Genomic Colocalization And Enrichment Analyses

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Genomic Colocalization And Enrichment Analyses

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Author : Geir Kjetil Sandve
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-05

Genomic Colocalization And Enrichment Analyses written by Geir Kjetil Sandve and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-05 with Science categories.

Handbook Of Statistical Genomics

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Author : David J. Balding
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-02

Handbook Of Statistical Genomics written by David J. Balding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-02 with Science categories.

A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.

Practical Guide To Life Science Databases

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Author : Imad Abugessaisa
language : en
Publisher: Springer Nature
Release Date : 2022-01-06

Practical Guide To Life Science Databases written by Imad Abugessaisa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-06 with Science categories.

This book provides the latest information of life science databases that center in the life science research and drive the development of the field. It introduces the fundamental principles, rationales and methodologies of creating and updating life science databases. The book brings together expertise and renowned researchers in the field of life science databases and brings their experience and tools at the fingertips of the researcher. The book takes bottom-up approach to explain the structure, content and the usability of life science database. Detailed explanation of the content, structure, query and data retrieval are discussed to provide practical use of life science database and to enable the reader to use database and provided tools in practice. The readers will learn the necessary knowledge about the untapped opportunities available in life science databases and how it could be used so as to advance basic research and applied research findings and transforming them to the benefit of human life. Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Advances In Virus Research

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Author :
language : en
Publisher: Academic Press
Release Date : 2016-03-17

Advances In Virus Research written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-17 with Science categories.

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology. - Contain contributions from leading authorities - Informs and updates on all the latest developments in the field of virology

Genetic And Epigenetic Control On Immune Responses Regulating Molecules In Cancer Development Progression And Treatment

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Author : Katherine Chiappinelli
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-16

Genetic And Epigenetic Control On Immune Responses Regulating Molecules In Cancer Development Progression And Treatment written by Katherine Chiappinelli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-16 with Medical categories.

In line with recent evidence, the development of cancer has been described as uncontrolled cell growth that results from gradual accumulation of genetic and epigenetic alterations, involving aberrations in oncogenes, tumor suppressor genes, and defects in genes engaged in DNA repair. As a result, cancer cells acquire a neoplastic phenotype and tumor-associated antigens (TAAs) are presented on their surface. These target structures should be recognized by cells of the immune system. However, a sequence of events at the genetic and epigenetic level disturb immune cells, and in consequence, make them unable to eliminate cancer cells. Both innate and adaptive immunity are mobilized against cancer cells. In response to the appearance of cells with malignant transformation, NK cells release perforin and granzyme, causing direct cytolysis of the target cells. They can also secrete pro-inflammatory cytokines and in that way enhance the anticancer response. The activity of NK cells is regulated by a variety of activating and inhibitory receptors including NKG2D, KIR, CD94 -NKG2 heterodimers and natural cytotoxicity receptors, TNF family ligands, as well as co-stimulatory receptors, which recognize related molecules on target cells. A fundamental trigger of the anticancer immune response is the recognition of TAAs by T cells, via the major histocompatibility complex (MHC), which should be followed by signals from co-stimulatory molecules. Full activation of T lymphocytes requires a third signal provided by the presence of cytokines, and this leads to cell proliferation, differentiation, and secretion of chemokines and cytokines. The effect is to drive the clonal expansion of the T cells directed against TAAs and to recruit other immune effector cells in order to enhance immune defense.

Vitamin D From Pathophysiology To Clinical Impact Volume Ii

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Author : Luigi Di Filippo
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-20

Vitamin D From Pathophysiology To Clinical Impact Volume Ii written by Luigi Di Filippo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-20 with Medical categories.

Building on the success of our previous volume ''Vitamin D: From Pathophysiology to Clinical Impact'', we are pleased to launch Volume II of this Research Topic. Besides the well-known positive effects on skeletal homeostasis and bone metabolism, the growing evidence highlights the importance of vitamin D also in other many extra-skeletal conditions. In both adult and pediatric populations, conditions from inflammation and infectious diseases, obesity, and diabetes, to neurological disorders, gastrointestinal conditions, neurological disorders, cardiovascular health, and malignancies can be exerted through a number of mechanisms between vitamin D and its widely expressed receptor. This fact contributes to the increasing attention towards 25(OH)D measurement in laboratory medicine in both healthy and non-healthy general populations. Moreover, available dosing recommendations for vitamin D supplementation may considerably vary in the literature depending on the clinical setting and specific cohort evaluated. Indeed, currently, there are no specific guidelines and no clear consensus on goals for optimal vitamin D status and supplementation in most extra-skeletal conditions.

Advances In Genome Assembly For Fisheries And Aquaculture

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Author : Liang Guo
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-28

Advances In Genome Assembly For Fisheries And Aquaculture written by Liang Guo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-28 with Science categories.

Guide To Yeast Genetics Functional Genomics Proteomics And Other Systems Analysis

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Author :
language : en
Publisher: Academic Press
Release Date : 2010-02-27

Guide To Yeast Genetics Functional Genomics Proteomics And Other Systems Analysis written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-27 with Science categories.

This fully updated edition of the bestselling three-part Methods in Enzymology series, Guide to Yeast Genetics and Molecular Cell Biology is specifically designed to meet the needs of graduate students, postdoctoral students, and researchers by providing all the up-to-date methods necessary to study genes in yeast. Procedures are included that enable newcomers to set up a yeast laboratory and to master basic manipulations. This volume serves as an essential reference for any beginning or experienced researcher in the field. - Provides up-to-date methods necessary to study genes in yeast - Includes proceedures that enable newcomers to set up a yeast laboratory and to master basic manipulations - Serves as an essential reference for any beginning or experienced researcher in the field

Computational Systems Biology Of Pathogen Host Interactions

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Author : Saliha Durmuş
language : en
Publisher: Frontiers Media SA
Release Date : 2016-05-30

Computational Systems Biology Of Pathogen Host Interactions written by Saliha Durmuş and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-30 with Microbiology categories.

A thorough understanding of pathogenic microorganisms and their interactions with host organisms is crucial to prevent infectious threats due to the fact that Pathogen-Host Interactions (PHIs) have critical roles in initiating and sustaining infections. Therefore, the analysis of infection mechanisms through PHIs is indispensable to identify diagnostic biomarkers and next-generation drug targets and then to develop strategic novel solutions against drug-resistance and for personalized therapy. Traditional approaches are limited in capturing mechanisms of infection since they investigate hosts or pathogens individually. On the other hand, the systems biology approach focuses on the whole PHI system, and is more promising in capturing infection mechanisms. Here, we bring together studies on the below listed sections to present the current picture of the research on Computational Systems Biology of Pathogen-Host Interactions: - Computational Inference of PHI Networks using Omics Data - Computational Prediction of PHIs - Text Mining of PHI Data from the Literature - Mathematical Modeling and Bioinformatic Analysis of PHIs Computational Inference of PHI Networks using Omics Data Gene regulatory, metabolic and protein-protein networks of PHI systems are crucial for a thorough understanding of infection mechanisms. Great advances in molecular biology and biotechnology have allowed the production of related omics data experimentally. Many computational methods are emerging to infer molecular interaction networks of PHI systems from the corresponding omics data. Computational Prediction of PHIs Due to the lack of experimentally-found PHI data, many computational methods have been developed for the prediction of pathogen-host protein-protein interactions. Despite being emerging, currently available experimental PHI data are far from complete for a systems view of infection mechanisms through PHIs. Therefore, computational methods are the main tools to predict new PHIs. To this end, the development of new computational methods is of great interest. Text Mining of PHI Data from Literature Despite the recent development of many PHI-specific databases, most data relevant to PHIs are still buried in the biomedical literature, which demands for the use of text mining techniques to unravel PHIs hidden in the literature. Only some rare efforts have been performed to achieve this aim. Therefore, the development of novel text mining methods specific for PHI data retrieval is of key importance for efficient use of the available literature. Mathematical Modeling and Bioinformatic Analysis of PHIs After the reconstruction of PHI networks experimentally and/or computationally, their mathematical modeling and detailed computational analysis is required using bioinformatics tools to get insights on infection mechanisms. Bioinformatics methods are increasingly applied to analyze the increasing amount of experimentally-found and computationally-predicted PHI data.

Advances In Genomic And Genetic Tools And Their Applications For Understanding Embryonic Development And Human Diseases

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Author : Muhammad Abu-Elmagd
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-02

Advances In Genomic And Genetic Tools And Their Applications For Understanding Embryonic Development And Human Diseases written by Muhammad Abu-Elmagd and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-02 with Science categories.