world's population, incidences of this degenerative brain disease are set to dramatically increase by 2010. However, there may be hope. Research at the genetic level is uncovering secrets of what makes up the disease and how it works. Presenting a history of Alzheimer's disease, this title looks at the human genome and explores how the pieces of the Alzheimer's puzzle are beginning to fit together. Alzheimer's Disease is an adventure into the exciting world of the search for a cure.
Alzheimer S Disease
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Author : Sangram S. Sisodia
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-16
Alzheimer S Disease written by Sangram S. Sisodia and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-16 with Medical categories.
This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.
Molecular Biology Of Alzheimer S Disease
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Author : Christian Haass
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Molecular Biology Of Alzheimer S Disease written by Christian Haass and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Science categories.
Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.
Decoding Darkness
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Author : Rudolph E Tanzi
language : en
Publisher: Basic Books
Release Date : 2008-01-07
Decoding Darkness written by Rudolph E Tanzi and has been published by Basic Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-07 with Science categories.
Working from the intriguing hypothesis that Alzheimer's dementia is the result of a renegade protein-beta amyloid-Tanzi and others set out to find the gene responsible for its production. Decoding Darkness takes us deep into the minds and far-flung labs of many a prominent researcher, offering an intimate view of the high stakes of molecular genetics, the revolution that propels it, the obstacles that threaten to derail it, and the families whose lives are so dependent upon it. Tanzi and Parson ultimately reveal that Alzheimer's, like heart disease, may be effectively treated-even prevented.
Genetics Of Alzheimer S Disease
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Author : Laura Ibanez
language : en
Publisher:
Release Date : 2022
Genetics Of Alzheimer S Disease written by Laura Ibanez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
This special issue on the genetics of Alzheimer's disease was edited by Drs. Laura Ibanez and Justin Miller in 2021. It contains 10 original articles and reviews that help readers understand specific genetic contributions to Alzheimer's disease and how genetics will play a role in future Alzheimer's disease research.
Genetic Testing For Alzheimer Disease
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Author : Stephen Garrard Post
language : en
Publisher:
Release Date : 1998
Genetic Testing For Alzheimer Disease written by Stephen Garrard Post and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Family & Relationships categories.
The genetics of Alzheimer disease has been a point of intense concern and immense informational confusion for families in which a loved one is diagnosed with dementia. In recent years, however, scientists have begun to uncover the genetic bases for some forms of Alzheimer disease. Once a chromosomal defect is identified, it becomes possible to devise a test for its presence. The far-reaching implications of such tests are the focus of the present volume. In Genetic Testing for Alzheimer Disease, Stephen G. Post and Peter J. Whitehouse bring together experts from the fields of ethics, genetics, policy, neurology, philosophy, and anthropology to examine the ethical and social aspects of genetic testing for Alzheimer disease. The authors begin by focusing on current genetic findings and their clinical applicability. They then address ethical issues in genetic testing and genetic counseling for Alzheimer disease. They examine social issues such as confidentiality, discrimination, and fairness in health care. Finally, they discuss ways to educate professionals and laypeople regarding these issues. Contributors: Robert H. Binstock, Ph.D.?Thomas D. Bird, M.D. ? Robert Mullan Cook-Deegan, M.D.? Leonard Fleck, Ph.D. ? Atwood D. Gaines, Ph.D, M.P.H. ? Eric T. Juengst, Ph.D. ? Harry Karlinsky, M.D. ? Steven Miles, M.D. ? Thomas H. Murray, Ph.D. ? Stephen G. Post, Ph.D. ? Kimberly A. Quaid, Ph.D. ? Allen D. Roses, M.D. ? Greg A. Sachs, M.D. ? Peter H. St. George-Hyslop, M.D. ? Bonnie Steinbock, Ph.D. ? Arthur B. Zinn, M.D., Ph.D.
Genes Environment And Alzheimer S Disease
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Author : Orly Lazarov
language : en
Publisher: Academic Press
Release Date : 2016-02-25
Genes Environment And Alzheimer S Disease written by Orly Lazarov and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-25 with Psychology categories.
Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists